Results 161 to 170 of about 6,852 (197)
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Virus Research, 2004
Family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), is a growing threat to human and non-human primate populations in central Africa. Although many facets of the filovirus life cycle remain to be deciphered, a great deal has been learned in recent years. In particular, a clearer understanding of the roles played by viral, as
Luke D, Jasenosky, Yoshihiro, Kawaoka
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Family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), is a growing threat to human and non-human primate populations in central Africa. Although many facets of the filovirus life cycle remain to be deciphered, a great deal has been learned in recent years. In particular, a clearer understanding of the roles played by viral, as
Luke D, Jasenosky, Yoshihiro, Kawaoka
openaire +2 more sources
Journal of Infectious Diseases, 2023
BACKGROUND The family Filoviridae consists of several virus members known to cause significant mortality and disease in humans. Among these, Ebola virus (EBOV), Marburg virus (MARV), Sudan virus (SUDV), and Bundibugyo virus (BDBV) are considered the ...
Courtney Woolsey +13 more
semanticscholar +1 more source
BACKGROUND The family Filoviridae consists of several virus members known to cause significant mortality and disease in humans. Among these, Ebola virus (EBOV), Marburg virus (MARV), Sudan virus (SUDV), and Bundibugyo virus (BDBV) are considered the ...
Courtney Woolsey +13 more
semanticscholar +1 more source
Filovirus Infection in Humanized Mouse Models.
Methods in molecular biologySince the discovery of filoviruses in 1967, there have been more than 40 outbreaks with high case-fatality rates causing more than 30,000 deaths in humans. Filovirus disease (FVD) involves the dysregulation of many host physiological processes. While many advances in the field have taken place since the first outbreaks, the dearth of small animal ...
E. Rodríguez +2 more
semanticscholar +3 more sources
Vaccine, 2023
Although two vaccines for Zaire ebolavirus (EBOV) have been licensed and deployed successfully to combat recurring outbreaks of Ebolavirus Disease in West Africa, there are no vaccines for two other highly pathogenic members of the Filoviridae, Sudan ...
Albert To +16 more
semanticscholar +1 more source
Although two vaccines for Zaire ebolavirus (EBOV) have been licensed and deployed successfully to combat recurring outbreaks of Ebolavirus Disease in West Africa, there are no vaccines for two other highly pathogenic members of the Filoviridae, Sudan ...
Albert To +16 more
semanticscholar +1 more source
2018
Filoviruses are highly filamentous enveloped animal viruses that can cause severe haemorrhagic fevers. The filovirus ribonucleoprotein forms a highly organized double-layered helical nucleocapsid (NC) containing five different virally encoded proteins. The inner layer consists of NP, the RNA binding protein, complexed with the monopartite linear genome.
Daniel R, Beniac +2 more
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Filoviruses are highly filamentous enveloped animal viruses that can cause severe haemorrhagic fevers. The filovirus ribonucleoprotein forms a highly organized double-layered helical nucleocapsid (NC) containing five different virally encoded proteins. The inner layer consists of NP, the RNA binding protein, complexed with the monopartite linear genome.
Daniel R, Beniac +2 more
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Production and Purification of Filovirus Glycoproteins.
Methods in molecular biologyEbola (EBOV) and Marburg (MARV) viruses cause hemorrhagic fever disease in humans and non-human primates (NHPs) with case-fatality rates as high as 90%. The 2013-2016 Ebola virus disease (EVD) outbreak led to over 28,000 cases and 11,000 deaths and took an enormous toll on the economy of West African nations, in the absence of any vaccine or ...
Madeleine Noonan-Shueh +2 more
semanticscholar +3 more sources
Polymorphism of Filovirus Glycoproteins
2005Publisher Summary Filoviral glycoproteins are encoded by gene 4 (GP gene) of the nonsegmented negative-strand RNA genome. Nonstructural glycoprotein (sGP) as well as Ebola virus (EBOV) and Marburgvirus (MBGV) GP undergo several posttranslational processing steps giving rise to a whole series of different glycoproteins.
Viktor E, Volchkov +4 more
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The Ferret as a Model for Filovirus Pathogenesis and Countermeasure Evaluation.
ILAR journal, 2021The domestic ferret (Mustela putorius furo) has long been a popular animal model for evaluating viral pathogenesis and transmission as well as the efficacy of candidate countermeasures.
Zachary Schiffman +6 more
semanticscholar +1 more source
2017
Filovirus entry into cells is complex, perhaps as complex as any viral entry mechanism identified to date. However, over the past 10 years, the important events required for filoviruses to enter into the endosomal compartment and fuse with vesicular membranes have been elucidated (Fig. 1).
R A, Davey +5 more
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Filovirus entry into cells is complex, perhaps as complex as any viral entry mechanism identified to date. However, over the past 10 years, the important events required for filoviruses to enter into the endosomal compartment and fuse with vesicular membranes have been elucidated (Fig. 1).
R A, Davey +5 more
openaire +2 more sources
[Haemostasis dysregulation in filovirus infections]
Medecine sciences : M/S, 2015(Uploaded by Plazi for the Bat Literature Project) Filoviruses are responsible for highly lethal infections. Those viruses are found in intertropical areas of Africa and Asia where they circulate in their supposed natural reservoir, fruit bats. During filovirus outbreaks and depending on the strains, various modifications in hemostasis have been ...
Olivier, Reynard +2 more
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