New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs [PDF]
Frontiers in ChemistryEbola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective ...
W. Tamilarasi, B. J. Balamurugan
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Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health. [PDF]
Microb BiotechnolBat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Brüssow H.
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Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses [PDF]
Nature CommunicationsThe Ebola and the Marburg viruses belong to the Filoviridae family, a group of filamentous, single-stranded, negative-sensed RNA viruses. Upon infection, uncontrolled propagation of the Ebola and the Marburg viruses causes severe hemorrhagic fevers with ...
Guobao Li +8 more
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One-for-one or one-for-all? Considerations for filovirus vaccine development. [PDF]
PLoS BiolMarzi A.
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Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
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Undiscovered Bat Hosts of Filoviruses. [PDF]
PLoS Neglected Tropical Diseases, 2016 Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high ...
Barbara A Han +5 more
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A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates. [PDF]
PLoS ONE, 2018 The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections.
Benoit Callendret +20 more
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Acta Pharmaceutica Sinica B, 2018 Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which
Qing Chen +4 more
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Vaccines, 2022 Since the discovery of the Marburg virus (MARV) in 1967 and Ebola virus (EBOV) in 1976, there have been over 40 reported outbreaks of filovirus disease with case fatality rates greater than 50%.
Thomas L. Rudge +7 more
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Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies
Viruses, 2019 Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication.
Md Niaz Rahim +8 more
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