Results 11 to 20 of about 3,672 (125)

Filoviridae: Insights into Immune Responses to Ebolavirus

SSRN Electronic Journal, 2023
Ebola virus is a zoonotic virus comprised of 6 different species designated within the family Filoviridae and genus Ebolavirus. The first recorded outbreak of an Ebola virus (EBOV) was in Yambuku, Zaire (ZEBOV) in 1976, followed by Sudan Ebola virus (SUBOV) later that year. Outbreaks have been increasing throughout the 21st century, and mortality rates
Brent Brown, Chinua Imarogbe, Tanya Gravier, Ingo Fricke, Tereena Lucas   +4 more
openaire   +2 more sources

ICTV Virus Taxonomy Profile: Filoviridae 2024. [PDF]

J Gen Virol
Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1-20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and
Biedenkopf N, Bukreyev A, Chandran K, Di Paola N, Formenty PBH, Griffiths A, Hume AJ, Mühlberger E, Netesov SV, Palacios G, Pawęska JT, Smither S, Takada A, Wahl V, Kuhn JH.   +14 more
europepmc   +3 more sources

Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations

Problems of Virology, 2021
Ebola virus disease (EVD) (former Ebola hemorrhagic fever) is one of the most dangerous infectious diseases affecting humans and primates. Since the identification of the first outbreak in 1976, there have been more than 25 outbreaks worldwide, the largest of which escalated into an epidemic in 2014-2016 and caused the death of more than 11,000 people.
I. V. Dolzhikova, D. N. Shcherbinin, D. Yu. Logunov, A. L. Gintsburg   +3 more
openaire   +5 more sources

Viruses of the Filoviridae family

Science and Innovations, 2023
The article considers representatives of the Filoviridae family, some of which are the causative agents of hemorrhagic fever, which is fatal to humans. The current state of development of immunobiological drugs for the treatment and medical prevention of diseases caused by filoviruses has been analyzed.
A. Chernykh, A. Hancharou
openaire   +1 more source

Analysis of Simple and Imperfect Microsatellites in Ebolavirus Species and Other Genomes of Filoviridae Family [PDF]

Gene, Cell and Tissue, 2015
Background: Microsatellites have evoked the interest of researchers owing to their applications in different fields such as DNA fingerprinting, genetic mapping, population genetics, forensics, paternity studies and evolution. Objectives: The present study focused on the analysis of simple sequence repeats (SSRs) in genomes of seven species from three ...
Chaudhary Mashhood Alam, Choudhary Sharfuddin, Safdar Ali   +2 more
openaire   +2 more sources

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Filoviridae: insights into immune responses to Ebola virus

Exploration of Immunology
Ebola virus (EBOV) is a zoonotic virus comprising of six known different species, designated within the family Filoviridae and genus Ebolavirus. The first recorded outbreak of an EBOV disease (EVD) was in Yambuku, Zaire EBOV (ZEBOV) in 1976, followed by the Sudan EBOV (SUDV) later that year.
Brent Brown, Chinua Imarogbe, Enrique Chacon-Cruz, Ingo Fricke   +3 more
openaire   +2 more sources

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

A public, cross‐reactive glycoprotein epitope confounds Ebola virus serology

Journal of Medical Virology, Volume 96, Issue 10, October 2024.
Abstract Ebola disease (EBOD) in humans is a severe disease caused by at least four related viruses in the genus Orthoebolavirus, most often by the eponymous Ebola virus. Due to human‐to‐human transmission and incomplete success in treating cases despite promising therapeutic development, EBOD is a high priority in public health research.
Markus H. Kainulainen, Jessica R. Harmon, Elif Karaaslan, Jackson Kyondo, Amy Whitesell, Sam Twongyeirwe, Jason H. Malenfant, Jimmy Baluku, Aaron Kofman, Éric Bergeron, Michelle A. Waltenburg, Luke Nyakarahuka, Stephen Balinandi, Caitlin M. Cossaboom, Mary J. Choi, Trevor R. Shoemaker, Joel M. Montgomery, Christina F. Spiropoulou   +17 more
wiley   +1 more source

A meta‐analysis exploring associations between habitat degradation and Neotropical bat virus prevalence and seroprevalence

Ecography, Volume 2024, Issue 10, October 2024.
Habitat degradation can increase zoonotic disease risks by altering infection dynamics in wildlife and increasing wildlife–human interactions. Bats are an important taxonomic group to consider these effects, because they harbour many relevant zoonotic viruses and have species‐ and context‐dependent responses to degradation that could affect zoonotic ...
Alexis M. Heckley, Lauren R. Lock, Daniel J. Becker   +2 more
wiley   +1 more source