Results 31 to 40 of about 5,314 (149)

Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil

Frontiers in Immunology, 2018
The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens ...
Maria Regina Tizzot, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Hellen Weinschutz Mendes, Marcia Holsbach Beltrame, Edna Reiche, Steffen Thiel, Jens C. Jensenius, Iara J. de Messias-Reason   +8 more
doaj   +1 more source

Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors

Frontiers in Immunology, 2021
Thousands of leprosy patients not only suffer from physical deformities, but also either have or have had hepatitis B virus (HBV) coinfection. Polymorphisms of the complement system modulate susceptibility to leprosy, but genetic susceptibility to past ...
Angelica Beate Winter Boldt, Angelica Beate Winter Boldt, Camila de Freitas Oliveira-Toré, Gabriela Canalli Kretzschmar, Hellen Weinschutz Mendes, Sérvio Túlio Stinghen, Fabiana Antunes Andrade, Valéria Bumiller-Bini, Letícia Boslooper Gonçalves, Anna Carolina de Moraes Braga, Ewalda von Rosen Seeling Stahlke, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Steffen Thiel, Iara José Taborda de Messias-Reason   +15 more
doaj   +1 more source

Local and Systemic Concentrations of Pattern Recognition Receptors of the Lectin Pathway of Complement in a Cohort of Patients With Interstitial Lung Diseases

Frontiers in Immunology, 2020
BackgroundThe role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via ...
Severin Vogt, Severin Vogt, Marten Trendelenburg, Marten Trendelenburg, Marten Trendelenburg, Michael Tamm, Michael Tamm, Daiana Stolz, Daiana Stolz, Katrin Esther Hostettler, Katrin Esther Hostettler, Michael Osthoff, Michael Osthoff, Michael Osthoff   +13 more
doaj   +1 more source

Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy. [PDF]

PLoS Neglected Tropical Diseases, 2017
Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nervous system, leading to a high disability rate and social stigma.
Fabiana Antunes Andrade, Marcia Holsbach Beltrame, Valéria Bumiller Bini, Letícia Boslooper Gonçalves, Angelica Beate Winter Boldt, Iara Jose de Messias-Reason   +5 more
doaj   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin.

PLoS ONE, 2012
BackgroundThe innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells.
Christian Gytz Ammitzbøll, Troels Rønn Kjær, Rudi Steffensen, Kristian Stengaard-Pedersen, Hans Jørgen Nielsen, Steffen Thiel, Martin Bøgsted, Jens Christian Jensenius   +7 more
doaj   +1 more source

Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients. [PDF]

PLoS ONE, 2013
BACKGROUND: In HIV-infected patients, prediction of Cytomegalovirus (CMV) disease remains difficult. A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected
Adrian Egli, Juliane Schäfer, Michael Osthoff, Steffen Thiel, Christina Mikkelsen, Andri Rauch, Hans H Hirsch, Heiner C Bucher, James Young, Jens C Jensenius, Manuel Battegay, Marten Trendelenburg, Swiss HIV Cohort Study   +12 more
doaj   +1 more source

Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease

Frontiers in Immunology, 2022
Reports conflict regarding which lectin-microbial ligand interactions elicit a protective response from the lectin pathway (LP) of complement. Using fluorescent microscopy, we demonstrate the human lectin ficolin-2 binds to Streptococcus pneumoniae ...
Moon H. Nahm, Jigui Yu, Juan J. Calix, Juan J. Calix, Feroze Ganaie   +4 more
doaj   +1 more source

Sinapine Modulates Glycogen and Lipid Synthesis via IRS1–PI3K–AKT–GSK3β–GS Pathway in Insulin‐Resistant Models

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study combined network pharmacology, molecular docking, and in vitro (HepG2) and in vivo (T2DM mice) experiments to investigate sinapine's effect on insulin resistance. Sinapine was found to modulate the IRS1–PI3K–AKT–GSK3β–GS pathway. In vitro, sinapine improved glucose uptake, enhanced glycogen synthesis, and reduced lipogenesis and ROS. In vivo,
Tiancheng Xing, Yiling Bai, Weijie Wu, Ziqi Zhao, Hanyu Kong, Qianyi Zhang, Shuoqi Li, Yan Liu, Xiaohui Guo, Zengli Wang   +9 more
wiley   +1 more source

A Comparison of Emotionally Stimulated and Conventionally Collected Tears Using Bottom‐Up, Label‐Free Quantitative Proteomic Analysis—A Pilot Study

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Proteomic analysis of biofluids is central for identifying disease biomarkers. Tears have become popular targets for biomarker discovery and biosensor development, largely because they can be collected noninvasively and are rich sources of biomarkers for ocular and systemic diseases. Although basal and reflex tears have been well characterized,
Campbell Bruce Mousseau, Alena R. Veigl‐Lunsford, Rhonda L. Pitsch, Sean W. Harshman   +3 more
wiley   +1 more source