Results 81 to 90 of about 8,401 (235)
A new player in the puzzle of filovirus entry [PDF]
Nature Reviews Microbiology, 2012 Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore,
Judith M. White, Kathryn L. Schornberg
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High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo [PDF]
, 2016 Background Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub- Saharan Africa.
Afounde, Afongenda +8 more
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mBio, 2016 The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immune ...
Zachary A. Bornholdt +7 more
doaj +1 more source
, 2020 Characteristics of the family Filoviridae and the Ebola virus: an update of its implications in the human population The family Filoviridae is integrated by a group of filamentous RNA viruses that cause severe hemorrhagic fevers in primates and other ...
Burgueño-Sosa, E. +3 more
core +1 more source
Antibody quality and protection from lethal ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine. [PDF]
, 2013 We have previously described the generation of a novel Ebola virus (EBOV) vaccine platform based on (a) replication-competent rabies virus (RABV), (b) replication-deficient RABV, or (c) chemically inactivated RABV expressing EBOV glycoprotein (GP). Mouse
Blaney, Joseph E +9 more
core +4 more sources
Infectious Subgenomic Amplicon Strategies for Japanese Encephalitis and West Nile Viruses
Journal of Medical Virology, Volume 97, Issue 2, February 2025.ABSTRACT Classical methods for constructing infectious cDNA clones of flaviviruses are often hindered by instability and toxicity. The Infectious‐Subgenomic‐Amplicons (ISA) method is an advancement which utilizes overlapping DNA fragments representing viral genomic sequence and in‐cell recombination to bypass bacterial plasmid assembly.
Prince Pal Singh +2 more
wiley +1 more source
Establishment of fruit bat cells (Rousettus aegyptiacus) as a model system for the investigation of filoviral infection. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND: The fruit bat species Rousettus aegyptiacus was identified as a potential reservoir for the highly pathogenic filovirus Marburg virus. To establish a basis for a molecular understanding of the biology of filoviruses in the reservoir host, we ...
Verena Krähling +7 more
doaj +1 more source
Exploring the druggability of the UEV domain of human TSG101 in search for broad‐spectrum antivirals
Protein Science, Volume 34, Issue 1, January 2025.Abstract The ubiquitin E2 variant domain of TSG101 (TSG101‐UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101‐UEV/PTAP interactions has emerged as a promising strategy for the development of host‐oriented broad‐spectrum antivirals with low susceptibility to ...
Fernando Montero +17 more
wiley +1 more source
Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal
Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Safietou Sankhe +17 more
wiley +1 more source
Filovirus Entry: A Novelty in the Viral Fusion World [PDF]
Viruses, 2012 Ebolavirus (EBOV) and Marburgvirus (MARV) that compose the filovirus family of negative strand RNA viruses infect a broad range of mammalian cells. Recent studies indicate that cellular entry of this family of viruses requires a series of cellular protein interactions and molecular mechanisms, some of which are unique to filoviruses and others are ...
Catherine L. Hunt +2 more
openaire +3 more sources