Results 71 to 80 of about 9,370 (262)

Ebola Haemorrhagic Fever in Africa: a Necessary Highlight [PDF]

, 2019
The purpose of this commentary is to re-evaluate the historic and scientific facts on Ebola haemorrhagic fever and the role of the International community, especially Economic Community of West African States (ECOWAS) in stemming the tide.
Adu-Gyamfi, S. (Samuel)
core   +3 more sources

Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions

Viruses, 2012
Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics.
Suchita Bhattacharyya, Kartik Chandran, Nirupama Mulherkar   +2 more
doaj   +1 more source

Isolation, characterization, and circulation sphere of a filovirus in fruit bats

Proceedings of the National Academy of Sciences of the United States of America
Significance Filoviruses (FiVs) often trigger devastating infectious diseases in Africa, but their natural origin and distribution remain largely unclear, though bats are deeply associated with their circulation.
Biao He, T. Hu, Xiaomin Yan, Yanhui Pa, Yuhang Liu, Yang Liu, Nan Li, Jing Yu, Hailin Zhang, Yonghua Liu, Jun Chai, Y. Sun, S. Mi, Yan Liu, Le Yi, Zhongzhong Tu, Yiyin Wang, Sheng Sun, Ye Feng, Wen-dong Zhang, Huanyun Zhao, Bofang Duan, W. Gong, Fuqiang Zhang, Changchun Tu   +24 more
semanticscholar   +1 more source

FILOVIRUS TRANSCRIPTION AND REPLICATION [PDF]

, 2014
Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure ...
Kristina Brauburger, Laure R. Deflubé, Elke Mühlberger   +2 more
openaire   +2 more sources

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]

, 2008
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher, Anon., Baize, Basler, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Benjamin Jeffs, Bernard, Borchert, Bosio, Bosio, Boumandouki, Bray, Bray, Bray, Bray, Brummel-Ziedins, Bukreyev, Bwaka, CDC and WHO, Colebunders, Daddario-DiCaprio, Daniel G. Bausch, Dowell, Egbring, Emond, Enterlein, Feldmann, Formenty, Fourrier, Gear, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Gibbs, Gupta, Hensley, Hensley, Hensley, Hewlett, Hewlett, Hoenen, Hotchkiss, Huggins, Jahrling, Jahrling, Jahrling, Jeffs, Johnson, Jones, Jones, Khan, Ksiazek, Kudoyarova-Zubavichene, Larkin, Leroy, Leroy, Mahanty, Mahanty, Martin, Martini, Martini, Monath, Mupapa, Mupapa, Nikiforov, Oswald, Parrino, Pattyn, Paul Boumandouki, Peters, Peterson, Peterson, Pourrut, Reid, Rivers, Roberts, Rollin, Sanchez, Schnittler, Schuler, Smith, Spurgers, Stille, Sullivan, Sullivan, Swanepoel, Takada, Todorovitch, Towner, Warfield, Warfield, Warfield, Wilson, Zaki   +105 more
core   +2 more sources

Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1

Nature Communications
SARS-CoV-2 and filovirus enter cells via the cell surface angiotensin-converting enzyme 2 (ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor.
Ilyas Khan, Sunan Li, Lihong Tao, Chong Wang, Bowei Ye, Huiyung Li, Xiaoyang Liu, Iqbal Ahmad, Wenqiang Su, Gongxun Zhong, Zhiyuan Wen, Jinliang Wang, Rong-Hong Hua, Ao Ma, Jie Liang, Xiao-Peng Wan, Zhi-Gao Bu, Yong-Hui Zheng   +17 more
semanticscholar   +1 more source

A retrospective cohort investigation of seroprevalence of Marburg virus and ebolaviruses in two different ecological zones in Uganda

BMC Infectious Diseases, 2020
Background Uganda has experienced seven Ebola Virus Disease (EVD) outbreaks and four Marburg Virus Disease (MVD) outbreaks between 2000 and 2019. We investigated the seroprevalence and risk factors for Marburg virus and ebolaviruses in gold mining ...
Luke Nyakarahuka, Ilana J. Schafer, Stephen Balinandi, Sophia Mulei, Alex Tumusiime, Jackson Kyondo, Barbara Knust, Julius Lutwama, Pierre Rollin, Stuart Nichol, Trevor Shoemaker   +10 more
doaj   +1 more source

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates.

PLoS ONE, 2014
The filoviruses, Marburg virus (MARV) and Ebola virus, causes severe hemorrhagic fever with high mortality in humans and nonhuman primates. A promising filovirus vaccine under development is based on a recombinant vesicular stomatitis virus (rVSV) that ...
Chad E Mire, Joan B Geisbert, Krystle N Agans, Benjamin A Satterfield, Krista M Versteeg, Elizabeth A Fritz, Heinz Feldmann, Lisa E Hensley, Thomas W Geisbert   +8 more
doaj   +1 more source

An Interagency Collaboration to Facilitate Development of Filovirus Medical Countermeasures

Viruses, 2012
The Filovirus Animal Non-Clinical Group (FANG) is a US interdepartmental and interagency group established to support and facilitate the advanced development of filovirus Medical Countermeasures (MCM), both vaccines and therapeutics.
Edwin O. Nuzum, Nicole Kilgore
doaj   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source