Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates. [PDF]
PLoS ONE, 2011 The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj +5 more
doaj +7 more sources
Association of ficolin-3 with severity and outcome of chronic heart failure. [PDF]
PLoS ONE, 2013 BACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin
Zoltán Prohászka +17 more
doaj +10 more sources
Increased expression of ficolin-1 is associated with airway obstruction in asthma [PDF]
BMC Pulmonary Medicine, 2023 Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao +8 more
doaj +2 more sources
Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus. [PDF]
PLoS ONE, 2016 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance
Maëlle Plawecki +14 more
doaj +7 more sources
Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]
Journal of Translational MedicineBackground Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao +7 more
doaj +2 more sources
Ficolin-3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the RIPK1/RIPK3/MLKL Signaling Pathway. [PDF]
FASEB JFCN3‐mediated activation of the lectin complement pathway via MASP2 binding induces necroptosis in cholangiocarcinoma cells through the RIPK1/RIPK3/MLKL axis. ABSTRACT Ficolin 3 (FCN3) is a pattern recognition molecule that activates the complement system via the lectin pathway.
Zhang Z +8 more
europepmc +2 more sources
The interaction pattern of murine serum ficolin-A with microorganisms. [PDF]
PLoS ONE, 2012 The ficolins are soluble pattern recognition molecules in the lectin pathway of complement, but the spectrum and mode of interaction with pathogens are largely unknown.
Tina Hummelshøj +9 more
doaj +4 more sources
Ficolin-2 amplifies inflammation in macrophage-smooth muscle cell cross-talk and increases monocyte transmigration by mechanisms involving IL-1β and IL-6 [PDF]
Scientific Reports, 2023 Ficolin-2, recently identified in atherosclerotic plaques, has been correlated with future acute cardiovascular events, but its role remains unknown. We hypothesize that it could influence plaque vulnerability by interfering in the cross-talk between ...
Răzvan Daniel Macarie +5 more
doaj +2 more sources
Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease [PDF]
BMC Research NotesObjective Ficolin-3 is a crucial protein for the activation of the complement system. Previous work has indicated this protein may play a role in the pathogenesis of rheumatic heart disease (RHD), and it has been hypothesised that ficolin-3 has potential
Zahra Parker +5 more
doaj +2 more sources
Association between serum ficolin-1 level and disease progression in primary biliary cholangitis.
PLoS ONE, 2020 Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown.
Manabu Hayashi +5 more
doaj +4 more sources