Results 21 to 30 of about 6,852 (197)

Chaperone-assisted selective autophagy targets filovirus VP40 as a client and restricts egress of virus particles

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Filoviruses EBOV and MARV are zoonotic, emerging pathogens that cause sporadic and global outbreaks of severe hemorrhagic fever. As filoviruses can establish persistent infections in immune-privileged sites inaccessible to antibody therapy ...
Jingjing Liang, Marija A. Djurkovic, O. Shtanko, R. N. Harty   +3 more
semanticscholar   +1 more source

Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses

Viruses, 2017
The mononegaviral family Filoviridae has eight members assigned to three genera and seven species. Until now, genus and species demarcation were based on arbitrarily chosen filovirus genome sequence divergence values (≈50% for genera, ≈30% for species ...
Yīmíng Bào, Gaya K. Amarasinghe, Christopher F. Basler, Sina Bavari, Alexander Bukreyev, Kartik Chandran, Olga Dolnik, John M. Dye, Hideki Ebihara, Pierre Formenty, Roger Hewson, Gary P. Kobinger, Eric M. Leroy, Elke Mühlberger, Sergey V. Netesov, Jean L. Patterson, Janusz T. Paweska, Sophie J. Smither, Ayato Takada, Jonathan S. Towner, Viktor E. Volchkov, Victoria Wahl-Jensen, Jens H. Kuhn   +22 more
doaj   +1 more source

Identifying Suspect Bat Reservoirs of Emerging Infections

Vaccines, 2020
Bats host a number of pathogens that cause severe disease and onward transmission in humans and domestic animals. Some of these pathogens, including henipaviruses and filoviruses, are considered a concern for future pandemics.
Daniel Crowley, Daniel Becker, Alex Washburne, Raina Plowright   +3 more
doaj   +1 more source

Animal Model Alternatives in Filovirus and Bornavirus Research

Viruses, 2023
The order Mononegavirales contains a variety of highly pathogenic viruses that may infect humans, including the families Filoviridae, Bornaviridae, Paramyxoviridae, and Rhabodoviridae.
Lina Widerspick, Johanna Friederike Steffen, D. Tappe, C. Muñoz-Fontela   +3 more
semanticscholar   +1 more source

Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies

Viruses, 2019
Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication.
Md Niaz Rahim, Min Wang, Tong Wang, Shihua He, Bryan D. Griffin, Darwyn Kobasa, Ruifu Yang, Zongmin Du, Xiangguo Qiu   +8 more
doaj   +1 more source

Cryoelectron microscopic structure of the nucleoprotein–RNA complex of the European filovirus, Lloviu virus

PNAS Nexus, 2023
Lloviu virus (LLOV) is a novel filovirus detected in Schreiber's bats in Europe. The isolation of the infectious LLOV from bats has raised public health concerns. However, the virological and molecular characteristics of LLOV remain largely unknown.
Shan Hu, Yoko Fujita-Fujiharu, Yukihiko Sugita, L. Wendt, Y. Muramoto, M. Nakano, T. Hoenen, Takeshi Noda   +7 more
semanticscholar   +1 more source

Filoviruses are ancient and integrated into mammalian genomes

BMC Evolutionary Biology, 2010
Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy, Leach Robert W, Taylor Derek J   +2 more
doaj   +1 more source

Immune response of a two-dose heterologous Ebola vaccine regimen: summary of three African clinical trials using a single validated Filovirus Animal Nonclinical Group enzyme-linked immunosorbent assay in a single accredited laboratory

EBioMedicine, 2023
Summary Background This analysis evaluated the immune response to the two-dose, heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola virus vaccine regimen, administered 56-days apart, from multiple African sites based on results from one analytic laboratory ...
Chelsea McLean, Houreratou Barry, M. Kieh, Zacchaeus Anywaine, Baimba Tapima Rogers, Seydou Doumbia, S. Sirima, Alimamy Serry-Bangura, Abdoul Habib Béavogui, Auguste Gaddah, Michael Katwere, J. Hendriks, Babajide Keshinro, S. Eholie, H. Kibuuka, S. Kennedy, O. Anzala, Mohamed Samai, E. D’Ortenzio, B. Leigh, S. Sow, R. Thiébaut, B. Greenwood, D. Watson-Jones, M. Douoguih, K. Luhn, Cynthia Robinson   +26 more
semanticscholar   +1 more source

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

bioRxiv, 2023
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease.
Yuting Zhang, M. Zhang, Haiyan Wu, Xinwei Wang, Hang Zheng, Junjuan Feng, Jing Wang, Longlong Luo, He Xiao, C. Qiao, Xinying Li, Yuanqiang Zheng, Weijing Huang, Youchun Wang, Yi Wang, Yanchun Shi, Jiannan Feng, Guojiang Chen   +17 more
semanticscholar   +1 more source

Undiscovered Bat Hosts of Filoviruses.

PLoS Neglected Tropical Diseases, 2016
Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high ...
Barbara A Han, John Paul Schmidt, Laura W Alexander, Sarah E Bowden, David T S Hayman, John M Drake   +5 more
doaj   +1 more source