Results 71 to 80 of about 9,527 (221)

Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study). [PDF]

, 2016
Determine the efficacy and safety of daily lesinurad (200 or 400 mg orally) added to allopurinol in patients with serum uric acid (sUA) above target in a 12-month, randomised, phase III trial.
Adler, S., Bardin, T., Baumgartner, S., Bhakta, N., Fung, M., Keenan, R.T., Khanna, P.P., Kopicko, J., So, A., Storgard, C.   +9 more
core   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Antiurolithiatic Potential of a Series of Phthalimide Derivatives on Calcium Oxalate Crystals

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Urolithiasis, primarily caused by calcium oxalate crystals, represents a major health concern due to high recurrence rates and limitations of current treatments in dissolving existing stones. This study investigated the antiurolithiatic potential of 15 phthalimide derivatives against calcium oxalate monohydrate (COM) and dihydrate (COD ...
Daniele Regina Sonza, Laura Von Borell du Vernay França, Rita de Cássia Vilhena da Silva, Anelize Dada, Mariana Zanovello, Thaise Boeing, Priscila de Souza, Rogério Correa   +7 more
wiley   +1 more source

Febuxostat methanol solvate

Acta Crystallographica Section E, 2011
In the title compound {systematic name: [2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid (febuxostat) methanol monosolvate}, C16H16N2O3S·CH4O, the benzene and thiazole rings in the febuxostat molecule are twisted at 5.3 ...
Qi-Ying Jiang, Jing-Jing Qian, Jian-Ming Gu, Gu-Ping Tang, Xiu-Rong Hu   +4 more
doaj   +1 more source

POS0520 CARDIOVASCULAR SAFETY OF FEBUXOSTAT IN PATIENTS WITH GOUT OR HYPERURICEMIA: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS [PDF]

, 2023
R. Ghossan, O. Aitisha, Fouad Fayad, Pascal Richette, Thomas Bardin   +4 more
openalex   +1 more source

Retroperitoneal Dedifferentiated Liposarcoma With Penetrating Abscess Formation Secondary to Ileal Invasion: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Liposarcoma is a relatively common malignant soft tissue tumor in adults. Dedifferentiated liposarcoma (DLS) is a particularly invasive subtype characterized by high recurrence rates and a poor prognosis. We describe a case of a retroperitoneal liposarcoma with poor differentiation that presented with peritonitis accompanied by ileal ...
Kenichiro Yambe, Kei Nakagawa, Kuniharu Yamamoto, Hiroto Sakurai, Kazuhiro Takami, Noriko Kondo, Chikashi Shibata, Yu Katayose   +7 more
wiley   +1 more source

Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study

Arthritis Research & Therapy, 2019
Background For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment.
Amayelle Rey, Benjamin Batteux, Solène M. Laville, Justine Marienne, Kamel Masmoudi, Valérie Gras-Champel, Sophie Liabeuf   +6 more
doaj   +1 more source

Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature [PDF]

, 2017
BACKGROUND: This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor. CASE PRESENTATION: A 65-year-old white woman had tumor lysis syndrome, which represent a dangerous oncological emergency.
Giulia Malaguarnera, Michele Malaguarnera, Michele Vecchio, Roberto Madeddu, Saverio Latteri, Vito Emanuele Catania   +5 more
core   +1 more source

Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley   +1 more source

Severe Hypouricemia Impairs Endothelium‐Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo‐Controlled, and Crossover Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Uric acid (UA) is a plasmatic antioxidant that has possible effects on blood pressure. The effects of UA on endothelial function are unclear. We hypothesize that endothelial function is not impaired unless significant UA depletion is achieved ...
Benjamin De Becker, Catherine Coremans, Martin Chaumont, Cédric Delporte, Pierre Van Antwerpen, Thierry Franck, Alexandre Rousseau, Karim Zouaoui Boudjeltia, Pierre Cullus, Philippe van de Borne   +9 more
doaj   +1 more source