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Fatty acid elongases in mammals: Their regulation and roles in metabolism
Progress in Lipid Research, 2006A significant amount of the fatty acids synthesized by the cytosolic enzyme complex fatty acid synthase (FAS) or taken up by the diet are further elongated into very long chain fatty acids (VLCFA) in a four-step reaction cycle by membrane-bound enzymes predominantly located in the endoplasmic reticulum.
Anders Jacobsson
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Identification and characterization of two fatty acid elongases in Lipomyces starkeyi
Applied Microbiology and Biotechnology, 2020The oleaginous yeast Lipomyces starkeyi is a potential cost-effective source for the production of microbial lipids. Fatty acid elongases have vital roles in the syntheses of long-chain fatty acids. In this study, two genes encoding fatty acid elongases of L. starkeyi, LsELO1, and LsELO2 were identified and characterized.
Tomohiko Matsuzawa +2 more
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3D Structure Modeling of a Transmembrane Protein, Fatty Acid Elongase
2010Fatty acid elongase is an enzyme responsible for fatty acid chain elongation, a key step in synthesis of long chain fatty acids, including polyunsaturated fatty acids (PUFAs). Currently, the increasing demand has raised the interest in obtaining these PUFAs from alternative sources, e.g. filamentous fungi that are more economical and sustainable.
Sansai Chumningan +4 more
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The fatty acid elongase gene family in the brown planthopper, Nilaparvata lugens
Insect Biochemistry and Molecular Biology, 2019The cuticular hydrocarbon (CHC) biosynthetic pathways branches off from the synthesis of fatty acids. Fatty acid elongases (ELOs) are enzymes catalyzing the synthesis of long-chain fatty acids and thereby contribute to the diversification of CHCs. Based on bioinformatics analyses we identified 20 ELO genes in the brown planthopper, Nilaparvata lugens ...
Dan-Ting, Li +4 more
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Characterization of fatty acid elongase enzymes from germinating pea seeds
Phytochemistry, 1998In vitro biosynthesis of radioactive arachidate and behenate was observed when microsomal fractions of germinating pea seeds were incubated with exogenous stearoyl-CoA (18:0-CoA) or arachidoyl-CA (20:0-CoA) in the presence of NADPH, [2-14C]malonyl-CoA and ATP.
P B, Barrett, J L, Harwood
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A fatty acid elongase ELO with novel activity from Dictyostelium discoideum
Biochemical and Biophysical Research Communications, 2008Fatty acid elongation was examined in the cellular slime mold, Dictyostelium discoideum. Profiling of the total fatty acid content of D. discoideum indicated that fatty acid elongation is active. Orthologs of the fatty acid elongase ELO family were identified in the D.
Brenda J, Blacklock +2 more
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Regulation of hepatic fatty acid elongase 5 by LXRα–SREBP-1c
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009Dietary essential fatty acids linoleic acid and alpha-linolenic acid are converted to arachidonic-, eicosapentaenoic-, and docosahexaenoic acid under tight regulation by nutritional status and hormones. Hepatic fatty acid elongase 5 (Elovl5) elongates C18-20 polyunsaturated fatty acids (PUFAs) and is important for biosynthesis of C20-22 PUFAs.
Yan, Qin +3 more
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RT-PCR OF FATTY ACID ELONGASES
Biochemical Society Transactions, 1997A P, Kells, P V, Maynard
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Harnessing transcription factor Mga2 and fatty acid elongases to overproduce palmitoleic acid in
Biochemical Engineering Journal, 2022Kaili Nie, Jie Pang
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