Results 71 to 80 of about 6,852 (197)

Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID50 Assays

Microorganisms, 2021
Ongoing efforts to develop effective therapies against filoviruses rely, to different extents, on quantifying the amount of viable virus in samples by plaque, TCID50, and focus assays.
P. Keiser, Manu Anantpadma, Hilary M Staples, R. Carrion, R. Davey   +4 more
semanticscholar   +1 more source

New filovirus disease classification and nomenclature [PDF]

Nature Reviews Microbiology, 2019
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
J. Kuhn, T. Adachi, N. Adhikari, J. Arribas, Ibrahima Bah, D. Bausch, N. Bhadelia, M. Borchert, A. Brantsæter, D. Brett-Major, T. Burgess, Daniel S. Chertow, C. Chute, T. Cieslak, R. Colebunders, Ian Crozier, R. Davey, Hilde de Clerck, R. Delgado, Laura Evans, Mosoka P. Fallah, W. Fischer, T. Fletcher, R. Fowler, T. Grünewald, Andrew Hall, Angela L Hewlett, A. Hoepelman, C. Houlihan, G. Ippolito, Shevin T. Jacob, M. Jacobs, Robert Jakob, F. Jacquerioz, L. Kaiser, A. Kalil, R. Kamara, J. Kapetshi, H. Klenk, G. Kobinger, M. Kortepeter, C. Kraft, T. Kratz, H. K. Bosa, M. Lado, F. Lamontagne, H. Lane, L. Lobel, J. Lutwama, G. Lyon, M. Massaquoi, T. Massaquoi, A. Mehta, Vital Mondonge Makuma, S. Murthy, Tonny Seikikongo Musoke, J. Muyembe‐Tamfum, Phiona Nakyeyune, Carolina Nanclares, M. Nanyunja, Justus Nsio-Mbeta, T. O'dempsey, J. Pawęska, C. Peters, P. Piot, C. Rapp, B. Renaud, B. Ribner, Pardis C Sabeti, J. Schieffelin, W. Slenczka, Moses J. Soka, A. Sprecher, J. Strong, R. Swanepoel, T. Uyeki, M. van Herp, P. Vetter, D. Wohl, T. Wolf, Anja Wolz, Alie H. Wurie, Z. Yoti   +82 more
semanticscholar   +9 more sources

In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP‐40

BioMed Research International, Volume 2026, Issue 1, 2026.
The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola virus.
Boniface Omara, Kenedy Kiyimba, Fatoumata G. Fofana, Oudou Diabaté, Walter Odur, Daudi Jjingo, Jacob Stanley Iramiot, Peace Draleru, Joan Achia, Muhammad Shafiq, Zaheer Ul-Haq, Hedmon Okella, Steven Odongo, Swaran J. S. Flora   +13 more
wiley   +1 more source

Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors

Viruses, 2019
Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of ...
Francisco J. Zapatero-Belinchón, Erik Dietzel, Olga Dolnik, Katinka Döhner, Rui Costa, Barbara Hertel, Barbora Veselkova, Jared Kirui, Anneke Klintworth, Michael P. Manns, Stefan Pöhlmann, Thomas Pietschmann, Thomas Krey, Sandra Ciesek, Gisa Gerold, Beate Sodeik, Stephan Becker, Thomas von Hahn   +17 more
doaj   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

Cell Reports, 2020
Summary: Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species.
Yoshihiro Takadate, Tatsunari Kondoh, Manabu Igarashi, Junki Maruyama, Rashid Manzoor, Hirohito Ogawa, Masahiro Kajihara, Wakako Furuyama, Masahiro Sato, Hiroko Miyamoto, Reiko Yoshida, Terence E. Hill, Alexander N. Freiberg, Heinz Feldmann, Andrea Marzi, Ayato Takada   +15 more
doaj   +1 more source

Application and comparison of lyophilisation protocols to enhance stable long-term storage of filovirus pseudotypes for use in antibody neutralisation tests

bioRxiv, 2022
Filoviruses encompass highly pathogenic viruses placing sporadic public health burden on countries affected. Efforts for improved diagnostics and surveillance are needed considering the recent Ebola outbreaks in Africa.
M. Neto, E. Wright, N. Temperton, Peter Soema, R. Ten Have, I. Ploemen, S. Scott   +6 more
semanticscholar   +1 more source

Production of human cathepsins using Expi293™ mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of antivirals targeting cysteine proteases will emerge.
Zoe Turner, Elena Arutyunova, Duong T. Bui, Ling Han, Appan Srinivas Kandadai, Bing Bai, Howard S. Young, Lara K. Mahal, John S. Klassen, M. Joanne Lemieux   +9 more
wiley   +1 more source

Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

PLoS Pathogens
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance.
A. Wirchnianski, E. Nyakatura, A. Herbert, A. Kuehne, Shawn A. Abbasi, Catalina Florez, Nadia Storm, Lindsay G. A. McKay, Leandrew Dailey, Erin A. Kuang, Dafna M. Abelson, Anna Z. Wec, Srinjoy Chakraborti, Frederick W. Holtsberg, S. Shulenin, Z. Bornholdt, M. Aman, A. Honko, Anthony Griffiths, J. Dye, K. Chandran, Jonathan R. Lai   +21 more
semanticscholar   +1 more source

Marburg Virus Persistence on Fruit as a Plausible Route of Bat to Primate Filovirus Transmission

Viruses, 2021
Marburg virus (MARV), the causative agent of Marburg virus disease, emerges sporadically in sub-Saharan Africa and is often fatal in humas. The natural reservoir for this zoonotic virus is the frugivorous Egyptian rousette bat (Rousettus aegyptiacus ...
B. Amman, A. Schuh, C. Albariño, J. Towner   +3 more
semanticscholar   +1 more source