Results 61 to 70 of about 179,106 (262)

STUDIES ON IRON-PROTEIN METABOLISM WITH RADIOIRON (Fe-55 and Fe-59)

The Japanese Journal of Physiology, 1955
1. In the control group, the turnover rate of hemoglobin radioiron was higher than the appearance of ferritin radioiron in tissues.2. In tne early stage of the acute hemolytic anemia group, the turnover rate of hemoglobin radioiron was higher than the control group and disappearance of hemoglobin radioiron also faster.3.
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Overview of Protein and Fe Intake With The Event of Anemia In Adolescent: Systematic Review

Placentum, 2023
Background: Adolescents are a group that is prone to anemia. Anemia is defined as a lower than normal haemoglobin level. The prevalence of anemia in adolescents in Indonesia is the highest at the age group of 15-24 years, 32%.
Cantika Erningtyas, Rize Budi Amalia, Zakiyatul Faizah   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

An ethylene response factor (MxERF4) functions as a repressor of Fe acquisition in Malus xiaojinensis

Scientific Reports, 2018
Iron (Fe) is an essential element for plants; however, its availability is limited as it forms insoluble complexes in the soil. Consequently, plants have developed mechanisms to adapt to low Fe conditions.
Wei Liu, Ting Wu, Qiwei Li, Xinzhong Zhang, Xuefeng Xu, Tianhong Li, Zhenhai Han, Yi Wang   +7 more
doaj   +1 more source

Fe Protein-Independent Substrate Reduction by Nitrogenase MoFe Protein Variants

Biochemistry, 2015
The reduction of substrates catalyzed by nitrogenase normally requires nucleotide-dependent Fe protein delivery of electrons to the MoFe protein, which contains the active site FeMo cofactor. Here, it is reported that independent substitution of three amino acids (β-98(Tyr→His), α-64(Tyr→His), and β-99(Phe→His)) located between the P cluster and FeMo ...
Danyal, Karamatullah, Rasmussen, Andrew J., Keable, Stephen M., Inglet, Boyd S., Shaw, Studipta, Zadvornyy, Oleg A., Duval, Simon, Dean, Dennis R., Raugei, Simone, Peters, John W., Seefeldt, Lance C.   +10 more
openaire   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mitochondrial ferritin is a functional iron-storage protein in cucumber (Cucumis sativus) roots

Frontiers in Plant Science, 2013
In plants, intracellular Fe trafficking must satisfy chloroplasts’ and mitochondrial demands for Fe without allowing its accumulation in the organelles in dangerous redox-active forms. Protein ferritin is involved in such homeostatic control, however its
GIANPIERO eVIGANI, Delia eTarantino, IRENE eMURGIA   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Mitochondria function in cytoplasmic FeS protein biogenesis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Iron‑sulfur (FeS) clusters are cofactors of numerous proteins involved in essential cellular functions including respiration, protein translation, DNA synthesis and repair, ribosome maturation, anti-viral responses, and isopropylmalate isomerase activity.
Andrew, Dancis, Ashutosh K, Pandey, Debkumar, Pain   +2 more
openaire   +2 more sources