Results 11 to 20 of about 10,163 (201)

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

JCI Insight
The homeostasis of IgG is maintained by the neonatal Fc receptor, FcRn. Consequently, antagonism of FcRn to reduce endogenous IgG levels is an emerging strategy for treating antibody-mediated autoimmune disorders using either FcRn-specific antibodies or ...
Guanglong Ma, Andrew R. Crowley, Liesbeth Heyndrickx, Ilse Rogiers, Eef Parthoens, Jolien Van Santbergen, Raimund J. Ober, Vladimir Bobkov, Hans de Haard, Peter Ulrichts, Erik Hofman, Els Louagie, Bianca Balbino, E. Sally Ward   +13 more
doaj   +5 more sources

Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method

mAbs, 2023
A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller, Carolin Tasser, Michael Tesar, Ivica Fucek, Ute Schniegler-Mattox, Joachim Koch, Kristina Ellwanger   +6 more
doaj   +4 more sources

The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
M. Pyzik, Kine M. K. Sand, J. Hubbard, J. Andersen, I. Sandlie, R. Blumberg   +5 more
semanticscholar   +6 more sources

IgG Fab Glycans Hinder FcRn-Mediated Placental Transport.

The Journal of Immunology, 2023
Abs can be glycosylated in both their Fc and Fab regions with marked effects on Ab function and binding. High levels of IgG Fab glycosylation are associated with malignant and autoimmune conditions, exemplified by rheumatoid arthritis and highly Fab ...
M. Volkov, Maximilian Brinkhaus, K. V. van Schie, A. Bondt, T. Kissel, Elvera J. van der Kooi, A. Bentlage, C. Koeleman, S. D. de Taeye, N. Derksen, R. Dolhain, Ute Braig-Scherer, T. Huizinga, M. Wuhrer, R. Toes, G. Vidarsson, D. van der Woude   +16 more
semanticscholar   +7 more sources

Roles of FcRn in Antigen-Presenting Cells during Autoimmunity and a Clinical Evaluation of Efgartigimod as an FcRn Blocker

Pathogens, 2023
The immune system is a complex network of multiple cells, tissues, and organs that protects the body against foreign pathogenic invaders. However, the immune system may mistakenly attack healthy cells and tissues due to the cross-reactivity of anti ...
Yihan Zhou, Shisong Jiang
semanticscholar   +4 more sources

Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

Journal of Biological Engineering
Background Optimizing the IgG Fc domain for neonatal Fc receptor (FcRn) binding is crucial for enhancing antibody pharmacokinetics. The prolonged serum half-life of IgG antibody is governed by its pH-dependent interaction with FcRn, enabling efficient ...
Sanghwan Ko, Migyeong Jo, Munsu Kyung, Wonju Lee, Woo Hyung Ko, Jung-Hyun Na, Youn Seo Chun, Byoung Joon Ko, Sang Taek Jung   +8 more
doaj   +2 more sources

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles

Cells
Research into the neonatal Fc receptor (FcRn) has increased dramatically ever since Simister and Mostov first purified a rat version of the receptor.
George Haddad, Judith Blaine
doaj   +3 more sources

Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties

mAbs
Nipocalimab is a human immunoglobulin G (IgG)1 monoclonal antibody that binds to the neonatal Fc receptor (FcRn) with high specificity and high affinity at both neutral (extracellular) and acidic (intracellular) pH, resulting in the reduction of ...
Nilufer P. Seth, Rui Xu, Matthew DuPrie, Amit Choudhury, Samuel Sihapong, Steven Tyler, James Meador, William Avery, Edward Cochran, Thomas Daly, Julia Brown, Laura Rutitzky, Lynn Markowitz, Sujatha Kumar, Traymon Beavers, Sayak Bhattacharya, Hsin Chen, Viraj Parge, Karen Price, Yang Wang, Siddharth Sukumaran, Yvonne Pao, Katie Abouzahr, Fiona Elwood, Jay Duffner, Sucharita Roy, Pushpa Narayanaswami, Jonathan J. Hubbard, Leona E. Ling   +28 more
doaj   +2 more sources

Human IgE does not bind to human FcRn [PDF]

Scientific Reports, 2022
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens.
Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson   +6 more
doaj   +3 more sources

FcRN receptor antagonists in the management of myasthenia gravis

Frontiers in Neurology, 2023
Myasthenia gravis (MG) is an autoimmune disorder characterized by autoantibodies specifically directed against proteins located within the postsynaptic membrane of the neuromuscular junction.
Vinaya Bhandari, Vera Bril
doaj   +2 more sources