Results 11 to 20 of about 665,368 (391)

Biology of FGFRL1, the fifth fibroblast growth factor receptor [PDF]

Cellular and Molecular Life Sciences, 2010
FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of the FGFR family. It contains three extracellular Ig-like domains similar to the classical FGFRs, but it lacks the protein tyrosine kinase domain and instead contains a short intracellular tail with a peculiar histidine-rich motif. The gene for FGFRL1 is found in
Trueb, Beat
openaire   +7 more sources

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth [PDF]

Cell, 1996
Endochondral ossification is a major mode of bone formation that occurs as chondrocytes undergo proliferation, hypertrophy, cell death, and osteoblastic replacement.
C. Deng, A. Wynshaw-Boris, Fen Zhou, A. Kuo, P. Leder   +4 more
semanticscholar   +2 more sources

Functions of fibroblast growth factors and their receptors [PDF]

Current Biology, 1995
Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their ...
Wilkie, A, Morriss-Kay, G, Jones, E, Heath, J   +3 more
openaire   +3 more sources

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

Frontiers in Pharmacology, 2021
Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding.
Yanan Liu, Yanan Liu, Canwei Wang, Jifa Li, Jiandong Zhu, Chengguang Zhao, Chengguang Zhao, Huanhai Xu   +7 more
doaj   +1 more source

Dual Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Inhibition Elicits Antitumor Immunity and Enhances Programmed Cell Death-1 Checkpoint Blockade in Hepatocellular Carcinoma

Liver Cancer, 2020
Background and Aims: Combining anti-angiogenic therapy with immune checkpoint blockade with anti-programmed cell death-1 (PD-1) antibodies is a promising treatment for hepatocellular carcinoma (HCC).
Hai-Jing Deng, Anna Kan, N. Lyu, Luwen Mu, Yi Han, Longzhong Liu, Yanyu Zhang, Youfa Duan, Shuangye Liao, Shaolong Li, Qiankun Xie, Tianxiao Gao, Yanrong Li, Zhenfeng Zhang, Ming Zhao   +14 more
semanticscholar   +1 more source

Fibroblast Growth Factor Receptor (FGFR) Inhibitors in Urothelial Cancer

The Oncologist, 2020
Dysregulated fibroblast growth factor receptor (FGFR) signaling is associated with several cancers, including urothelial carcinoma. Preclinical studies with FGFR inhibitors have shown significant antitumor activity, which has led to clinical evaluation ...
R. Garje, Josiah J. An, M. Obeidat, Kranthi Kumar, Hesham Yasin, Y. Zakharia   +5 more
semanticscholar   +1 more source

Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct

Animals, 2021
The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo, Maria Rosa Rebordão, Ana Amaral, Carina Fernandes, António Galvão, Elisabete Silva, Pedro Pessa-Santos, Graça Alexandre-Pires, Rosário P. Roberto da Costa, Dariusz J. Skarzynski, Graça Ferreira-Dias   +10 more
doaj   +1 more source

Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling

Cells, 2021
FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling must be strictly controlled in order to induce the correct biological ...
Patrycja Szybowska, Michal Kostas, Jørgen Wesche, Ellen Margrethe Haugsten, Antoni Wiedlocha   +4 more
doaj   +1 more source

Fibroblast growth factors, their receptors and signaling. [PDF]

Endocrine-related cancer, 2000
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where they can bind to the heparan-like glycosaminoglycans (HLGAGs) of the ...
S W McLeskey, Ciaran Powers, Anton Wellstein   +2 more
openaire   +3 more sources

Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]

, 2007
BACKGROUND: Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high ...
A.R. Williams, Abramovitz, Benard, Bendvold, Billottet, Buchanan, Davidson, Ferrandina, Giavazzi, Gupta, H.N. Jabbour, Hwang, Jaaro, Jabbour, Jabbour, Jabbour, Jeremias, K.J. Sales, Kitamura, Lumsden, Luttrell, Milling, Narumiya, Pai, Pecorelli, Perchick, Pierce, Presta, R.A. Anderson, Regan, Robertson, S. Battersby, S. Gardner, Sales, Sales, Sales, Sales, Sales, Seger, Smalley, Smith, Taylor, Templeton, Tjandrawinata, Tong, Tsujii, Vane, Woodward, Yoshida   +48 more
core   +5 more sources