Results 11 to 20 of about 6,852 (197)

A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses [PDF]

Microbiology Spectrum
Filoviruses are some of the most lethal viruses in the modern world, and increasing numbers of filovirus species and genera have been discovered in recent years.
Na Cui, Yael L. Perez, Adam J. Hume, B. Ethan Nunley, Kevin Kong, Margaret G. Mills, Hong Xie, Alexander L. Greninger   +7 more
doaj   +2 more sources

Correlates of Immunity to Filovirus Infection

Viruses, 2011
Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
Sina Bavari, Steven B. Bradfute
doaj   +3 more sources

Assembly and transport of filovirus nucleocapsids

PLOS Pathogens, 2022
Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs) located in the perinuclear region. The formation of these IBs is induced mainly by the accumulation of the filoviral nucleoprotein NP, which recruits the other ...
O. Dolnik, S. Becker
semanticscholar   +4 more sources

Filovirus VP24 Proteins Differentially Regulate RIG-I and MDA5-Dependent Type I and III Interferon Promoter Activation

Frontiers in Immunology, 2022
Filovirus family consists of highly pathogenic viruses that have caused fatal outbreaks especially in many African countries. Previously, research focus has been on Ebola, Sudan and Marburg viruses leaving other filoviruses less well studied. Filoviruses,
Felix B. He, Hira Khan, Moona Huttunen, Pekka Kolehmainen, Krister Melén, Sari Maljanen, Mengmeng Qu, Miao Jiang, Laura Kakkola, Ilkka Julkunen, Ilkka Julkunen   +10 more
doaj   +2 more sources

In Vivo Investigation of Filovirus Glycoprotein-Mediated Infection in a BSL2 Setting. [PDF]

Methods Mol Biol
Richards PT, Briseño JAA, Brunton BA, Maury W.   +3 more
europepmc   +2 more sources

Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats

Viruses, 2023
Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse, Marinda Mortlock, Antoinette Grobbelaar, Naazneen Moolla, Wanda Markotter, Jacqueline Weyer   +5 more
doaj   +1 more source

Developing Vaccines to Improve Preparedness for Filovirus Outbreaks: The Perspective of the USA Biomedical Advanced Research and Development Authority (BARDA)

Vaccines, 2023
Outbreaks of viral hemorrhagic fever caused by filoviruses have become more prevalent in recent years, with outbreaks of Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV) all occurring in 2022 and 2023.
Lindsay A. Parish, Eric J. Stavale, Christopher R. Houchens, D. Wolfe   +3 more
semanticscholar   +1 more source

A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates. [PDF]

PLoS ONE, 2018
The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections.
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn   +20 more
doaj   +1 more source

Approaches to demonstrating the effectiveness of filovirus vaccines: Lessons from Ebola and COVID-19

Frontiers in Immunology, 2023
Zaire ebolavirus (EBOV), Sudan ebolavirus (SUDV) and Marburg virus (MARV), are members of the Filoviridae family that can cause severe disease and death in humans and animals.
M. Gruber, S. Rubin, P. Krause
semanticscholar   +1 more source

Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors

Acta Pharmaceutica Sinica B, 2018
Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which
Qing Chen, Ke Tang, Xiaoyu Zhang, Panpan Chen, Ying Guo   +4 more
doaj   +1 more source