Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma [PDF]
, 2017 Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation ...
Alessandro Fanzani, Maura Poli
openalex +3 more sources
Regulatory mechanism of ferroptosis, a new mode of cell death [PDF]
, 2019 Ferroptosis is a newly discovered process of cell death that differs from apoptosis, autophagy, and pyroptosis. It is closely related to tumor formation, diseases that damage tissue, and neurodegenerative diseases.
Da Liu +5 more
openalex +3 more sources
Genomic analysis uncovers prognostic and immunogenic characteristics of ferroptosis for clear cell renal cell carcinoma [PDF]
Molecular Therapy: Nucleic Acids, 2021 In this study, the characteristic patterns of ferroptosis in clear cell renal cell carcinoma (ccRCC) were systematically investigated with the interactions between ferroptosis and the tumor microenvironment (TME).
Dan Bai +6 more
doaj +3 more sources
Ferroptosis-mediated immune responses in osteoporosis. [PDF]
J Orthop TranslatOsteoporosis is a common systemic metabolic disease, characterized by decreased bone mass and susceptibility to fragility fractures, often associated with aging, menopause, genetics, and immunity.
Xiao W, Yike W, Gongwen L, Youjia X.
europepmc +2 more sources
Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer. [PDF]
Cell Death DisFerroptosis, a novel form of regulated cell death induced by the excessive accumulation of lipid peroxidation products, plays a pivotal role in the suppression of tumorigenesis.
Deng R +11 more
europepmc +2 more sources
Programming a Ferroptosis‐to‐Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy [PDF]
Advanced ScienceFerroptosis and apoptosis are key cell‐death pathways implicated in several human diseases including cancer. Ferroptosis is driven by iron‐dependent lipid peroxidation and currently has no characteristic biomarkers or gene signatures.
Yaron Vinik +11 more
doaj +3 more sources
Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Frontiers in Pharmacology, 2023 Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various diseases, particularly tumors, organ injury, and degenerative pathologies.
Fei Li, Pei-Feng Li, Xiao-Dan Hao
doaj +1 more source
Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors
Frontiers in Oncology, 2023 The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and poor prognosis, and the incidence and death rate is increasing yearly.
Yansheng Yao +7 more
doaj +1 more source
Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies [PDF]
PeerJ, 2022 Research on the biological role of exosomes is rapidly developing, and recent evidence suggests that exosomal effects involve ferroptosis. Exosomes derived from different tissues inhibit ferroptosis, which increases tumour cell chemoresistance. Therefore,
Yixin Shi +7 more
doaj +2 more sources
Ferroptosis Patterns and Tumor Microenvironment Infiltration Characterization in Bladder Cancer
Frontiers in Cell and Developmental Biology, 2022 Background: Ferroptosis is a unique iron-dependent form of cell death and bladder cancer (BCa) is one of the top ten most common cancer types in the world.
Qi-Dong Xia +8 more
doaj +1 more source