Results 111 to 120 of about 2,914 (186)

Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis

Scientific Reports
This study delved into the role of the PI3K/AKT signaling pathway and cuproptosis in steroid-induced osteonecrosis of the femoral head (SIONFH), assessing the therapeutic potential of the PI3K agonist 740Y-P.
Shihua Gao, Haoran Zhu, Hongxing Chen, Hongduo Lu, Moshan Wen, Yinuo Fan, Deqiang Yang, Hu Li   +7 more
doaj   +1 more source

Oxaliplatin suppresses gastric cancer by inducing cuproptosis

陆军军医大学学报
Objective To investigate the capacity of oxaliplatin (OXA) in inducing cuproptosis in treatment of gastric cancer and explore the underlying mechanisms.
RAO Hang, YANG Hong
doaj   +1 more source

Engineered RAP-anchored copper-escorting liposomes for FDX1-targeted cuproptosis in glioblastoma therapy‌

Theranostics
Rationale: Glioblastoma multiforme (GBM), the most aggressive primary brain malignancy, presents considerable therapeutic challenges due to intrinsic treatment resistance and dismal clinical outcomes. Capitalizing on emerging insights into cuproptosis-mediated oncotherapy, we have developed a receptor-associated protein (RAP)-modified liposomal ...
Liu, Meng-Meng, Zhao, Ling-Xiao, Gong, Zhi-Qiang, He, Yi-Jiang, Jiang, Xue, Luo, Wei, Yu, Xin, Wang, Zhan-You   +7 more
openaire   +3 more sources

The Role of Cuproptosis in Hyperoxia-Induced Lung Injury and Its Potential for Treatment

Journal of Inflammation Research
Kaihua Yu,1,* Yunfei Gu,2,* Ying Yao,1 Jianchun Li,3 Suheng Chen,1 Hong Guo,4 Yulan Li,5 Jian Liu1,6 1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Anesthesiology Department, Gansu ...
Yu K, Gu Y, Yao Y, Li J, Chen S, Guo H, Li Y, Liu J   +7 more
doaj  

Client distribution between Chlamydomonas FDX1 and FDX2 in carbon, nitrogen and sulfur assimilation

ABSTRACT Plant-type ferredoxins (Fd) comprise small, soluble protein families that distribute electrons from photosystem I to various client proteins within the chloroplast stroma. In Chlamydomonas reinhardtii , the major, constitutively expressed FDX1/PetF supports Fd-NADP
Stefan Schmollinger, George Kusi-Appiah, David Villegas, Sarah Stainbrook, Thomas V. O’Halloran, Daniela Strenkert   +5 more
openaire   +3 more sources

ZDHHC13 prevents cuproptosis and enhances radioresistance in nasopharyngeal carcinoma cells by modulating FDX1 protein palmitoylation

European Journal of Medical Research
Background Radioresistance is a major obstacle in antitumor therapies. This study explores the effects and functional mechanisms of zDHHC palmitoyltransferase 13 (ZDHHC13) on radioresistance in nasopharyngeal carcinoma (NPC).
Xianjun Lin, Xinrong Hu, Shenhong Qu, Xiaoxue Wang, Haiyun Zhao, Lingping Kong, Jinzhong Huang, Li Zhang, Qing Wen, Xi Lei, Pan Zou   +10 more
doaj   +1 more source

NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance

Cell Discovery
Alternative polyadenylation (APA) is critical for shaping transcriptome diversity and modulating cancer therapeutic resistance. While lactate is a well-established metabolic signal in cancer progression, its role in APA regulation remains unclear.
Jinlong Lin, Yixin Yin, Jinghua Cao, Yiyang Zhang, Jiewei Chen, Rixin Chen, Bingxu Zou, Cijun Huang, Yongrui Lv, Shuidan Xu, Han Yang, Peng Lin, Dan Xie   +12 more
doaj   +1 more source

Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis

Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardiomyopathy, according to recent ...
Eman M. Embaby, Mohamed A. M. Ali, Mohamed Adel, Mohammad El-Nablaway, Yaser Hosny Ali Elewa, Maha Alhelf, Hany M. A. Sonpol, Wesam S. El-Saeed, Amal Fahmy Dawood, Khaled S. El-Bayoumi, Eman Serry Zayed, Manar A. Didamoony   +11 more
core   +1 more source

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations

The burden of cardiovascular disease is rising in the Asia-Pacific region, in contrast to falling cardiovascular disease mortality rates in Europe and North America.
Ngeow, Joanne, Mina, Theresia H, Foo, Roger SY, Lai, Vicky, Cheung, Christine, Tay, Kai Yi, Yu, Hanry, Lam, Max, Guan, Xue Li, Tay, Darwin, Best, James, Sarangarajan, Rangaprasad, Bertin, Nicolas, Low, Dorrain, Min, Yilin, Wong, Kari E, Wong, Eleanor, Chambers, John C, Jain, Pritesh R, Kota, Vishnu Goutham, Lee, Eng Sing, Ng, Hong Kiat, Sheridan, Patricia A, Sadhu, Nilanjana, Elliott, Paul, Riboli, Elio, Ackers-Johnson, Matthew, Michelotti, Gregory A, Lee, Chang Jie Mick, Thi, Thi Tun, Yang, Yang, Loh, Marie, Lee, Jimmy, Liu, Yan, Yu, Haojie, Tan, Patrick, Pakkiri, Leroy Sivappiragasam, Dalan, Rinkoo, Shi, Yu, Wang, Xiaoyan, Drum, Chester Lee   +40 more
core   +1 more source

Single-cell profiling and machine learning identify cuproptosis-related fibroblast subpopulations and fibrogenesis modulator AEBP1 in endometriosis. [PDF]

Apoptosis
Huang E, Li JT, Zuo D, Li R, Wu Q, Lin N, Zhao J, Wang H, Liu Y, Zhang L.   +9 more
europepmc   +1 more source