Results 111 to 120 of about 3,265 (192)

Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron–Sulfur Cluster Biosynthesis

, 2017
Ferredoxins play an important role as an electron donor in iron–sulfur (Fe–S) cluster biosynthesis. Two ferredoxins, human mitochondrial ferredoxin 1 (FDX1) and human mitochondrial ferredoxin 2 (FDX2), are present in the matrix of human mitochondria ...
Ronnie O. Frederick (579144), John L. Markley (178613), Kai Cai (1344477), Marco Tonelli (178598)   +3 more
core   +1 more source

Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis

Discover Oncology
Objectives Breast cancer patients with diabetes are often associated with poor prognosis. This study aims to investigate the role of metformin in ferroptosis and cuproptosis in diabetic breast cancer patients and explore its potential impact on clinical ...
Changwen Li, Tao Chen, Yuanyuan Li, Chunyan Zhou, Jing Du, Xiaoxin Li, Chuangang Tang, Cheng Ma, Na Deng, Huaixin Cui   +9 more
doaj   +1 more source

Client distribution between Chlamydomonas FDX1 and FDX2 in carbon, nitrogen and sulfur assimilation

ABSTRACT Plant-type ferredoxins (Fd) comprise small, soluble protein families that distribute electrons from photosystem I to various client proteins within the chloroplast stroma. In Chlamydomonas reinhardtii , the major, constitutively expressed FDX1/PetF supports Fd-NADP
Stefan Schmollinger, George Kusi-Appiah, David Villegas, Sarah Stainbrook, Thomas V. O’Halloran, Daniela Strenkert   +5 more
openaire   +3 more sources

lncRNA RP11-199F11.2 promotes high-grade serous ovarian cancer cell proliferation by regulating cuproptosis through FDX1

Scientific Reports
To elucidate the expression characteristics of the long noncoding RNA RP11-199F11.2 (RP11) in high-grade serous ovarian cancer (HGSOC) and its potential mechanism of regulating cancer progression via the copper-death pathway, and to evaluate the ...
Shishi Xu, Linping Wang, Yingying Wu, Yufang Xia, Lingzhi Wang, Xiao Yu, Xin Sun, Yanhui Lou   +7 more
doaj   +1 more source

p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation

Frontiers in Oncology
BackgroundCuproptosis, a novel cell death pathway mediated by ferredoxin 1 (FDX1) and protein lipoylation, has emerged as a valuable target in cancer therapy.
Xiao Liu, Honglin Qu, Jingmin Li, Xuhong Sun, Zhenlin Wang, Dong Wang, Xianyong Bai, Xiaoyan Li   +7 more
doaj   +1 more source

The signature genes of cuproptosis associates with tumor immune microenvironment and predicts prognosis in kidney renal clear cell carcinoma

Frontiers in Oncology
BackgroundCuproptosis is a new form of cell death, which has great potential to be developed in tumors treatment. Our study aimed to explore the predictive value of cuproptosis-related genes (CRGs) in various cancers, with a focus on kidney renal clear ...
Shuhan Liu, Shijie Lv, Xi Li, Weiguo Lu, Shengjie Chen   +4 more
doaj   +1 more source

Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis

Scientific Reports
This study delved into the role of the PI3K/AKT signaling pathway and cuproptosis in steroid-induced osteonecrosis of the femoral head (SIONFH), assessing the therapeutic potential of the PI3K agonist 740Y-P.
Shihua Gao, Haoran Zhu, Hongxing Chen, Hongduo Lu, Moshan Wen, Yinuo Fan, Deqiang Yang, Hu Li   +7 more
doaj   +1 more source

Ferredoxins: master regulators in mitochondrial redox homeostasis and programmed cell death

Redox Biology
Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe–S) proteins that serve as master regulators of mitochondrial redox homeostasis, governing critical processes including electron transfer, energy metabolism, Fe–S cluster biogenesis, and ...
Yajuan Lu, Yunyi Wu, Chen Yang, Yi Zhou, Xueying Ren, Haoran Li, Hangqi Huang, Feifan Pan, Aoli Deng, Yi Lu, Jiayi Yang, Xiangmin Tong, Yanchun Li, Jing Du   +13 more
doaj   +1 more source

FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells

Objective: Gastric cancer (GC) is a prevalent malignant tumor that warrants the development of drugs and therapeutic targets. Cuproptosis has emerged as a promising mechanism by which to inhibit tumors because copper homeostasis disorders frequently ...
Qiang Feng, Ming Hao, Dongxu Wang, Yi Guo, Liqun Sun, Jianfeng Mu, Gongliang Guo, Boqiang Tao, Chao Lin, Jiahuan Yuan, Hengzong Zhou, Qirong Li   +11 more
core   +1 more source

METTL3-mediated m6A modification of FDX1 confers resistance to cuproptosis and promotes hepatocellular carcinoma progression

Communications Biology
Cuproptosis, a copper-dependent cell death pathway, is emerging as a potential cancer treatment strategy. N6-methyladenosine (m6A), the predominant eukaryotic RNA modification, regulates various cell death mechanisms; however, its role in cuproptosis ...
Qian Jiang, Chen Peng, Wenhao Mao, Zhuo Yu, Yadan Feng, Yurui Li, Jialin Zhu, Jiao Zhao, Dan Liao, Ting Sun   +9 more
doaj   +1 more source