Results 81 to 90 of about 8,735 (117)

Fibroblast-like Synoviocytes – Actors in Osteoimmunology

Osteologie, 2021
AbstractRheumatoid arthritis (RA) is an immune mediated inflammatory disease (IMID), characterized by chronic inflammation and irreversible bone loss. Studies have shown that fibroblast-like synoviocytes (FLS), a key cell population in the pathogenesis of RA, have an impact on balancing bone ...
Denise Beckmann, Adelheid Korb-Pap, Corinna Wehmeyer   +2 more
openaire   +1 more source

Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes

International Immunopharmacology, 2019
Rheumatoid arthritis is a common autoimmune disease primarily characterized by chronic inflammation, the formation of an invasive pannus, and destruction of the joints. In the present study, we employed real-time PCR and western blot analysis to investigate the role of dulaglutide in human fibroblast-like synoviocytes (FLS).
Weizhuo, Zheng, Haile, Pan, Li, Wei, Feng, Gao, Xiaozong, Lin   +4 more
openaire   +2 more sources

Telomerase-transduced osteoarthritic fibroblast-like synoviocyte cell line

Biochemical and Biophysical Research Communications, 2004
To examine whether the life span of fibroblast-like synoviocytes (FLSs) can be extended and to establish FLS cell lines that preserve the characteristics of primary FLSs, we introduced human catalytic subunit of telomerase (hTERT) gene into human osteoarthritic (OA) FLSs.
Yubo, Sun, Gary S, Firestein, Leonor, Wenger, Chun-Yuh C, Huang, Herman S, Cheung   +4 more
openaire   +2 more sources

Taurochenodeoxycholic acid induces apoptosis of fibroblast-like synoviocytes

European Journal of Pharmacology, 2013
Recent evidences have suggested that the paucity of the apoptosis of fibroblast-like synoviocytes (FLS) may contribute to the pathogenesis of rheumatoid arthritis. Apoptosis induction of rheumatoid arthritis FLS is therefore suggested as a potential therapeutic approach for rheumatoid arthritis.
Lei, Li, Chang, Liu, Mingqiang, Liu, Linkai, Shi, Qian, Liu, Hong, Guan, Peifeng, Li   +6 more
openaire   +2 more sources

Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes

International Immunopharmacology, 2021
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects synovial joints. During the course of RA, the synovium transforms into hyperplastic invasive tissue, leading to cartilage and bone destruction. Fibroblast-like synoviocytes (FLS) in the synovial lining develop aggressive phenotypes and produce pathogenic mediators ...
Zewen, Wu, Dan, Ma, Helin, Yang, Jinfang, Gao, Gailian, Zhang, Ke, Xu, Liyun, Zhang   +6 more
openaire   +2 more sources

A1.16 Interleukin-36α activates fibroblast like synoviocytes

Annals of the Rheumatic Diseases, 2014
Background Interleukin-36α (IL-36α) is a member of the IL-1 family and has pro-inflammatory properties. It binds to the IL-36 receptor (IL-36R) whereby the IL-1 receptor accessory protein (IL-1RacP) is recruited to form a heterodimeric receptor. In transfected cell lines this binding activates MAP-kinases and NF-κB signalling and further induces the ...
Verena Kästele, Olga Wagner, Anja Derer, Verena Schmitt, Georg Schett, Silke Frey, Axel J Hueber   +6 more
openaire   +1 more source

Serum amyloid A production by chicken fibroblast-like synoviocytes

Veterinary Immunology and Immunopathology, 2005
In brown chicken with chronic inflammatory processes of the joints amyloid arthropathy easily develops. The amyloid has been shown to be of the AA type which is derived from serum amyloid A (SAA). The aim of the present study was to investigate whether fibroblast-like synoviocytes (FLS) originating from brown chicken and other chicken breeds express ...
Upragarin, Narin, Asten, Alphonsus J A M van, J Tooten, Peter C, M Landman, Wil J, Gruys, Erik   +4 more
openaire   +3 more sources

Parthenolide Inhibits Proliferation of Fibroblast-Like Synoviocytes In Vitro

Inflammation, 2008
Parthenolide is a bioactive constituent of an aromatic herb Feverfew (Tanacetum parthenium). It has been found that both parthenolide and extract of feverfew have anti-inflammatory and antinociceptive properties. Moreover, they demonstrate antiproliferative activities on different human tumour cells.
Jolanta, Parada-Turska, Agata, Mitura, Wojciech, Brzana, Mirosław, Jabłoński, Maria, Majdan, Wojciech, Rzeski   +5 more
openaire   +2 more sources

Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation.

Clinical and experimental rheumatology, 2007
In vitro models for joint diseases often focus on a single cell type, such as chondrocytes in osteoarthritis (OA) or fibroblast-like synoviocytes (synoviocytes) in rheumatoid arthritis (RA). However, these joint diseases affect the whole joint and interaction between chondrocytes and synoviocytes may play an important role in disease pathology.
Steenvoorden, M.M.C., Bank, R.A., Ronday, H.K., Toes, R.E.M., Huizinga, T.W.J., DeGroot, J.   +5 more
openaire   +3 more sources

Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes

Journal of Cellular Biochemistry, 2018
AbstractBackgroundFibroblast‐like synoviocytes (FLSs) play an essential role in the chronic inflammatory process of rheumatoid arthritis (RA). Carvacrol is a natural monoterpenic phenol that retains significant anti‐inflammatory activity. However, the effect of carvacrol on inflammatory response in RA‐FLSs has not yet been reported.
Yu Li, Jian‐zhong Xu, Chen‐xi Gu, Guan‐lei Liu, Ke Tian   +4 more
openaire   +2 more sources