Results 81 to 90 of about 11,014 (267)
ChemistryOpen, Volume 14, Issue 12, December 2025.DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman +5 more
wiley +1 more source
Cellular Factors Implicated in Filovirus Entry [PDF]
Advances in Virology, 2013 Although filoviral infections are still occurring in different parts of the world, there are no effective preventive or treatment strategies currently available against them. Not only do filoviruses cause a deadly infection, but they also have the potential of being used as biological weapons.
Suchita Bhattacharyya, Thomas J. Hope
openaire +3 more sources
BMC Infectious Diseases, 2018 Background Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and international spread.
Peace Babirye +9 more
doaj +1 more source
Protein Science, Volume 34, Issue 11, November 2025.Abstract Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of antivirals targeting cysteine proteases will emerge.
Zoe Turner +9 more
wiley +1 more source
Cutaneous manifestations of filovirus infections
International Journal of Dermatology, 2012 AbstractEbolavirus and Marburgvirus, two filoviruses belonging to the Filoviridae family, are among the most virulent pathogens for humans and non‐human primates, causing outbreaks of fulminant hemorrhagic fever (HF) in Central African countries with case fatality rates of up to 90%.
Nkoghe, D. +3 more
openaire +3 more sources
Ebola Haemorrhagic Fever in Africa: a Necessary Highlight [PDF]
, 2019 The purpose of this commentary is to re-evaluate the historic and scientific facts on Ebola haemorrhagic fever and the role of the International community, especially Economic Community of West African States (ECOWAS) in stemming the tide.
Adu-Gyamfi, S. (Samuel)
core +3 more sources
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, Volume 58, Issue 11, November 2025.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Human Vaccines, 2011 Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses.
Steven B, Bradfute +2 more
openaire +2 more sources
PLoS ONE, 2022 Background Though clinically similar, Ebola virus disease and Marburg virus disease are caused by different viruses. Of the 30 documented outbreaks of these diseases in sub-Saharan Africa, eight were major outbreaks (≥200 cases; five caused by Zaire ...
Viki Bockstal +17 more
semanticscholar +1 more source
Viruses, 2019 Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of ...
Francisco J. Zapatero-Belinchón +17 more
doaj +1 more source