Results 31 to 40 of about 367,714 (351)

Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer

Cells, 2018
Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis.
Navid Sobhani, Anna Ianza, Alberto D’Angelo, Giandomenico Roviello, Fabiola Giudici, Marina Bortul, Fabrizio Zanconati, Cristina Bottin, Daniele Generali   +8 more
doaj   +1 more source

Fibroblast Growth Factor 21 as a Marker of Prediabetes in Patients with Non-alcoholic Fatty Liver Disease

The Turkish Journal of Gastroenterology, 2022
Background: Fibroblast growth factor 21 is a peptide primarily secreted by the liver in response to peroxisome proliferator-activated receptor-α activation which plays an important role in regulating carbohydrate and lipid metabolism.
Vera Karamfilova, Yavor Assyov, Iveta Nedeva, Antoaneta Gateva, Irena Ivanova, Nikolay Cherkezov, Ludmila Mateva, Zdravko Kamenov   +7 more
doaj   +1 more source

Targeting fibroblast growth factor receptor (FGFR) pathway in renal cell carcinoma [PDF]

, 2015
Fibroblast growth factor receptor (FGFR) pathway is involved in driving vascular endothelial growth factor (VEGF)-independent tumor angiogenesis, as a compensatory mechanism to escape VEGF-targeted therapies.
Cheng, Liang, Ciccarese, Chiara, Lopez-Beltran, Antonio, Massari, Francesco, Montironi, Rodolfo, Santoni, Matteo, Scarpelli, Marina   +6 more
core   +1 more source

The Role of Fibroblast Growth Factor Receptors Inhibitors in Bladder Cancer [PDF]

Journal of Urologic Oncology
Dysregulation of fibroblast growth factor (FGF)-receptor (FGFR) signaling, which is implicated in various oncogenic processes, including tumor proliferation, survival, migration, invasion, and angiogenesis, has been identified as a critical factor in ...
Ho Kyung Seo, Eui Hyun Jung, Sora Yang, Hye Won Lee   +3 more
doaj   +1 more source

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]

, 2011
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson, Beenken, Bochukova, Burgar, Celli, Cohen, De Moerlooze, Duan, Duchesne, Ezzat, Fairbanks, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hanneken, Ibrahimi, Jang, Jang, Jang, John K. Heath, Jones, Kawano, Klein, Kuro-o, Lee M. Wheldon, Lewis, Maquat, McKeehan, Mendell, Meyers, Miki, Mohammad K. Hajihosseini, Muhlemann, Naila Khodabukus, Naski, Nelson, Oldridge, Peters, Polanska, Ricol, Saito, Sekine, Slaney, Smith, Susannah J. Patey, Takaishi, Tanimoto, Terada, Terence G. Smith, Tsang, Tsukuno, Werner, Wheldon, Wilkie, Yamaguchi, Zhang   +57 more
core   +3 more sources

Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion [PDF]

Yixue xinzhi zazhi
Objective To investigate the causal relationship between fibroblast growth factors (FGFs), their receptors (FGFRs) and spontaneous abortion (SA). Methods FGFs, FGFRs, and SA related GWAS data were obtained from the FinnGen Alliance and Genome-wide ...
LI Jing, SUN Caixuan, LI Ao, XUE Yilu, WANG Runlin, TANG Yuyun, CAO Yuanyuan   +6 more
doaj   +1 more source

Derazantinib Inhibits the Bioactivity of Keloid Fibroblasts via FGFR Signaling

Biomedicines, 2023
Keloids are common benign cutaneous pathological fibrous proliferation diseases, which are difficult to cure and easily recur. Studies have shown that fibroblast growth factor receptor-1 (FGFR1) was enhanced in pathological fibrous proliferation diseases,
Shuqia Xu, Yongkang Zhu, Peng Wang, Shaohai Qi, Bin Shu   +4 more
doaj   +1 more source

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V., Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +2 more
core   +2 more sources

FGFR (fibroblast growth factor receptor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008
Review on FGFR3 (fibroblast growth factor receptor 3), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources

Mechanism of Fibroblast Growth Factor in Alzheimer's Disease

Xiehe Yixue Zazhi
Alzheimer's disease(AD), the most common neurodegenerative disease, has shown an increasing incidence among younger people. With the onset of disease, most patients' cognitive function will show a progressive decline, bringing a heavy burden to the ...
WU Jiajing, LI Yan, LIANG Yuxia, HUA Huijuan, ZHAO Bo   +4 more
doaj   +1 more source