Results 1 to 10 of about 154,945 (241)

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. [PDF]

Nature, 2019
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
A Arroyo, Bingqi Tong, BR Stockwell, Breanna Ford, Daniel K. Nomura, DL Tribble, DW Morgens, I Ingold, James A. Olzmann, JL Macdonald, Joseph M. Hendricks, K Bersuker, K Shimada, Kirill Bersuker, KR Marshall, L Magtanong, Leslie Magtanong, M Hayano, M Wu, Melissa A. Roberts, MG Rees, Michael C. Bassik, MJ Hangauer, Peter H. Tang, PH Tang, R Stocker, Roberto Zoncu, Scott J. Dixon, SJ Dixon, SJ Dixon, SJ Dixon, T Inoue, T Inoue, T Takahashi, TB Nguyen, Thomas J. Maimone, VS Viswanathan, WS Yang, WS Yang, X Sun, Y Ohiro, Y Zhang, Y Zou, Zhipeng Li   +43 more
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The diversified role of mitochondria in ferroptosis in cancer

Cell Death and Disease, 2023
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012.
Yu’e Liu, Shiping Lu, Lei-lei Wu, Liang Yang, Lixue Yang, Jinghan Wang   +5 more
doaj   +2 more sources

Novel insights on targeting ferroptosis in cancer therapy [PDF]

Biomarker Research, 2020
Ferroptosis belongs to a novel form of regulated cell death. It is characterized by iron dependence, destruction of intracellular redox balance and non-apoptosis. And cellular structure and molecules level changes also occur abnormally during ferroptosis.
Sipeng Zuo, Jie Yu, Hui Pan, Linna Lu
doaj   +2 more sources

Targeting ferroptosis opens new avenues for the development of novel therapeutics

Signal Transduction and Targeted Therapy, 2023
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation.
Shumin Sun, Jie Shen, Jianwei Jiang, Fudi Wang, Junxia Min   +4 more
doaj   +2 more sources

Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation

Cell Death Discovery
Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron accumulation and lipid peroxidation-induced damage. This mode of cell death differentiates from classical programmed cell death in terms of morphology and ...
Xin Jin, Jiuren Tang, Xiangyu Qiu, Xiaoya Nie, Shengming Ou, Geyan Wu, Rongxin Zhang, Jinrong Zhu   +7 more
doaj   +2 more sources

HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

Cell Reports, 2023
Summary: Solid tumors have developed robust ferroptosis resistance. The mechanism underlying ferroptosis resistance regulation in solid tumors, however, remains elusive.
Zhou Yang, Wei Su, Xiyi Wei, Shuang Qu, Dan Zhao, Jingwan Zhou, Yunjun Wang, Qing Guan, Chao Qin, Jun Xiang, Ke Zen, Bing Yao   +11 more
doaj   +1 more source

Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors

Frontiers in Oncology, 2023
The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and poor prognosis, and the incidence and death rate is increasing yearly.
Yansheng Yao, Peng Ji, Hao Chen, Jianwen Ge, Yajing Xu, Peng Wang, Li Xu, Zhirong Yan   +7 more
doaj   +1 more source

Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies [PDF]

PeerJ, 2022
Research on the biological role of exosomes is rapidly developing, and recent evidence suggests that exosomal effects involve ferroptosis. Exosomes derived from different tissues inhibit ferroptosis, which increases tumour cell chemoresistance. Therefore,
Yixin Shi, Bingrun Qiu, Linyang Huang, Jie Lin, Yiling Li, Yiting Ze, Chenglong Huang, Yang Yao   +7 more
doaj   +2 more sources

Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease

Frontiers in Pharmacology, 2023
Ferroptosis, an iron-dependent non-apoptotic form of cell death, is reportedly involved in the pathogenesis of various diseases, particularly tumors, organ injury, and degenerative pathologies.
Fei Li, Pei-Feng Li, Xiao-Dan Hao
doaj   +1 more source

Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries

Antioxidants, 2023
Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases.
Wentao Duan, Zexian Ou, Yuxing Huang, Yifan Zhang, Lan Zhang, Yanan Zhao, Ruikun He, Yihan Zhang, Yuanlong Ge, Huiling Lou, Zhenyu Ju, Qian Hu   +11 more
doaj   +1 more source