Results 101 to 110 of about 2,914 (186)

FDX1 overexpression inhibits the growth and metastasis of clear cell renal cell carcinoma by upregulating FMR1 expression

Cell Death Discovery
Kidney cancer has caused more than 150,000 deaths in 185 countries around the world and is a serious threat to human life. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. FDX1, a crucial gene for regulating copper death,
Wuping Yang, Cunjin Wu, Chaochao Jiang, Taile Jing, Minghao Lu, Dan Xia, Ding Peng   +6 more
doaj   +1 more source

Integrated profiling identifies ferredoxin 1 as an immune-related biomarker of malignant phenotype in glioma

Heliyon
Background: Glioma, a highly resistant and recurrent type of central nervous system tumor, poses a significant challenge in terms of effective drug treatments and its associated mortality rates.
Dongcheng Xie, Hailong Huang, Youwei Guo, Zhipeng Jiang, Yirui Kuang, Haoxuan Huang, Weidong Liu, Lei Wang, Zhaoqi Xin, Binbin Wang, Caiping Ren, Xingjun Jiang   +11 more
doaj   +1 more source

DataSheet2_Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.xlsx

, 2022
Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is the key regulator in copper-dependent cell death.
Yang Wang (5921), Fengping Liu (1430389), Yuwei Zhang (388956), Peng Jiang (16544), Longfei Yang (435484), Ninghan Feng (107472)   +5 more
core   +1 more source

Table1_FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis.XLSX

, 2022
Ferredoxin 1 (FDX1), an iron-sulphur protein, is responsible for electron transfer in a range of metabolic redox reactions. Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer characterised by metabolic reprogramming, and FDX1 is a critical ...
Jiali Ye (6828962), Yan Huang (46805), Baojun Wang (172491), Tao Wang (12008), Huayi Feng (12532510), Xin Ma (37268), Xu Zhang (49484), Xing Huang (129439), Xiangyi Zhang (744989)   +8 more
core   +1 more source

Image2_FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis.TIF

, 2022
Ferredoxin 1 (FDX1), an iron-sulphur protein, is responsible for electron transfer in a range of metabolic redox reactions. Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer characterised by metabolic reprogramming, and FDX1 is a critical ...
Jiali Ye (6828962), Yan Huang (46805), Baojun Wang (172491), Tao Wang (12008), Huayi Feng (12532510), Xin Ma (37268), Xu Zhang (49484), Xing Huang (129439), Xiangyi Zhang (744989)   +8 more
core   +1 more source

Image1_FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis.TIF

, 2022
Ferredoxin 1 (FDX1), an iron-sulphur protein, is responsible for electron transfer in a range of metabolic redox reactions. Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer characterised by metabolic reprogramming, and FDX1 is a critical ...
Jiali Ye (6828962), Yan Huang (46805), Baojun Wang (172491), Tao Wang (12008), Huayi Feng (12532510), Xin Ma (37268), Xu Zhang (49484), Xing Huang (129439), Xiangyi Zhang (744989)   +8 more
core   +1 more source

Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron–Sulfur Cluster Biosynthesis

, 2017
Ferredoxins play an important role as an electron donor in iron–sulfur (Fe–S) cluster biosynthesis. Two ferredoxins, human mitochondrial ferredoxin 1 (FDX1) and human mitochondrial ferredoxin 2 (FDX2), are present in the matrix of human mitochondria ...
Ronnie O. Frederick (579144), John L. Markley (178613), Kai Cai (1344477), Marco Tonelli (178598)   +3 more
core   +1 more source

Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis

Discover Oncology
Objectives Breast cancer patients with diabetes are often associated with poor prognosis. This study aims to investigate the role of metformin in ferroptosis and cuproptosis in diabetic breast cancer patients and explore its potential impact on clinical ...
Changwen Li, Tao Chen, Yuanyuan Li, Chunyan Zhou, Jing Du, Xiaoxin Li, Chuangang Tang, Cheng Ma, Na Deng, Huaixin Cui   +9 more
doaj   +1 more source

p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation

Frontiers in Oncology
BackgroundCuproptosis, a novel cell death pathway mediated by ferredoxin 1 (FDX1) and protein lipoylation, has emerged as a valuable target in cancer therapy.
Xiao Liu, Honglin Qu, Jingmin Li, Xuhong Sun, Zhenlin Wang, Dong Wang, Xianyong Bai, Xiaoyan Li   +7 more
doaj   +1 more source

The signature genes of cuproptosis associates with tumor immune microenvironment and predicts prognosis in kidney renal clear cell carcinoma

Frontiers in Oncology
BackgroundCuproptosis is a new form of cell death, which has great potential to be developed in tumors treatment. Our study aimed to explore the predictive value of cuproptosis-related genes (CRGs) in various cancers, with a focus on kidney renal clear ...
Shuhan Liu, Shijie Lv, Xi Li, Weiguo Lu, Shengjie Chen   +4 more
doaj   +1 more source