Results 31 to 40 of about 7,998 (276)
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Diagnostic and prognostic value of H-ficolin for functionally relevant coronary artery disease
Clinica chimica acta; international journal of clinical chemistry, 2023 Ganna Isayeva +14 more
openalex +2 more sources
The Genetics of Ficolins [PDF]
Journal of Innate Immunity, 2009 Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the complement system.
Garred, Peter +6 more
openaire +4 more sources
International Journal of Medical Sciences, 2023 Background: Ficolin-3 (FCN3) is a well-known circulating pattern recognition molecule which plays a role in host immune responses to cancer via activation of the lectin complement pathway.
Chia-Chi Chen +9 more
semanticscholar +1 more source
Human L-Ficolin (Ficolin-2) and Its Clinical Significance [PDF]
Journal of Biomedicine and Biotechnology, 2012 Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this
Kilpatrick, David C., Chalmers, James D.
openaire +4 more sources
Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis
Autoimmunity, 2020 Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns, apoptotic cells, and cellular debris mediating the clearance by phagocytes.
Cristhine Pieczarka +7 more
openaire +3 more sources
Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours [PDF]
Cancer Immunology, Immunotherapy, 2013 Ficolins are serum pattern recognition molecules. They have opsonic properties and are able to activate complement via the lectin pathway. This paper reports investigations concerning ficolin-2 and ficolin-3 in ovarian cancer (OC). Their serum levels, single nucleotide polymorphisms of the corresponding FCN2 and FCN3 genes and specific mRNA expression ...
Agnieszka Szala +13 more
openaire +3 more sources
L-ficolin and H-ficolin in patients with Familial Mediterranean fever [PDF]
Pediatric Rheumatology, 2015 In the present study we performed comparative determination of the blood levels of L-ficolin and H-ficolin, opsonins and the initial components of the complement lectin pathway, in patients with Familial Mediterranean fever (FMF) in attack and attack-free periods and healthy subjects.
G Mkrtchyan, A Boyajyan
openaire +2 more sources
A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins. [PDF]
PLoS ONE, 2016 Despite recombinant protein technology development, proteins isolated from natural sources remain important for structure and activity determination. Ficolins represent a class of proteins that are difficult to isolate.
Aleksandra Man-Kupisinska +6 more
doaj +1 more source