Results 11 to 20 of about 11,014 (267)
Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses [PDF]
Viruses, 2017 The mononegaviral family Filoviridae has eight members assigned to three genera and seven species. Until now, genus and species demarcation were based on arbitrarily chosen filovirus genome sequence divergence values (≈50% for genera, ≈30% for species ...
Yīmíng Bào +22 more
doaj +3 more sources
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]
eLife, 2015 Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Melinda Ng +20 more
doaj +4 more sources
A novel personal protective equipment for filovirus outbreaks: a usability study under simulated field conditionsINTRODUCTION The 2014 West Africa Ebola outbreak underlined inadequacies of current personal protective equipment (PPE), such as being uncomfortable and hot, causing excessive sweating and rapid exhaustion, and limiting interactions between health ...
Esther Sterk +9 more
semanticscholar +5 more sources
A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses [PDF]
Microbiology SpectrumFiloviruses are some of the most lethal viruses in the modern world, and increasing numbers of filovirus species and genera have been discovered in recent years.
Na Cui +7 more
doaj +2 more sources
Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies [PDF]
Viruses, 2012 The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples ...
Gene G. Olinger +10 more
doaj +2 more sources
Vaccines, 2022 Since the discovery of the Marburg virus (MARV) in 1967 and Ebola virus (EBOV) in 1976, there have been over 40 reported outbreaks of filovirus disease with case fatality rates greater than 50%.
Thomas L. Rudge +7 more
doaj +2 more sources
Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review. [PDF]
PLoS Neglected Tropical Diseases, 2016 BackgroundThe 2013-15 Ebola outbreak was unprecedented due to sustained transmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance about
Julii Brainard +4 more
doaj +4 more sources
Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]
Viruses, 2012 We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Esther Ndungo +7 more
doaj +4 more sources
Contrasting effects of filamin A and B proteins in modulating filovirus entry
PLoS Pathogens, 2023 Ebola (EBOV) and Marburg viruses (MARV) cause severe hemorrhagic fever associated with high mortality rates in humans. A better understanding of filovirus-host interactions that regulate the EBOV and MARV lifecycles can provide biological and mechanistic
Ariel Shepley‐McTaggart +7 more
openalex +3 more sources
Frontiers in Immunology, 2021 Multiple agents in the family Filoviridae (filoviruses) are associated with sporadic human outbreaks of highly lethal disease, while others, including several recently identified agents, possess strong zoonotic potential. Although viral glycoprotein (GP)-
Ariel S. Wirchnianski +13 more
doaj +2 more sources