Results 81 to 90 of about 6,852 (197)
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, Volume 58, Issue 11, November 2025.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies
Viruses, 2012 The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples ...
Gene G. Olinger +10 more
doaj +1 more source
Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
Cell Reports, 2020 Ebola virus causes severe hemorrhagic fever, often leading to death in humans. The trimeric fusion glycoprotein (GP) is the sole target for neutralizing antibodies and is the major focus of vaccine development.
L. Rutten +5 more
semanticscholar +1 more source
Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health
Microbial Biotechnology, Volume 18, Issue 9, September 2025.Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley +1 more source
FILOVIRUS TRANSCRIPTION AND REPLICATION [PDF]
, 2014 Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure ...
Kristina Brauburger +2 more
openaire +1 more source
Filovirus Mimics Deliver Effectively [PDF]
Biophysical Journal, 2016 Filoviruses such as Ebola are microns long but biophysical advantages for such encapsulating/enveloped viruses have remained obscure. Flexible ‘filomicelles’ have been made from amphiphilic block copolymers and demonstrate effective delivery of two very different hydrophobic compounds.
Nair, Praful R. +4 more
openaire +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Intracellular Events and Cell Fate in Filovirus Infection
Viruses, 2011 Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood
Elena Ryabchikova +3 more
doaj +1 more source
A novel personal protective equipment for filovirus outbreaks: a usability study under simulated field conditionsINTRODUCTION The 2014 West Africa Ebola outbreak underlined inadequacies of current personal protective equipment (PPE), such as being uncomfortable and hot, causing excessive sweating and rapid exhaustion, and limiting interactions between health ...
E. Sterk +9 more
semanticscholar +1 more source
Persistence and Organ Tropism of Filoviruses in Farmed European Perch (Perca fluviatilis)
Journal of Fish Diseases, EarlyView.
Johanna Perschthaler +4 more
wiley +1 more source