Results 61 to 70 of about 6,852 (197)

Cellular Factors Implicated in Filovirus Entry [PDF]

Advances in Virology, 2013
Although filoviral infections are still occurring in different parts of the world, there are no effective preventive or treatment strategies currently available against them. Not only do filoviruses cause a deadly infection, but they also have the potential of being used as biological weapons.
Suchita Bhattacharyya, Thomas J. Hope
openaire   +3 more sources

Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing. [PDF]

PLoS ONE, 2014
A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus allowing for appropriate therapeutic and containment procedures.
Jeffrey W Koehler, Adrienne T Hall, P Alexander Rolfe, Anna N Honko, Gustavo F Palacios, Joseph N Fair, Jean-Jacques Muyembe, Prime Mulembekani, Randal J Schoepp, Adeyemi Adesokan, Timothy D Minogue   +10 more
doaj   +1 more source

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

Cutaneous manifestations of filovirus infections

International Journal of Dermatology, 2012
AbstractEbolavirus and Marburgvirus, two filoviruses belonging to the Filoviridae family, are among the most virulent pathogens for humans and non‐human primates, causing outbreaks of fulminant hemorrhagic fever (HF) in Central African countries with case fatality rates of up to 90%.
Nkoghe, D., /Leroy, Eric, Toung-Mve, M., /Gonzalez, Jean-Paul   +3 more
openaire   +3 more sources

Isolation, characterization, and circulation sphere of a filovirus in fruit bats

Proceedings of the National Academy of Sciences of the United States of America
Significance Filoviruses (FiVs) often trigger devastating infectious diseases in Africa, but their natural origin and distribution remain largely unclear, though bats are deeply associated with their circulation.
Biao He, T. Hu, Xiaomin Yan, Yanhui Pa, Yuhang Liu, Yang Liu, Nan Li, Jing Yu, Hailin Zhang, Yonghua Liu, Jun Chai, Y. Sun, S. Mi, Yan Liu, Le Yi, Zhongzhong Tu, Yiyin Wang, Sheng Sun, Ye Feng, Wen-dong Zhang, Huan-yun Zhao, Bofang Duan, W. Gong, Fuqiang Zhang, Changchun Tu   +24 more
semanticscholar   +1 more source

Immune Correlates of Protection from Filovirus Efficacy Studies in Non-Human Primates

Vaccines, 2022
Non-human primate (NHP) efficacy data for several Ebola virus (EBOV) vaccine candidates exist, but definitive correlates of protection (CoP) have not been demonstrated, although antibodies to the filovirus glycoprotein (GP) antigen and other ...
Cheryl A Triplett, N. Niemuth, Chris M Cirimotich, G. Meister, M. Guebre‐Xabier, N. Patel, M. Massare, G. Glenn, Gale Smith, Kendra J Alfson, Yenny Goez-Gazi, R. Carrion   +11 more
semanticscholar   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Filovirius vaccines [PDF]

Human Vaccines, 2011
Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses.
Steven B, Bradfute, John M, Dye, Sina, Bavari   +2 more
openaire   +2 more sources

Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease

BMC Infectious Diseases, 2018
Background Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and international spread.
Peace Babirye, Carol Musubika, Samuel Kirimunda, Robert Downing, Julian J Lutwama, Edward K Mbidde, Jacqueline Weyer, Janusz T Paweska, Moses L Joloba, Misaki Wayengera   +9 more
doaj   +1 more source

Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea

Nature Communications
Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. To characterise filovirus zoonotic exposure, we collected cross-sectional serum samples from bushmeat ...
Joseph Akoi Boré, J. Timothy, T. Tipton, Ifono Kekoura, Y. Hall, Grace Hood, S. Longet, Kimberly Fornace, Millimono S Lucien, Sarah Katarina Fehling, Beatrice K Koivogui, S. Coggins, E. Laing, Christopher C. Broder, N. Magassouba, Thomas Strecker, J. Rossman, Kader Konde, M. W. Carroll   +18 more
semanticscholar   +1 more source