Results 101 to 110 of about 9,748 (234)

“Filoviruses”: a real pandemic threat?

EMBO Molecular Medicine, 2009
Filoviruses are zoonotic and among the deadliest viruses known to mankind, with mortality rates in outbreaks reaching up to 90%. Despite numerous efforts to identify the host reservoir(s), the transmission cycle of filoviruses between the animal host(s) and humans remains unclear.
Martina, Byron EE, Osterhaus, Albert DME
openaire   +2 more sources

Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using Drosophila S2 Cells

Engineering in Life Sciences, Volume 25, Issue 5, May 2025.
ABSTRACT Marburg marburgvirus (MARV) is a highly virulent human pathogen with limited therapeutic options. Recombinant MARV glycoprotein (GP) produced in Drosophila Schneider 2 (S2) cells has been extensively investigated as potential vaccine antigen with promising efficacy demonstrated in nonhuman primate models.
Sven Göbel, Ludwig Mayerlen, Isabelle Yazel Eiser, Lisa Fichtmueller, David Clements, Udo Reichl, Yvonne Genzel, AxelT. Lehrer   +7 more
wiley   +1 more source

Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies

Antibodies
Ebola virus disease (EVD) is an acute illness with a high-case fatality rate (CFR) caused by an RNA virus belonging to the Filoviridae family. Over the past 50 years, regular EVD outbreaks have been reported.
Dmitriy N. Shcherbakov, Anastasiya A. Isaeva, Egor A. Mustaev   +2 more
doaj   +1 more source

Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names [PDF]

, 2014
Sequence determination of complete or coding-complete genomes of viruses is becoming common practice for supporting the work of epidemiologists, ecologists, virologists, and taxonomists.
Andersen, Kristian G., Bavari, Sina, Becker, Stephan, Bennett, Richard S., Bergman, Nicholas H., Blinkova, Olga, Bradfute, Steven, Brister, J. Rodney, Bukreyev, Alexander, Bào, Yīmíng, Chandran, Kartik, Chepurnov, Alexander A., Davey, Robert A., Dietzgen, Ralf G., Doggett, Norman A., Dolnik, Olga, Dye, John M., Enterlein, Sven, Fenimore, Paul W., Formenty, Pierre, Freiberg, Alexander N., Garry, Robert F., Garza, Nicole L., Gire, Stephen K., Gonzalez, Jean-Paul, Griffiths, Anthony, Happi, Christian T., Hensley, Lisa E., Herbert, Andrew S., Hevey, Michael C., Hoenen, Thomas, Honko, Anna N., Ignatyev, Georgy M., Jahrling, Peter B., Johnson, Joshua C., Johnson, Karl M., Kindrachuk, Jason, Klenk, Hans-Dieter, Kobinger, Gary, Kochel, Tadeusz J., Kuhn, Jens H., Lackemeyer, Matthew G., Lackner, Daniel F., Leroy, Eric M., Lever, Mark S., Mühlberger, Elke, Netesov, Sergey V., Nichol, Stuart T., Olinger, Gene G., Omilabu, Sunday A., Palacios, Gustavo, Panchal, Rekha G., Park, Daniel J., Patterson, Jean L., Paweska, Janusz T., Peters, Clarence J., Pettitt, James, Pitt, Louise, Radoshitzky, Sheli R., Ryabchikova, Elena I., Sabeti, Pardis C., Saphire, Erica Ollmann, Sealfon, Rachel, Shestopalov, Aleksandr M., Smither, Sophie J., Sullivan, Nancy J., Swanepoel, Robert, Takada, Ayato, Towner, Jonathan S., van der Groen, Guido, Volchkov, Viktor E., Volchkova, Valentina A., Wahl-Jensen, Victoria, Warfield, Kelly L., Warren, Travis K., Weidmann, Manfred   +75 more
core   +3 more sources

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, Volume 9, Issue 5, May 2025.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses [PDF]

, 2018
Background With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible to ...
AC Banyard, AGD Bean, B Hu, CR Gaush, D Bernasconi, D Dlugolenski, DS Poole, EA Govorkova, GS Freidl, I Eckerle, I Ramos, Isabella Eckerle, J Stevens, J Xie, K Shuai, Kin-Chow Chang, M Delgado-Ortega, M Hoffman, M Juozapaitis, O Planz, R Pinto, RK Nelli, RK Nelli, S Matikainen, S Panzer, S Tong, SH Seo, SJ Gamblin, SV Kuchipudi, Tessa Slater, V Sandekian, W Weis, Y Wu   +32 more
core   +3 more sources

Filovirus infections: science and innovation

Сибирский научный медицинский журнал
Epidemics of Filovirus Hemorrhagic Fevers demonstrate an increase in incidence, a reduction in the intervals between outbreaks, the emergence of a risk of infection spreading to non-endemic regions in recent years.
L. N. Aftaeva, V. L. Melnikov, A. V. Arekhina   +2 more
doaj   +1 more source

Inhibition of Ebola Virus by Anti-Ebola miRNAs in silico

Journal of Infection in Developing Countries, 2016
Introduction: MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate transcriptional and posttranscriptional gene regulation of the organisms. miRNA provides immune defense when the body is faced with challenges intracellular agents.
Zhabiz Golkar, Roshan Battaria, Donald G Pace, Omar Bagasra   +3 more
doaj   +1 more source

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]

, 2012
We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Chandran, Kartik, Dye, John M., Herbert, Andrew S., Krishnan, Anuja, Miller, Emily Happy, Ndungo, Esther, Ng, Melinda, Whelan, Sean P.J.   +7 more
core   +2 more sources

The Molecular Genetic Peculiarities of Genomic Structure of Members of the Ebolavirus Genus

Проблемы особо опасных инфекций, 2015
The molecular genetic peculiarities of genomic structure of the Ebolavirus genus members are viewed in the review. The Ebola virus disease outbreaks in West African countries constitute a threat not only for Africa, but for the whole world in view of ...
A. A. Petrov, V. N. Lebedev, L. F. Stovba, T. E. Sizikova, T. M. Plekhanova, O. N. Sidorova, N. S. Pyshnaya, D. I. Paveliev, S. V. Borisevich   +8 more
doaj   +1 more source