Results 51 to 60 of about 5,905 (203)
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, Volume 58, Issue 11, November 2025.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Viruses, 2019 Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of ...
Francisco J. Zapatero-Belinchón +17 more
doaj +1 more source
Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
Cell Reports, 2020 Summary: Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species.
Yoshihiro Takadate +15 more
doaj +1 more source
Frontiers in Immunology, 2022 Filovirus family consists of highly pathogenic viruses that have caused fatal outbreaks especially in many African countries. Previously, research focus has been on Ebola, Sudan and Marburg viruses leaving other filoviruses less well studied. Filoviruses,
Felix B. He +10 more
doaj +1 more source
Application and comparison of lyophilisation protocols to enhance stable long-term storage of filovirus pseudotypes for use in antibody neutralisation tests [PDF]
, 2022 Martin Mayora Neto +6 more
openalex +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology
Annals of the New York Academy of Sciences, Volume 1550, Issue 1, Page 151-172, August 2025.Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker +11 more
wiley +1 more source
Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID50 Assays [PDF]
, 2021 Patrick T. Keiser +4 more
openalex +1 more source
Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus
The FASEB Journal, Volume 39, Issue 14, 31 July 2025.RSV spreads through three main modes of infection: receptor‐dependent infection of free viral particles, syncytia formation, and transmission via actin filaments. CX3CR1, CCR3, and HSPG mediate viral adsorption; the IGF1R signaling pathway facilitates viral internalization by recruiting NCL to the membrane surface, and the RHO GTPase and PI3K signaling
Han Zhang +3 more
wiley +1 more source
FILOVIRUS TRANSCRIPTION AND REPLICATION [PDF]
, 2014 Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure ...
Kristina Brauburger +2 more
openaire +1 more source