NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis [PDF]
, 2017 Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential ...
Adams, Sylvia +8 more
core +1 more source
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis
mBio, 2023 Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous system (CNS), including encephalitis.
Xi-Qiu Xu +9 more
doaj +1 more source
A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids [PDF]
, 2016 Reactive oxygen species act as important second messengers in cell signaling and homeostasis through the oxidation of protein thiols. However, the dynamic nature of protein oxidation and the lack of sensitivity of existing molecular probes have hindered ...
Hartley, Richard C. +4 more
core +2 more sources
Phase separation of FSP1 promotes ferroptosis
Nature, 2023 Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour entities including therapy-refractory and dedifferentiating cancers^ 1 – 3 .
Toshitaka Nakamura +12 more
semanticscholar +1 more source
Modelling ferroptosis in IPEC-J2 cells: insights into iron-dependent cell death
Italian Journal of Animal ScienceFerroptosis, a form of regulated cell death characterised by iron accumulation and lipid peroxidation, plays a crucial role in various diseases. However, its mechanisms in livestock, particularly in pigs, remain unclear.
Ching-Hsuan Liu, Yuan-Yu Lin
doaj +1 more source
Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging
Bioactive MaterialsFerroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles ...
Min Jun Ko +7 more
doaj +1 more source
Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway
Nano Convergence, 2021 Iron-based nanoparticles, which could elicit ferroptosis, is becoming a promising new way to inhibit tumor cell growth. Notably, ultrasmall iron oxide nanoparticles (USIONPs) have been found to upregulate the autophagy process in glioblastoma (GBM) cells.
Jian Wen +5 more
doaj +1 more source
Circulation, 2023 Background: Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to myocardial cell loss and fibrosis. Prevention of cell death is important to protect cardiac function after I/R injury.
Wenbin Cai +9 more
semanticscholar +1 more source
Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles [PDF]
, 2018 Nanoparticles (NPs) typically accumulate in lysosomes. However, their impact on lysosomal function, as well as autophagy, a lysosomal degradative pathway, is still not well known.
Boya, Patricia +2 more
core +19 more sources
BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection
Pharmacological Research, 2022 Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the excessive lipid peroxidation accumulation.
Yue Chen +11 more
doaj +1 more source