Results 81 to 90 of about 234,528 (304)
Long Term Effects of Chronic Variable Stress Administered during Different Developmental Stages in Mice [PDF]
, 2011 A number of studies have suggested that the occurrence of past trauma can increase an individual\u27s chance of developing PTSD from a new traumatic experience later in life.
Boeh, Henry
core +1 more source
Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females [PDF]
, 2014 Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction.
Bredy, Timothy W. +5 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Fear Conditioning and Extinction: Examining the Role of GSK3β ser 389 [PDF]
, 2016 GSK3β is a serine threonine kinase that has been shown to influence numerous biological and psychological interactions, including the regulation of cell survival and cell death, as well as influencing mood disorders such as major depressive disorder and ...
Liebman, Benjamin
core +1 more source
Fear Conditioning Potentiates Synaptic Transmission onto Long-Range Projection Neurons in the Lateral Subdivision of Central Amygdala [PDF]
, 2014 Recent studies indicate that the lateral subdivision of the central amygdala (CeL) is essential for fear learning. Specifically, fear conditioning induces cell-type-specific synaptic plasticity in CeL neurons that is required for the storage of fear ...
Li, B., Penzo, M. A., Robert, V.
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Role of p38 MAPK inhibitor in conditioned fear [PDF]
, 2015 p38 mitogen activated protein kinase (p38) is a kinase that has been implicated in cellular plasticity, stress, and psychiatric disorders and recently in the process of DNA repair.
Bauman, Brittany Nicole +1 more
core +1 more source
Central Amygdala Somatostatin Neurons Gate Passive and Active Defensive Behaviors [PDF]
, 2016 The central amygdala (CeA) has a key role in learning and expression of defensive responses. Recent studies indicate that somatostatin-expressing (SOM(+)) neurons in the lateral division of the CeA (CeL) are essential for the acquisition and recall of ...
Albeanu, D. F. +3 more
core +1 more source
Extinction of Fear Memory Attenuates Conditioned Cardiovascular Fear Reactivity [PDF]
Frontiers in Behavioral Neuroscience, 2018 Post-traumatic stress disorder (PTSD) is characterized by a heightened emotional and physiological state and an impaired ability to suppress or extinguish traumatic fear memories. Exaggerated physiological responses may contribute to increased cardiovascular disease (CVD) risk in this population, but whether treatment for PTSD can offset CVD risk ...
Adam P. Swiercz +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source