Results 61 to 70 of about 4,767 (201)
Climate Change‐Driven Heatwaves Pose Lethal Risks to Newborn Forest Bats
Ecology and Evolution, Volume 15, Issue 5, May 2025.This is the first recorded case of forest bat mortality in temperate regions caused by heatwaves. The study suggests that forest fragmentation exposes bats to lethal thermal peaks, highlighting a previously overlooked impact of climate change on these mammals and potential interactions with forest fragmentation.
Danilo Russo +6 more
wiley +1 more source
Proteolytic Processing of Filovirus Glycoproteins
, 2018 Filoviruses (Marburg virus and Ebola virus) have a single envelope glycoprotein (GP) that initiates infection. GP is a class I fusion protein that forms trimeric spikes composed of heterodimers of the subunits GP1 and GP2. GP1 and GP2 are derived from the precursor pre-GP by furin cleavage during exocytosis.
Viktor E. Volchkov, Hans-Dieter Klenk
openaire +2 more sources
Vaccines, 2022 The Marburg virus (MARV) and Sudan virus (SUDV) belong to the filovirus family. The sporadic human outbreaks occur mostly in Africa and are characterized by an aggressive disease course with high mortality.
Machteld M. Tiemessen +12 more
doaj +1 more source
Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review
Global Challenges, Volume 9, Issue 5, May 2025.Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze +8 more
wiley +1 more source
Intracellular Events and Cell Fate in Filovirus Infection
Viruses, 2011 Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood
Elena Ryabchikova +3 more
doaj +1 more source
Potential Mammalian Filovirus Reservoirs
Emerging Infectious Diseases, 2004 (Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Peterson, A. Townsend +3 more
openaire +4 more sources
A new player in the puzzle of filovirus entry [PDF]
Nature Reviews Microbiology, 2012 Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore,
Judith M. White, Kathryn L. Schornberg
openaire +3 more sources
Establishment of fruit bat cells (Rousettus aegyptiacus) as a model system for the investigation of filoviral infection. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND: The fruit bat species Rousettus aegyptiacus was identified as a potential reservoir for the highly pathogenic filovirus Marburg virus. To establish a basis for a molecular understanding of the biology of filoviruses in the reservoir host, we ...
Verena Krähling +7 more
doaj +1 more source
mBio, 2016 The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immune ...
Zachary A. Bornholdt +7 more
doaj +1 more source
European Journal of Organic Chemistry, Volume 28, Issue 8, February 24, 2025.There are continuous efforts to improve total syntheses of natural products, particularly their sustainability, such as developing effective chiral pool approaches relying on a wide spectrum of natural chirons, including (−)‐sclareol as one of the most useful natural chirons.
Ayyoub Selka +5 more
wiley +1 more source