Results 11 to 20 of about 14,752 (202)

Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies [PDF]

Scientific Reports
IgG-based therapeutic antibodies are increasingly adopted for diverse human diseases, such as cancer and autoimmune disorders displaying remarkable therapeutic performance.
SuBin Lee, Munsu Kyung, Miyeon Park, Sunha Park, JaeHoon Lee, Suyeon Kim, Seunghyeon Lee, Migyeong Jo, Sang Taek Jung, Han-Woong Lee   +9 more
doaj   +2 more sources

The FcRn from gene to protein and function: comparison between species. [PDF]

Front Immunol
Ortiz-Alegría LB, Xicoténcatl-García L, Cañedo-Solares I, Rico-Torres CP, Gómez-Chávez F.   +4 more
europepmc   +3 more sources

Pharmacovigilance analysis of FcRn antagonists in the treatment of myasthenia gravis: A disproportionality analysis based on the FAERS database. [PDF]

Hum Vaccin Immunother
Liu B, Zhang W, Chen Y, Han A, Chen D.
europepmc   +2 more sources

FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma [PDF]

Nature Communications
Glioblastoma remains a challenging indication for immunotherapy: the blood-brain barrier hampers accessibility for systemic treatments and the immunosuppressive microenvironment impedes immune attack.
Michal Beffinger, Linda Schellhammer, Betül Taskoparan, Sereina Deplazes, Ulisse Salazar, Nazanin Tatari, Frauke Seehusen, Leopold von Balthazar, Carl Philipp Zinner, Sabine Spath, Tala Shekarian, Marie-Françoise Ritz, Marta McDaid, Pascal Egloff, Iwan Zimmermann, Hideho Okada, E. Sally Ward, Jack Rohrer, Markus A. Seeger, Thorsten Buch, Gregor Hutter, Johannes vom Berg   +21 more
doaj   +2 more sources

Megalin Orchestrates FcRn Endocytosis and Trafficking

Cells, 2022
The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is the
Eileen Dahlke, Yaman Anan, Lea Maximiliane Klie, Ariane Elisabeth Hartkopf, Franziska Theilig   +4 more
doaj   +1 more source

The neonatal Fc receptor expression during macrophage differentiation is related to autophagy

Frontiers in Immunology, 2022
The neonatal Fc receptor (FcRn) plays a central role in recycling and biodistributing immunoglobulin G. FcRn is also involved in many physiological immune functions as well as pathological immune responses in cancer or autoimmune diseases.
Juliette Lamamy, Anthony Larue, Julie Mariot, Christine Dhommée, Marie-Véronique Demattei, Yves Delneste, Yves Delneste, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart   +8 more
doaj   +1 more source

Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells

Frontiers in Microbiology, 2020
Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered upon ...
Shaoju Qian, Zitong Gao, Rui Cao, Kang Yang, Yijie Cui, Shaowen Li, Shaowen Li, Shaowen Li, Xianrong Meng, Xianrong Meng, Xianrong Meng, Qigai He, Qigai He, Qigai He, Zili Li, Zili Li, Zili Li   +16 more
doaj   +1 more source

Cell surface dynamics and cellular distribution of endogenous FcRn. [PDF]

PLoS ONE, 2017
A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH.
Lena D'Hooghe, Andrew D Chalmers, Sam Heywood, Paul Whitley   +3 more
doaj   +1 more source

Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine [PDF]

, 2012
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin (IgG) across epithelia to confer passive immunity to mammalian young. In newborn rodents, FcRn transcytoses IgG from ingested milk across the intestinal epithelium for release into the ...
Bjorkman, Pamela J., Huey-Tubman, Kathryn E., Ladinsky, Mark S.   +2 more
core   +2 more sources

THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9

Вопросы вирусологии, 2019
The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells ...
P. S. Usoltseva, A. V. Alimov, A. V. Rezaykin, A. G. Sergeev, A. V. Novoselov   +4 more
doaj   +1 more source