Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids [PDF]
Marine DrugsFiloviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang +6 more
doaj +3 more sources
New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs [PDF]
Frontiers in ChemistryEbola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective ...
W. Tamilarasi, B. J. Balamurugan
doaj +3 more sources
Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids. [PDF]
PLoS PathogGastrointestinal (GI) dysfunction, characterized by severe diarrhea and dehydration, is a central contributor to morbidity and mortality in filovirus disease in patients, yet the role of the epithelium in this clinical outcome remains poorly defined ...
Flores EY +12 more
europepmc +2 more sources
One-for-one or one-for-all? Considerations for filovirus vaccine development. [PDF]
PLoS BiolFiloviruses continue to re-emerge in Africa, causing localized public health emergencies. Although vaccination has slowly been implemented for Ebola virus, not for other filoviruses, holistic approaches are needed to broadly protect against filovirus ...
Marzi A.
europepmc +2 more sources
Antiviral defense against filovirus infections: targets and evasion mechanisms. [PDF]
Future MicrobiolFiloviruses include a number of serious human pathogens, infections with which result in the development of hemorrhagic fevers with high case fatality rates.
Bodmer BS +4 more
europepmc +2 more sources
Filovirus vaccines as a response paradigm for emerging infectious diseases. [PDF]
NPJ VaccinesNowadays, filovirus vaccine development may be seen as a paradigm for our response capabilities to emerging and re-emerging infectious diseases. Specifically, the West African Ebola virus disease (EVD) epidemic accelerated countermeasure licensure for ...
Marzi A, Feldmann H.
europepmc +2 more sources
Vaccines, 2022 Since the discovery of the Marburg virus (MARV) in 1967 and Ebola virus (EBOV) in 1976, there have been over 40 reported outbreaks of filovirus disease with case fatality rates greater than 50%.
Thomas L. Rudge +7 more
doaj +2 more sources
Marburg and Sudan virus outbreaks: are we any closer to a pan-filovirus vaccine? [PDF]
Tropical Diseases, Travel Medicine and VaccinesFiloviruses, including Ebola, Marburg, and Sudan viruses, cause severe hemorrhagic fevers with high mortality rates and outbreaks. While recent vaccine developments such as the rVSV-ZEBOV vaccine for Ebola have marked important progress and is now ...
Adewunmi Akingbola +6 more
doaj +2 more sources
Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification [PDF]
Nature CommunicationsFiloviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee +13 more
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Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress [PDF]
VirusesFiloviruses, including Ebola (EBOV) and Marburg (MARV) viruses, are zoonotic pathogens that cause severe hemorrhagic fever in humans, with mortality rates reaching up to 90%.
Loveleena K. Anand +4 more
doaj +2 more sources