Results 71 to 80 of about 4,767 (201)
Ebolavirus evolution and emergence are associated with land use change
Ecological Monographs, Volume 95, Issue 1, February 2025.Abstract Anthropogenic land use change facilitates disease emergence by altering the interface between humans and pathogen reservoirs and is hypothesized to drive pathogen evolution. Here, we show a positive association between land use change and the evolution and dispersal of Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV).
Christian E. Lange +8 more
wiley +1 more source
Modern building structures are a landscape‐level driver of bat–human exposure risk in Kenya
Frontiers in Ecology and the Environment, Volume 23, Issue 1, February 2025.Identifying the locations and drivers of high‐risk interfaces between humans and wildlife is crucial for managing zoonotic disease risk. We suggest that continent‐wide improvements to residential housing in Africa are inadvertently creating artificial roosting habitat for synanthropic free‐tailed bats (family Molossidae), and that improved buildings ...
Tamika J Lunn +4 more
wiley +1 more source
Filovirus Entry: A Novelty in the Viral Fusion World [PDF]
Viruses, 2012 Ebolavirus (EBOV) and Marburgvirus (MARV) that compose the filovirus family of negative strand RNA viruses infect a broad range of mammalian cells. Recent studies indicate that cellular entry of this family of viruses requires a series of cellular protein interactions and molecular mechanisms, some of which are unique to filoviruses and others are ...
Catherine L. Hunt +2 more
openaire +3 more sources
Infectious Subgenomic Amplicon Strategies for Japanese Encephalitis and West Nile Viruses
Journal of Medical Virology, Volume 97, Issue 2, February 2025.ABSTRACT Classical methods for constructing infectious cDNA clones of flaviviruses are often hindered by instability and toxicity. The Infectious‐Subgenomic‐Amplicons (ISA) method is an advancement which utilizes overlapping DNA fragments representing viral genomic sequence and in‐cell recombination to bypass bacterial plasmid assembly.
Prince Pal Singh +2 more
wiley +1 more source
PLoS Neglected Tropical Diseases, 2016 BackgroundThe 2013-15 Ebola outbreak was unprecedented due to sustained transmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance about
Julii Brainard +4 more
doaj +1 more source
Exploring the druggability of the UEV domain of human TSG101 in search for broad‐spectrum antivirals
Protein Science, Volume 34, Issue 1, January 2025.Abstract The ubiquitin E2 variant domain of TSG101 (TSG101‐UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101‐UEV/PTAP interactions has emerged as a promising strategy for the development of host‐oriented broad‐spectrum antivirals with low susceptibility to ...
Fernando Montero +17 more
wiley +1 more source
Filoviruses: One of These Things is (not) Like the Other
Viruses, 2015 The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus
Scott M. Anthony, Steven B. Bradfute
doaj +1 more source
Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Safietou Sankhe +17 more
wiley +1 more source
The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study
Ecology and Evolution, Volume 14, Issue 11, November 2024.Through the evolutionary and bibliometric analyses, this study identified several critical immune genes and signaling pathways related to bat immunity. Currently, research on the immune system of bats primarily focuses on the themes of “efficient antiviral responses” and “inflammation suppression.” ABSTRACT Bats exhibit a greater capacity to tolerate ...
Rui Li +4 more
wiley +1 more source
PLoS Pathogens, 2019 There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen.
Md Niaz Rahim +11 more
doaj +1 more source