Results 31 to 40 of about 6,852 (197)
Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates. [PDF]
PLoS Neglected Tropical Diseases, 2012 The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (
Chad E Mire +8 more
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Preexisting immunity does not prevent efficacy of VSV-based filovirus vaccines in nonhuman primates.
Journal of Infectious Diseases, 2023 Ebola virus (EBOV) and Marburg virus (MARV) made headlines in the past decade causing outbreaks of human disease in previously nonendemic yet overlapping areas. While EBOV outbreaks can be mitigated with licensed vaccines and treatments, there is not yet
A. Marzi +5 more
semanticscholar +1 more source
Viruses, 2014 On August 22–23, 2013, agencies within the United States Department of Defense (DoD) and the Department of Health and Human Services (HHS) sponsored the Filovirus Medical Countermeasures (MCMs) Workshop as an extension of the activities of the Filovirus ...
Rona Hirschberg +7 more
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Frontiers in Immunology, 2021 Multiple agents in the family Filoviridae (filoviruses) are associated with sporadic human outbreaks of highly lethal disease, while others, including several recently identified agents, possess strong zoonotic potential. Although viral glycoprotein (GP)-
Ariel S. Wirchnianski +13 more
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A Call to Action to Enhance Filovirus Disease Outbreak Preparedness and Response
Viruses, 2014 The frequency and magnitude of recognized and declared filovirus-disease outbreaks have increased in recent years, while pathogenic filoviruses are potentially ubiquitous throughout sub-Saharan Africa.
Paul Roddy
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Contrasting effects of filamin A and B proteins in modulating filovirus entry
PLoS Pathogens, 2023 Ebola (EBOV) and Marburg viruses (MARV) cause severe hemorrhagic fever associated with high mortality rates in humans. A better understanding of filovirus-host interactions that regulate the EBOV and MARV lifecycles can provide biological and mechanistic
Ariel Shepley-McTaggart +7 more
semanticscholar +1 more source
Clinical Management of Filovirus-Infected Patients
Viruses, 2012 Filovirus infection presents many unique challenges to patient management. Currently no approved treatments are available, and the recommendations for supportive care are not evidence based.
Danielle V. Clark +2 more
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Mouse Models for Filovirus Infections [PDF]
Viruses, 2012 The filoviruses marburg- and ebolaviruses can cause severe hemorrhagic fever (HF) in humans and nonhuman primates. Because many cases have occurred in geographical areas lacking a medical research infrastructure, most studies of the pathogenesis of filoviral HF, and all efforts to develop drugs and vaccines, have been carried out in biocontainment ...
Kelly L. Warfield +2 more
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AAV Vectored Immunoprophylaxis for Filovirus Infections [PDF]
Tropical Medicine and Infectious Disease, 2020 Filoviruses are among the deadliest infectious agents known to man, causing severe hemorrhagic fever, with up to 90% fatality rates. The 2014 Ebola outbreak in West Africa resulted in over 28,000 infections, demonstrating the large-scale human health and economic impact generated by filoviruses.
Amira D. Rghei +8 more
openaire +3 more sources
Viruses, 2019 Macrophages are one of the first and also a major site of filovirus replication and, in addition, are a source of multiple cytokines, presumed to play a critical role in the pathogenesis of the viral infection. Some of these cytokines are known to induce
Tzanko S. Stantchev +5 more
doaj +1 more source