Results 31 to 40 of about 672,477 (393)

Fibroblast Growth Factor Receptor 2

Definitions, 2020
Fibroblast growth factor receptor 2 (821 aa, ~92 kDa) is encoded by the human FGFR2 gene. This protein plays a role in heparin-dependent fibroblast growth factor signaling.

semanticscholar   +1 more source

Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. [PDF]

, 2015
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival.
Helsten, Teresa, Kurzrock, Razelle, Schwaederle, Maria   +2 more
core   +2 more sources

Derazantinib Inhibits the Bioactivity of Keloid Fibroblasts via FGFR Signaling

Biomedicines, 2023
Keloids are common benign cutaneous pathological fibrous proliferation diseases, which are difficult to cure and easily recur. Studies have shown that fibroblast growth factor receptor-1 (FGFR1) was enhanced in pathological fibrous proliferation diseases,
Shuqia Xu, Yongkang Zhu, Peng Wang, Shaohai Qi, Bin Shu   +4 more
doaj   +1 more source

FGFR4 (fibroblast growth factor receptor 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Peer ...
Peláez-García, A, Barderas, R, Casal, JI   +2 more
openaire   +4 more sources

Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas [PDF]

, 2019
BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine kinases (RTKs) and members of the ...
Bergmann, C., Gires, O., Ihrler, S., Issing, W., Streit, S., Wimmer, E.   +5 more
core   +2 more sources

Hyperphosphatemic Tumoral Calcinosis With Pemigatinib Use

AACE Clinical Case Reports, 2022
Background/Objective: Pemigatinib, a fibroblast growth factor receptor (FGFR) 1-3 inhibitor, is a novel therapeutic approach for treating cholangiocarcinoma when an FGFR fusion or gene rearrangement is identified.
Akshan Puar, MBBS, Diane Donegan, MD, Paul Helft, MD, Matthew Kuhar, MD, Jonathan Webster, MD, Megana Rao, BS, Michael Econs, MD   +6 more
doaj  

Fibroblast growth factors as tissue repair and regeneration therapeutics [PDF]

PeerJ, 2016
Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or ...
Quentin M. Nunes, Yong Li, Changye Sun, Tarja K. Kinnunen, David G. Fernig   +4 more
doaj   +2 more sources

Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis

International Journal on Biological Sciences, 2017
Craniosynostosis results from the premature fusion of cranial sutures, with an incidence of 1 in 2,100-2,500 live births. The majority of cases are non-syndromic and involve single suture fusion, whereas syndromic cases often involve complex multiple ...
S. Azoury, Sashank K Reddy, V. Shukla, C. Deng   +3 more
semanticscholar   +1 more source

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis [PDF]

, 2008
INTRODUCTION: Despite the advent of biological therapies for the treatment of rheumatoid arthritis, there is a compelling need to develop alternative therapeutic targets for nonresponders to existing treatments. Soluble receptors occur naturally in vivo,
Brett Jorgensen, Damian Crawford, Ewa M Paleolog, H Michael Shepard, Irene Ni, Juan Zhang, Marc Feldmann, Pei Jin, Percy F Sumariwalla, Suzanne Phillips   +9 more
core   +3 more sources

The Role of Fibroblast Growth Factor Receptors Inhibitors in Bladder Cancer [PDF]

Journal of Urologic Oncology
Dysregulation of fibroblast growth factor (FGF)-receptor (FGFR) signaling, which is implicated in various oncogenic processes, including tumor proliferation, survival, migration, invasion, and angiogenesis, has been identified as a critical factor in ...
Ho Kyung Seo, Eui Hyun Jung, Sora Yang, Hye Won Lee   +3 more
doaj   +1 more source