Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids [PDF]
Marine DrugsFiloviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang +6 more
doaj +5 more sources
Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids. [PDF]
PLoS PathogGastrointestinal (GI) dysfunction, characterized by severe diarrhea and dehydration, is a central contributor to morbidity and mortality in filovirus disease in patients, yet the role of the epithelium in this clinical outcome remains poorly defined ...
Flores EY +12 more
europepmc +3 more sources
Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification [PDF]
Nature CommunicationsFiloviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee +13 more
doaj +3 more sources
One-for-one or one-for-all? Considerations for filovirus vaccine development. [PDF]
PLoS BiolFiloviruses continue to re-emerge in Africa, causing localized public health emergencies. Although vaccination has slowly been implemented for Ebola virus, not for other filoviruses, holistic approaches are needed to broadly protect against filovirus ...
Marzi A.
europepmc +3 more sources
New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs [PDF]
Frontiers in ChemistryEbola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective ...
W. Tamilarasi, B. J. Balamurugan
doaj +3 more sources
Filovirus tropism: Cellular molecules for viral entry [PDF]
Frontiers in Microbiology, 2012 In human and nonhuman primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever．Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference
Ayato eTakada
doaj +2 more sources
Direct Intercellular Transport Mode of Filovirus Nucleocapsids. [PDF]
Int J Mol SciIntercellular pathways of viral infection in host cells offer advantages, such as efficiency of viral spread and immune surveillance evasion, compared to cell-free viral infection. Therefore, some enveloped viruses present both cell-to-cell and cell-free
Ibrahim CHO, Takamatsu Y.
europepmc +2 more sources
Filovirus vaccines as a response paradigm for emerging infectious diseases. [PDF]
NPJ VaccinesNowadays, filovirus vaccine development may be seen as a paradigm for our response capabilities to emerging and re-emerging infectious diseases. Specifically, the West African Ebola virus disease (EVD) epidemic accelerated countermeasure licensure for ...
Marzi A, Feldmann H.
europepmc +2 more sources
Conserved Filovirus Proteins as Targets of Broad-Spectrum Antivirals [PDF]
bioRxivFiloviruses are enveloped, non-segmented, negative-strand RNA viruses belonging to the Filoviridae family, which includes five genera: Ebolavirus, Marburgvirus, Cuevavirus, Striavirus, and Thamnovirus.
Marcus Tullius Scotti +8 more
openalex +2 more sources
Infection prevention and control studies for care of patients with suspected or confirmed filovirus disease in healthcare settings, with focus on Ebola and Marburg: an integrative review [PDF]
BMJ public healthObjective To review evidence pertaining to methods for preventing healthcare-associated filovirus infections (including the survivability of filoviruses in clinical environments and the chlorine concentration required for effective disinfection), and to ...
Raphael Frankfurter +5 more
openalex +2 more sources