Results 71 to 80 of about 11,014 (267)

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates.

PLoS ONE, 2014
The filoviruses, Marburg virus (MARV) and Ebola virus, causes severe hemorrhagic fever with high mortality in humans and nonhuman primates. A promising filovirus vaccine under development is based on a recombinant vesicular stomatitis virus (rVSV) that ...
Chad E Mire, Joan B Geisbert, Krystle N Agans, Benjamin A Satterfield, Krista M Versteeg, Elizabeth A Fritz, Heinz Feldmann, Lisa E Hensley, Thomas W Geisbert   +8 more
doaj   +1 more source

Drivers of African Filovirus (Ebola and Marburg) Outbreaks

Vector Borne and Zoonotic Diseases, 2022
Outbreaks of African filoviruses often have high mortality, including more than 11,000 deaths among 28,562 cases during the West Africa Ebola outbreak of 2014–2016.
P. Stephens, Mekala Sundaram, Susana Ferreira, N. Gottdenker, Kaniz Fatema Nipa, A. M. Schatz, J. Schmidt, J. Drake   +7 more
semanticscholar   +1 more source

Filovirus Replication and Transcription [PDF]

Future Virology, 2007
The highly pathogenic filoviruses, Marburg and Ebola virus, belong to the nonsegmented negative-sense RNA viruses of the order Mononegavirales. The mode of replication and transcription is similar for these viruses. On one hand, the negative-sense RNA genome serves as a template for replication, to generate progeny genomes, and, on the other hand, for ...
openaire   +2 more sources

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

An Interagency Collaboration to Facilitate Development of Filovirus Medical Countermeasures

Viruses, 2012
The Filovirus Animal Non-Clinical Group (FANG) is a US interdepartmental and interagency group established to support and facilitate the advanced development of filovirus Medical Countermeasures (MCM), both vaccines and therapeutics.
Edwin O. Nuzum, Nicole Kilgore
doaj   +1 more source

Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1

Nature Communications
SARS-CoV-2 and filovirus enter cells via the cell surface angiotensin-converting enzyme 2 (ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor.
Ilyas Khan, Sunan Li, Lihong Tao, Chong Wang, Bowei Ye, Huiyung Li, Xiaoyang Liu, Iqbal Ahmad, Wenqiang Su, Gongxun Zhong, Zhiyuan Wen, Jinliang Wang, Rong-Hong Hua, Ao Ma, Jie Liang, Xiao-Peng Wan, Zhi-Gao Bu, Yong-Hui Zheng   +17 more
semanticscholar   +1 more source

Potential Mammalian Filovirus Reservoirs

Emerging Infectious Diseases, 2004
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Peterson, A. Townsend, Carroll, Darin S., Mills, James N., Johnson, Karl M.   +3 more
openaire   +2 more sources

Plant phenology supports the multi-emergence hypothesis for ebola spillover events [PDF]

, 2017
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored.
Douglas, Noah E., Isokpehi, Raphael D., Johnson, Brianna, McGill, Ayana, Sivasundaram, Seenith, Wollenberg Valero, Katharina C., Wootson, Kiara   +6 more
core   +1 more source

Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing. [PDF]

PLoS ONE, 2014
A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus allowing for appropriate therapeutic and containment procedures.
Jeffrey W Koehler, Adrienne T Hall, P Alexander Rolfe, Anna N Honko, Gustavo F Palacios, Joseph N Fair, Jean-Jacques Muyembe, Prime Mulembekani, Randal J Schoepp, Adeyemi Adesokan, Timothy D Minogue   +10 more
doaj   +1 more source

Detection and characterization of a novel bat filovirus (Dehong virus, DEHV) in fruit bats

bioRxiv, 2023
Although bats are natural hosts of most filoviruses (FiVs), with the pathogenic ones frequently causing deadly haemorrhagic fevers in Africa, the viruses are difficult to trace.
B. He, T. Hu, Xiaomin Yan, Fuqiang Zhang, C. Tu   +4 more
semanticscholar   +1 more source