Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [PDF]
Infection and ImmunityPlasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome.
Di Zheng +15 more
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Increased expression of ficolin-1 is associated with airway obstruction in asthma [PDF]
BMC Pulmonary Medicine, 2023 Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao +8 more
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Ficolin-2 amplifies inflammation in macrophage-smooth muscle cell cross-talk and increases monocyte transmigration by mechanisms involving IL-1β and IL-6 [PDF]
Scientific Reports, 2023 Ficolin-2, recently identified in atherosclerotic plaques, has been correlated with future acute cardiovascular events, but its role remains unknown. We hypothesize that it could influence plaque vulnerability by interfering in the cross-talk between ...
Răzvan Daniel Macarie +5 more
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Diagnostic Value of Serum Ficolin-3 and Gal-3 in Sepsis Complicated with Acute Kidney Injury [PDF]
International Journal of General MedicineHang Yi,1 Ruiping Ye,2 Jinfeng Wang,3 Lin Gao,4 Weiwei Zhang,4 Chao Liu4 1Department of Intensive Care Medicine, Qianjiang Central Hospital, Qianjiang City, Hubei Province, 433100, People’s Republic of China; 2Department of Intensive Care Medicine, The ...
Yi H +5 more
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PLoS ONE, 2018 Among 98 serotypes of Streptococcus pneumoniae, only a small subset regularly causes invasive pneumococcal diseases (IPD). We previously demonstrated that serotype 11A binds to ficolin-2 and has low invasiveness in children. Epidemiologic data suggested,
K Aaron Geno +3 more
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Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C [PDF]
PeerJ, 2016 Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation.
Kimball Aaron Geno +4 more
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Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]
Journal of Translational MedicineBackground Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao +7 more
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Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India [PDF]
Scientific ReportsThe lectin pathway of complement aids in removing apoptotic cells and maintenance of tissue homeostasis. However, its role in SLE pathogenesis remains unknown.
Kirti Rai +11 more
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Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease [PDF]
BMC Research NotesObjective Ficolin-3 is a crucial protein for the activation of the complement system. Previous work has indicated this protein may play a role in the pathogenesis of rheumatic heart disease (RHD), and it has been hypothesised that ficolin-3 has potential
Zahra Parker +5 more
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Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1 [PDF]
Cell Communication and SignalingBackground Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the local microenvironment.
Li-Wen Zhu +8 more
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