Results 1 to 10 of about 115,871 (339)
Cell Reports, 2023 Summary: Solid tumors have developed robust ferroptosis resistance. The mechanism underlying ferroptosis resistance regulation in solid tumors, however, remains elusive.
Zhou Yang +11 more
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Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors
Frontiers in Oncology, 2023 The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and poor prognosis, and the incidence and death rate is increasing yearly.
Yansheng Yao +7 more
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Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies [PDF]
PeerJ, 2022 Research on the biological role of exosomes is rapidly developing, and recent evidence suggests that exosomal effects involve ferroptosis. Exosomes derived from different tissues inhibit ferroptosis, which increases tumour cell chemoresistance. Therefore,
Yixin Shi +7 more
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Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Frontiers in Pharmacology, 2023 Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various diseases, particularly tumors, organ injury, and degenerative pathologies.
Fei Li, Pei-Feng Li, Xiao-Dan Hao
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Cross Talk Between Ferroptosis and Cerebral Ischemia
Frontiers in Neuroscience, 2020 Recently, ferroptosis has been revealed as a new form of regulated cell death. Distinct from apoptosis and necrosis, ferroptosis is evoked by iron-dependent lipid peroxidation.
Xu She, Bin Lan, Haomei Tian, Biao Tang
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Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries
Antioxidants, 2023 Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases.
Wentao Duan +11 more
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Induction and application of ferroptosis in cancer therapy
Cancer Cell International, 2022 At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid peroxidation-driven regulated cell death pathway.
Qing Nie +4 more
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The Mechanism of Ferroptosis and Applications in Tumor Treatment
Frontiers in Pharmacology, 2020 Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ...
Xinyue Lin +4 more
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Role of ferroptosis on tumor progression and immunotherapy
Cell Death Discovery, 2022 Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by activation of antioxidant signaling pathways such as SLC7A11/GPX4 axis ...
Deting Gong +4 more
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Autophagy mediates an amplification loop during ferroptosis
Cell Death and Disease, 2023 Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is ...
Seunghee Lee +5 more
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