Results 1 to 10 of about 9,370 (262)

Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids. [PDF]

Mar Drugs
Filoviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Wang LL, Seravalli J, Eaton B, Liu Y, Holbrook MR, Lan WJ, Xiang SH.   +6 more
europepmc   +4 more sources

Correlates of Immunity to Filovirus Infection [PDF]

Viruses, 2011
Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
Bavari, Sina, Bradfute, Steven B.
core   +7 more sources

New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs. [PDF]

Front Chem
Ebola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective ...
Tamilarasi W, Balamurugan BJ.
europepmc   +3 more sources

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]

eLife, 2015
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Agnarsson, Allison, Almeida, Amman, Amman, Baker, Biesold, Bolger, Carette, Carroll, Carstea, Chandran, Cui, Côté, Daugherty, Deffieu, Delport, Demogines, Demogines, Drexler, Ebihara, Feldmann, Ge, Gire, Grabherr, He, Herbert, Hueffer, Jahrling, Jangra, Jayme, Jones, Kaelber, Kamins, Katzourakis, Krishnan, Kugelman, Kuhn, Kühl, Lee, Leroy, Li, Mali, Maruyama, Meyerson, Miller, Miller, Miller-Butterworth, Murrell, Negredo, Ng, Olival, Park, Parker, Paweska, Peel, Pond, Radoshitzky, Radoshitzky, Raj, Ren, Robertson, Ross, Runz, Ruxton, Sheahan, Swenson, Swenson, Takada, Taylor, Taylor, Taylor, Tong, Towner, Vanier, Volchkov, Wahl-Jensen, Wong, Yang   +78 more
core   +4 more sources

Implementation of objective PASC-derived taxon demarcation criteria for official classification of filoviruses [PDF]

Viruses, 2017
The mononegaviral family Filoviridae has eight members assigned to three genera and seven species. Until now, genus and species demarcation were based on arbitrarily chosen filovirus genome sequence divergence values (≈50% for genera, ≈30% for species ...
Amarasinghe, Gaya K, et al,
core   +4 more sources

A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses. [PDF]

Microbiol Spectr
Filoviruses are some of the most lethal viruses in the modern world, and increasing numbers of filovirus species and genera have been discovered in recent years.
Cui N, Perez YL, Hume AJ, Nunley BE, Kong K, Mills MG, Xie H, Greninger AL.   +7 more
europepmc   +2 more sources

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]

Viruses, 2012
We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Chandran, Kartik, Dye, John M., Herbert, Andrew S., Krishnan, Anuja, Miller, Emily Happy, Ndungo, Esther, Ng, Melinda, Whelan, Sean P.J.   +7 more
core   +4 more sources

Recombinant Vesicular Stomatitis Virus Vaccine Vectors Expressing Filovirus Glycoproteins Lack Neurovirulence in Nonhuman Primates [PDF]

PLoS Neglected Tropical Diseases, 2012
The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (
A Bukreyev, A Roberts, A Roberts, AH Frank, AL Hartman, AN van den Pol, Andrew D. Miller, Angela Carville, B Schlereth, B Schlereth, BS Huneycutt, CE Mire, Chad E. Mire, CS Reiss, DA Hensley LE Alves, Daniel G. Bausch, DF Stojdl, DJ Wood, DL Swenson, DL Swenson, H Feldmann, Heinz Feldmann, HR Jayakar, IS Levenbook, IS Levenbuk, IV Plakhov, JA Brody, JD Reuter, JE Johnson, JG Fournier, JH Sur, Joan B. Geisbert, JS Kahn, JS Towner, K Miyoshi, K Yamanouchi, Keith G. Mansfield, KL Warfield, KM Daddario-DiCaprio, KM Daddario-DiCaprio, KM Johnson, LE Hensley, Lisa E. Hensley, M Garbutt, M Hevey, M Mehedi, MA Egan, N Nathanson, ND Lawson, NF Rose, NF Rose, NJ Sullivan, NJ Sullivan, NJ Sullivan, O Maximova, OK Sharova, PK Olitsky, PN Fultz, RS Marchevsky, S Gunther, SA Rubin, SM Jones, SM Jones, SU Kapadia, Susan V. Westmoreland, Thomas W. Geisbert, TW Geisbert, TW Geisbert, TW Geisbert, TW Geisbert, TW Geisbert, TW Geisbert, TW Geisbert, WD Pratt, X Qiu, Z Bi   +75 more
core   +11 more sources

Marburg Virus Disease: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A, Fakhr SSH, Najafabadi AQ, Karami N, Karami H.   +4 more
europepmc   +2 more sources

Peripheral immune responses to filoviruses in a reservoir versus spillover hosts reveal transcriptional correlates of disease. [PDF]

Front Immunol, 2023
Several filoviruses, including Marburg virus (MARV), cause severe disease in humans and nonhuman primates (NHPs). However, the Egyptian rousette bat (ERB, Rousettus aegyptiacus), the only known MARV reservoir, shows no overt illness upon natural or ...
Guito JC, Arnold CE, Schuh AJ, Amman BR, Sealy TK, Spengler JR, Harmon JR, Coleman-McCray JD, Sanchez-Lockhart M, Palacios GF, Towner JS, Prescott JB.   +11 more
europepmc   +2 more sources