Results 11 to 20 of about 6,140 (133)
Abundant intracellular IgG in enterocytes and endoderm lacking FcRn. [PDF]
PLoS ONE, 2013 FcRn, a non-classical MHCI molecule, transports IgG from mother to young and regulates the rate of IgG degradation throughout life. Brambell proposed a mechanism that unified these two functions, saying that IgG was pinocytosed nonspecifically by the ...
Sudhasri Mohanty +5 more
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Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn. [PDF]
PLoS ONE, 2012 The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation.
Ana Paula Catunda Lemos +9 more
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CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1578-1591, December 2022., 2022 Abstract Lecanemab is a humanized immunoglobulin G1 monoclonal antibody that selectively binds to soluble Aβ aggregate species, while demonstrating low affinity for Aβ monomer. This article describes the population pharmacokinetic (PK) and PK/pharmacodynamic (PD) analyses for amyloid plaques, as measured using positron emission tomography (PET), and ...
Seiichi Hayato +8 more
wiley +1 more source
Cell surface dynamics and cellular distribution of endogenous FcRn. [PDF]
PLoS ONE, 2017 A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH.
Lena D'Hooghe +3 more
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mAbs, 2023 A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller +6 more
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European Journal of Neurology, Volume 30, Issue 1, Page 266-282, January 2023., 2023 Myasthenia gravis is recognized as an immunoglobulin G autoantibody‐mediated disease, but the relationship between autoantibody levels and disease activity is unclear. We conducted a systematic literature review to evaluate this landscape, which yielded 10 studies mainly describing a positive, significant correlation.
Andreas Meisel +13 more
wiley +1 more source
THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9
Вопросы вирусологии, 2019 The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells ...
P. S. Usoltseva +4 more
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FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues
Biomolecules, 2018 Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss Webster mice, and in select human tissues. Additionally, FcRn turnover was evaluated
Tommy Li, Joseph P. Balthasar
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mAbs, 2020 The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun +3 more
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Revista Brasileira de Prescrição e Fisiologia do Exercício, 2023 Várias intervenções têm sido propostas com a finalidade de atenuar os prejuízos motores decorrentes do Acidente Vascular Encefálico (AVE), incluindo os exercícios resistidos, entretanto, é incerto qual tipo de contração priorizar para esta população.
Liliane Araújo Guimarães +3 more
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