Results 51 to 60 of about 7,998 (276)

Ficolin-2: A potential immune-related therapeutic target with low expression in liver cancer

open access: yesFrontiers in Oncology, 2022
Objective This study aimed to investigate the role of ficolin-2 (FCN2) in the development and course of hepatocellular carcinoma (HCC) and to contribute to the evolution of innovative HCC therapeutics.
Li-ting Wang   +6 more
semanticscholar   +1 more source

Blood Collection Tubes Influence Serum Ficolin-1 and Ficolin-2 Levels [PDF]

open access: yesClinical and Vaccine Immunology, 2013
ABSTRACTThe ficolins are members of a recently discovered family of host innate opsonins that can activate the lectin pathway of complement. The ficolins bind many ligands, although they are typically described as binding acetylated sugars. Ficolin-1 (M-ficolin) and ficolin-2 (L-ficolin) are known to bindStreptococcus pneumoniaeserotypes 19C and 11A ...
Ann R. Falsey   +3 more
openaire   +3 more sources

Sequencing and analysis of the gastrula transcriptome of the brittle star Ophiocoma wendtii [PDF]

open access: yes, 2012
Background The gastrula stage represents the point in development at which the three primary germ layers diverge. At this point the gene regulatory networks that specify the germ layers are established and the genes that define the differentiated states ...
Garey, James R.   +4 more
core   +2 more sources

Ficolin‐3 and MASP‐2 gene variants in Siberian arctic populations: Summarized evidence of selective pressure for the high frequency of lectin complement pathway deficiency

open access: yesScandinavian Journal of Immunology, 2022
Herewith, we provide novel original data about the prevalence of FCN3 rs532781899 and MASP2 rs72550870 variants among the newborns of aboriginal Siberian Arctic populations (Nenets and Dolgan‐Nganasans) and Russians of East Siberia.
S. Tereshchenko   +2 more
semanticscholar   +1 more source

Expansion of Fcγ Receptor IIIa–Positive Macrophages, Ficolin 1–Positive Monocyte‐Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis

open access: yesArthritis & Rheumatology, 2021
In this study, we sought a comprehensive understanding of myeloid cell types driving fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) skin.
D. Xue   +6 more
semanticscholar   +1 more source

Ficolins and infectious diseases

open access: yesVirologica Sinica, 2014
Ficolins are serum complement lectins, with a structure similar to mannose-binding lectin (MBL) and lung surfactant protein (SP)-A and SP-D. Ficolins activate the lectin complement system and play important roles in host innate immunity. Ficolins are members of the collectin family of proteins, which act as pattern recognition receptors (PRRs).
Quanquan Ding   +2 more
openaire   +4 more sources

Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge. [PDF]

open access: yes, 2015
Invasive aspergillosis is a devastating invasive fungal disease associated with a high mortality rate in the immunocompromised, such as leukaemia patients, transplant patients and those with HIV/AIDS.
Bidula, S, Schelenz, S, Sexton, DW
core   +1 more source

Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia

open access: yesClinical and Experimental Immunology, 2012
Summary Ficolins are soluble molecules of the innate immune system that recognize carbohydrate molecules on microbial pathogens, apoptotic and necrotic cells. They act through two distinct routes: initiating the lectin pathway of complement activation and mediating a primitive opsonophagocytosis.
György Füst   +6 more
openaire   +4 more sources

Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. [PDF]

open access: yes, 2015
Reliable, non-invasive methods for diagnosing and prognosing sinusoidal obstruction syndrome (SOS) early after hematopoietic cell transplantation (HCT) are needed.
Akil, Ayman   +14 more
core   +1 more source

Ficolin A exacerbates severe H1N1 influenza virus infection-induced acute lung immunopathological injury via excessive complement activation

open access: yesCellular & Molecular Immunology, 2021
Severe pandemic influenza A (H1N1) 2009 virus (pH1N1) infection causes significant morbidity and mortality. We and other groups have reported that immunopathological damage induced by excessive pulmonary inflammation plays a critical role in the ...
Xu Wu   +10 more
semanticscholar   +1 more source

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