Results 101 to 110 of about 3,265 (192)

Image1_Characterization of the functional effects of ferredoxin 1 as a cuproptosis biomarker in cancer.jpeg

, 2022
Background: Cuproptosis is a recently discovered form of programmed cell death. Ferredoxin 1 (FDX1) is a key gene that mediates this process. However, the role of FDX1 in human tumors is not clear.Methods: We comprehensively analyzed the differential ...
Na Li (6550), Xiang Li (114679), Jincheng Liu (3627887), Guangjun Jiao (6575825), Zhenqian Sun (13862219), Hongxin Cao (298256), Zihan Dai (8606487)   +6 more
core   +1 more source

FDX1 overexpression inhibits the growth and metastasis of clear cell renal cell carcinoma by upregulating FMR1 expression

Cell Death Discovery
Kidney cancer has caused more than 150,000 deaths in 185 countries around the world and is a serious threat to human life. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. FDX1, a crucial gene for regulating copper death,
Wuping Yang, Cunjin Wu, Chaochao Jiang, Taile Jing, Minghao Lu, Dan Xia, Ding Peng   +6 more
doaj   +1 more source

miR‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Schematic diagram of the mechanism by which miR‐15a‐5p regulates glioblastoma progression through targeting GLS2 and modulating ferroptosis. miR‐15a‐5p regulates the ferroptosis pathway by targeting and inhibiting glutaminase 2 (GLS2) expression: Downregulation of miR‐15a‐5p leads to upregulation of GLS2, which promotes lipid peroxidation, accompanied ...
Yanyan Yu, Helan Yuan, Zikun Fang, Jinyuan Liao, Yancong Yang, Jun Liu, Wenjin Wei, Qiuhua Jiang   +7 more
wiley   +1 more source

Integrated profiling identifies ferredoxin 1 as an immune-related biomarker of malignant phenotype in glioma

Heliyon
Background: Glioma, a highly resistant and recurrent type of central nervous system tumor, poses a significant challenge in terms of effective drug treatments and its associated mortality rates.
Dongcheng Xie, Hailong Huang, Youwei Guo, Zhipeng Jiang, Yirui Kuang, Haoxuan Huang, Weidong Liu, Lei Wang, Zhaoqi Xin, Binbin Wang, Caiping Ren, Xingjun Jiang   +11 more
doaj   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

DataSheet1_Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.PDF

, 2022
Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is the key regulator in copper-dependent cell death.
Yang Wang (5921), Fengping Liu (1430389), Yuwei Zhang (388956), Peng Jiang (16544), Longfei Yang (435484), Ninghan Feng (107472)   +5 more
core   +1 more source

UBE2D4 Upregulation Promotes Cuproptosis Sensitivity in Colorectal Cancer

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
UBE2D4 is genetically upregulated in colorectal cancer and its expression status modulates copper‐induced cuproptosis sensitivity. Copper overload induces UBE2D4 and DLAT expression; UBE2D4 knockdown attenuates DLAT induction and rescues cell viability, suggesting UBE2D4 as a genetic determinant of cuproptosis sensitivity and a potential stratification
Biaoyu Wang, Chan Li, Xianwen Guo, Zhihai Liang   +3 more
wiley   +1 more source

DataSheet2_Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.xlsx

, 2022
Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is the key regulator in copper-dependent cell death.
Yang Wang (5921), Fengping Liu (1430389), Yuwei Zhang (388956), Peng Jiang (16544), Longfei Yang (435484), Ninghan Feng (107472)   +5 more
core   +1 more source

LIPE‐AS1 Facilitates Prostate Cancer Progression via Suppressing Cuproptosis Through the miR‐330‐3p/MGAT5 Axis

MedComm – Oncology, Volume 5, Issue 3, September 2026.
LIPE‐AS1 is markedly upregulated and serves as a competitive endogenous RNA that sponges miR‐330‐3p. This sequestration relieves miR‐330‐3p‐mediated repression of MGAT5, leading to elevated MGAT5, which subsequently suppresses cuproptosis‐related proteins FDX1, DLAT, and DLST, thus diminishing cuproptosis sensitivity.
Qiang Shen, Qu Leng, Kaihui Wu, Guorui Li, Yiyou Mao, Jun Wu, Ziyi Song, Zhihai Deng, Hangyang Peng, Jun Zou, Jiamin Wang, Ping Liu, Zihao Zou, Zhaojun Pan, Jianfeng Zhong, Yubin Li, Nan Deng, Xiangming Mao, Daojun Lv   +18 more
wiley   +1 more source

Atractylenolide III mitigates polycystic ovary syndrome by activating FDX1-mediated proliferation of ovarian granulocyte cells via PI3K/AKT/mTOR

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder among women of reproductive age worldwide. This study aimed to investigate the therapeutic potential and molecular mechanisms of Atractylenolide III (ATL-III),
Nan Zhou, Wei Tai, Wenqiang Lv, Qing He, Shiwen He, Kexin Chen, Qing Wang, Jingbo Zhang, Suyan Li, Yijuan Cao, Xueyan Zhou   +10 more
doaj   +1 more source