Results 121 to 130 of about 3,265 (192)

The Role of Cuproptosis in Hyperoxia-Induced Lung Injury and Its Potential for Treatment

Journal of Inflammation Research
Kaihua Yu,1,* Yunfei Gu,2,* Ying Yao,1 Jianchun Li,3 Suheng Chen,1 Hong Guo,4 Yulan Li,5 Jian Liu1,6 1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Anesthesiology Department, Gansu ...
Yu K, Gu Y, Yao Y, Li J, Chen S, Guo H, Li Y, Liu J   +7 more
doaj  

Engineered RAP-anchored copper-escorting liposomes for FDX1-targeted cuproptosis in glioblastoma therapy‌

Theranostics
Rationale: Glioblastoma multiforme (GBM), the most aggressive primary brain malignancy, presents considerable therapeutic challenges due to intrinsic treatment resistance and dismal clinical outcomes. Capitalizing on emerging insights into cuproptosis-mediated oncotherapy, we have developed a receptor-associated protein (RAP)-modified liposomal ...
Liu, Meng-Meng, Zhao, Ling-Xiao, Gong, Zhi-Qiang, He, Yi-Jiang, Jiang, Xue, Luo, Wei, Yu, Xin, Wang, Zhan-You   +7 more
openaire   +3 more sources

Expression of the chloroplastic FDX1 in different subcellular compartments of the green microalga Chlamydomonas reinhardtii

International audienceFerredoxins (FDXs) are small, soluble iron-sulfur (Fe-S) proteins involved in various metabolic pathways across diverse organisms. Among microalgae, the green microalgal model Chlamydomonas reinhardtii possesses a very large number ...
Sofia, Inturri, Yanis, Aoudache, Agustina, Terenzi, Claire, Remacle, Rouhier, Nicolas   +4 more
core  

UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1‐Mediated Cuproptosis, While Promoting M2 Macrophage Polarization

This study aims to investigate the biological function, molecular mechanisms, and impact on the tumor microenvironment of the ubiquitin‐conjugating enzyme E2S (UBE2S) in the progression of kidney renal clear cell carcinoma (KIRC).
Gang Jia, Lingxia Zhang, Zhizhong Zhang, Junru Chen, Yuelong Feng, Hao Yang, Yu Gao, Jiao Wei   +7 more
core   +1 more source

Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis

Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardiomyopathy, according to recent ...
Eman M. Embaby, Mohamed A. M. Ali, Mohamed Adel, Mohammad El-Nablaway, Yaser Hosny Ali Elewa, Maha Alhelf, Hany M. A. Sonpol, Wesam S. El-Saeed, Amal Fahmy Dawood, Khaled S. El-Bayoumi, Eman Serry Zayed, Manar A. Didamoony   +11 more
core   +1 more source

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations

The burden of cardiovascular disease is rising in the Asia-Pacific region, in contrast to falling cardiovascular disease mortality rates in Europe and North America.
Ngeow, Joanne, Mina, Theresia H, Foo, Roger SY, Lai, Vicky, Cheung, Christine, Tay, Kai Yi, Yu, Hanry, Lam, Max, Guan, Xue Li, Tay, Darwin, Best, James, Sarangarajan, Rangaprasad, Bertin, Nicolas, Low, Dorrain, Min, Yilin, Wong, Kari E, Wong, Eleanor, Chambers, John C, Jain, Pritesh R, Kota, Vishnu Goutham, Lee, Eng Sing, Ng, Hong Kiat, Sheridan, Patricia A, Sadhu, Nilanjana, Elliott, Paul, Riboli, Elio, Ackers-Johnson, Matthew, Michelotti, Gregory A, Lee, Chang Jie Mick, Thi, Thi Tun, Yang, Yang, Loh, Marie, Lee, Jimmy, Liu, Yan, Yu, Haojie, Tan, Patrick, Pakkiri, Leroy Sivappiragasam, Dalan, Rinkoo, Shi, Yu, Wang, Xiaoyan, Drum, Chester Lee   +40 more
core   +1 more source

Copper, cuproptosis, and cancer: biology concepts of a novel cell death. [PDF]

Apoptosis
Eshraghi R, Hosseini N, Yazdani MS, Badihi S, Pirmoradian P, Bahrami A, Darouei B, Ghanouni S, Lam AK, Hamblin MR.   +9 more
europepmc   +1 more source

A cuproptosis-inducing covalent organic framework synergizes with oncolytic virus for tumor radiotherapy. [PDF]

Nat Commun
Liu YT, Liu KS, Li H, Wang S, Bie SY, Wei YQ, Gou SS, Wan XB, Li XZ, Zhang L, He W.   +10 more
europepmc   +1 more source

Eriocitrin Attenuates Diabetic Cardiomyopathy by Regulating Copper Homeostasis and Cuproptosis-Associated Pathways via SIRT7/YAP/ATP7A Signalling. [PDF]

Basic Clin Pharmacol Toxicol
Chen L, Mao S, Yu Y, Zhang D, Fan Z.
europepmc   +1 more source

Copper Metabolism-Related Cell Death in Kidney Diseases: Molecular Mechanisms, Disease-Specific Evidence, and Translational Implications. [PDF]

Int J Mol Sci
Shao W, Wang Q, Liu Y, Li L, Li X, Wang X, Cheng F.   +6 more
europepmc   +1 more source