Results 51 to 60 of about 9,370 (262)

Drivers of African Filovirus (Ebola and Marburg) Outbreaks.

Vector Borne and Zoonotic Diseases, 2022
Outbreaks of African filoviruses often have high mortality, including more than 11,000 deaths among 28,562 cases during the West Africa Ebola outbreak of 2014-2016.
P. Stephens, Mekala Sundaram, Susana Ferreira, N. Gottdenker, Kaniz Fatema Nipa, A. M. Schatz, J. Schmidt, J. Drake   +7 more
semanticscholar   +1 more source

Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis [PDF]

, 2015
Background The Ebola virus disease outbreak that started in Western Africa in 2013 was unprecedented because it spread within densely populated urban environments and affected many thousands of people.
Baron, Bertherat, Blackley, Burke, Christie, De Roo, Faye, Formenty, Hall, Julii Brainard, Katherine Pond, Kelly Edmunds, Kunii, Lee Hooper, Mackay, McElroy, Moreau, Mupere, Nyenswah, Nyenswah, Nyenswah, Olabode, Paul R Hunter, Schibler, Victory, Vladyko, World Health Organization   +26 more
core   +1 more source

Filoviruses are ancient and integrated into mammalian genomes

BMC Evolutionary Biology, 2010
Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy, Leach Robert W, Taylor Derek J   +2 more
doaj   +1 more source

Detection and characterization of a novel bat filovirus (Dehong virus, DEHV) in fruit bats

bioRxiv, 2023
Although bats are natural hosts of most filoviruses (FiVs), with the pathogenic ones frequently causing deadly haemorrhagic fevers in Africa, the viruses are difficult to trace.
B. He, T. Hu, Xiaomin Yan, Fuqiang Zhang, C. Tu   +4 more
semanticscholar   +1 more source

In Vivo Investigation of Filovirus Glycoprotein-Mediated Infection in a BSL2 Setting. [PDF]

Methods Mol Biol
Richards PT, Briseño JAA, Brunton BA, Maury W.   +3 more
europepmc   +2 more sources

Challenges, Progress, and Opportunities: Proceedings of the Filovirus Medical Countermeasures Workshop

Viruses, 2014
On August 22–23, 2013, agencies within the United States Department of Defense (DoD) and the Department of Health and Human Services (HHS) sponsored the Filovirus Medical Countermeasures (MCMs) Workshop as an extension of the activities of the Filovirus ...
Rona Hirschberg, Lucy A. Ward, Nicole Kilgore, Rebecca Kurnat, Helen Schiltz, Mark T. Albrecht, George W. Christopher, Ed Nuzum   +7 more
doaj   +1 more source

First-in-human study to evaluate safety, tolerability, and immunogenicity of heterologous regimens using the multivalent filovirus vaccines Ad26.Filo and MVA-BN-Filo administered in different sequences and schedules: A randomized, controlled study

PLoS ONE, 2022
Background Though clinically similar, Ebola virus disease and Marburg virus disease are caused by different viruses. Of the 30 documented outbreaks of these diseases in sub-Saharan Africa, eight were major outbreaks (≥200 cases; five caused by Zaire ...
V. Bockstal, Georgi Shukarev, Chelsea McLean, N. Goldstein, S. Bart, Auguste Gaddah, Dickson Anumenden, Jeroen N. Stoop, A. Marit de Groot, M. Pau, J. Hendriks, S. D. De Rosa, Kristen W. Cohen, M. McElrath, Benoît Callendret, K. Luhn, M. Douoguih, Cynthia Robinson   +17 more
semanticscholar   +1 more source

Presence and persistence of Ebola or Marburg virus in patients and survivors: A rapid systematic review [PDF]

, 2016
Background: The 2013-15 Ebola outbreak was unprecedented due to sustainedtransmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance ...
Brainard, Julii, Edmunds, Kelly, Hooper, Lee, Hunter, Paul, Pond, Katherine   +4 more
core   +3 more sources

A Call to Action to Enhance Filovirus Disease Outbreak Preparedness and Response

Viruses, 2014
The frequency and magnitude of recognized and declared filovirus-disease outbreaks have increased in recent years, while pathogenic filoviruses are potentially ubiquitous throughout sub-Saharan Africa.
Paul Roddy
doaj   +1 more source

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity

Frontiers in Immunology, 2021
Multiple agents in the family Filoviridae (filoviruses) are associated with sporadic human outbreaks of highly lethal disease, while others, including several recently identified agents, possess strong zoonotic potential. Although viral glycoprotein (GP)-
Ariel S. Wirchnianski, Ariel S. Wirchnianski, Anna Z. Wec, Elisabeth K. Nyakatura, Andrew S. Herbert, Andrew S. Herbert, Megan M. Slough, Ana I. Kuehne, Eva Mittler, Rohit K. Jangra, Jonathan Teruya, John M. Dye, Jonathan R. Lai, Kartik Chandran   +13 more
doaj   +1 more source