Results 51 to 60 of about 5,314 (149)

Screening for immune-potentiating antigens from hepatocellular carcinoma patients after radiofrequency ablation by serum proteomic analysis

BMC Cancer, 2018
Background Radiofrequency ablation (RFA) can not only effectively kill hepatocellular carcinoma (HCC) tumour cells but also release tumour antigens that can provoke an immune response.
Shunli Shen, Hong Peng, Ye Wang, Ming Xu, Manxia Lin, Xiaoyan Xie, Baogang Peng, Ming Kuang   +7 more
doaj   +1 more source

The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes

Scientific Reports, 2021
H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes ...
Jakob Appel Østergaard, Fanny Jansson Sigfrids, Carol Forsblom, Emma H. Dahlström, Lena M. Thorn, Valma Harjutsalo, Allan Flyvbjerg, Steffen Thiel, Troels Krarup Hansen, Per-Henrik Groop   +9 more
doaj   +1 more source

Enrichment of Immune Cell‐Derived Extracellular Vesicles From Plasma Using 35 and 70 nm Size‐Exclusion Chromatography Columns of Different Sizes

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Extracellular vesicles (EVs) from blood plasma are promising biomarkers, as they carry surface markers indicative of their cell of origin. Size‐exclusion chromatography (SEC) is commonly employed for EV enrichment, but the choice of pore size and plasma volume can significantly impact the yield, purity, and composition of isolated EVs. In this
Iris Potakowskyj, Ivan Bagarić, Nevena Prodanović, Adrián Parrilla Mesas, Olga Glatki, Klaus Heukamp, Kenneth W. Witwer, Hanns‐Martin Lorenz, Lars‐Oliver Tykocinski, Aoife Ward Gahlawat, Gorjana Rackov   +10 more
wiley   +1 more source

Revisiting Glomerulopathy in Clusterin Knockout Mice: A Mouse Model of Human Immunotactoid Glomerulopathy

Nephrology, Volume 30, Issue 11, November 2025.
Key findings: This study confirmed that the glomerulopathy in CLU‐KO B6 mice was similar to the pathological features of ITG and may be therefore considered as an experimental model of ITG. Further, CLU may negatively regulate the fibrillogenesis of ITG.
Xinglan Li, Xingwei Cai, Qiunong Guan, Junya Tan, Xudan Yang, Changhong Wu, Caigan Du   +6 more
wiley   +1 more source

Human Lectins and Their Roles in Viral Infections

Molecules, 2015
Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that recognise viral pathogen-associated ...
Christopher P. Mason, Alexander W. Tarr
doaj   +1 more source

The clinical value of ficolin-3 gene polymorphism in rheumatic heart disease. An Egyptian adolescents study

BMC Research Notes, 2021
Objective Ficolin-3 is one of the innate immunity molecules that was thought to play a pivotal role in Streptococcus pyogenes autoimmunity and its complications; rheumatic fever (RF) and rheumatic heart disease (RHD).
Maher H. Gomaa, Emad Gamil Khidr, Ahmed Elshafei, Hala S. Hamza, Aya M. Fattouh, Ahmed A. El-Husseiny, Ahmed Aglan, Mahmoud Gomaa Eldeib   +7 more
doaj   +1 more source

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra, Kai Yu, Jason Rogalski, Taylor Olivia Da Silva, Parisa Golesorkhi, Madeleine Goldstein, Dana V. Devine, Jayachandran N. Kizhakkedathu   +7 more
wiley   +1 more source

Pan‐cancer analysis and oncogenic implications of MGAM and MGAM2: Toward precision oncology and drug repurposing in colorectal cancer

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
Abstract Cancer remains a major global health challenge, with high prevalence and mortality rates emphasizing the urgent need for innovative treatment strategies. Although precision oncology offers tailored therapies based on genetic profiles, the clinical translation of genomic insights has been slow.
Rawaa Chasib Mezher, Hanieh Azari, Reza Khayami, Hamid Fiuji, Farzaneh Alizadeh, Ladan Goshayeshi, Majid Rajabian, Ibrahim Saeed Gataa, Seyed Mahdi Hassanian, Amir Avan   +9 more
wiley   +1 more source

Association of L-ficolin levels and FCN2 genotypes with chronic Chagas disease.

PLoS ONE, 2013
BackgroundL-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the complement system.MethodsWe investigated L-ficolin levels in 160 T.
Paola R Luz, Angelica B W Boldt, Caroline Grisbach, Jürgen F J Kun, Thirumalaisamy P Velavan, Iara J T Messias-Reason   +5 more
doaj   +1 more source

The Etiopathogenesis of Kawasaki Disease: Evolving Understanding of Diverse Triggers

Immunity, Inflammation and Disease, Volume 13, Issue 9, September 2025.
ABSTRACT Background Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Evidence suggests that microbial and nonmicrobial triggers for KD differ across geographical regions and environmental conditions. Although the precise triggers remain unidentified, KD is likely caused by microbial or environmental agents acting on ...
Toshiro Hara, Yasunari Sakai
wiley   +1 more source