Results 51 to 60 of about 86,137 (348)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Detection of Fibronectin-Binding Proteins in Clostridium perfringens. [PDF]

, 2006
Clostridium perfringens is an anaerobic spore-forming pathogen of humans and animals. C. perfringens type A strains, 13, CPN50, and NCTC8237, isolated from human gas gangrene, bound specifically to human fi bronectin (Fn).
Hitsumoto, Yasuo, Katayama, Seiichi, Nozu, Nanami, Yokoyama, Masako   +3 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The evolution of metazoan extracellular matrix [PDF]

, 2011
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins.
Adams, Aouacheria, Ball, Barros, Bentley, Bergmeier, Boute, Chapman, Chiquet-Ehrismann, Couchman, Dehal, Engel, Ewan, Exposito, Exposito, Fahey, Gazave, Heino, Hohenester, Huhtala, Hutter, Huxley-Jones, Hynes, Hynes, Hynes, Hynes, King, King, Knack, Martindale, Merline, Myllyharju, Naba, Ozbek, Patthy, Philippe, Philippe, Pick, Putnam, Putnam, Ricard-Blum, Richard O. Hynes, Robertson, Sadler, Schaefer, Schierwater, Sebé-Pedrós, Shalchian-Tabrizi, Srivastava, Srivastava, Tucker, Wada, Whittaker, Whittaker, Yurchenco, Zhang   +55 more
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Triglycerides Predict Plasma Fibronectin in Children with Type I Diabetes Mellitus Rather than Diabetes

Acta Medica, 2002
Fibronectins are adhesive proteins considered as markers of endothelial activation. Plasma fibronectin levels in diabetes mellitus (DM) have been found to be associated with atherosclerotic risk factors.
Ayşe Binnur Erbağcı, Mehmet Tarakçıoğlu, Ahmet Erbağcı, Mehmet Gözübüyük, Necat Yılmaz, Rukiye Deveci, Ramazan Kocabaş   +6 more
doaj   +1 more source

Fibronectin and Fibronectin Receptors in Lung Development

Experimental Lung Research, 1997
Fibronectin (FN) is a cell adhesive extracellular matrix protein highly expressed in developing lungs. Although the role of FN in lung development remains to be elucidated, several observations suggest that it plays important roles in many developmental processes. In vitro, FN can affect the migration, proliferation, differentiation, and even apoptosis
openaire   +2 more sources

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Clostridial spores for cancer therapy : targeting solid tumour microenvironment [PDF]

, 2012
Solid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours.
Anne, Jozef, Duan, Wei, Good, David, Umer, Brittany, Wei, Ming Q.   +4 more
core   +3 more sources

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source