Filoviruses are ancient and integrated into mammalian genomes [PDF]
BMC Evolutionary Biology, 2010 Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine. Although there is evidence that wild mammals are infected by filoviruses, the biology of host-filovirus systems is notoriously poorly understood.
Derek J. Taylor +2 more
openaire +8 more sources
OVERVIEW OF RHABDO- AND FILOVIRUSES [PDF]
, 2014 Summary Enveloped viruses with a negative-sense, single-stranded monopartite RNA genome have been classified into the order Mononegavirales. Five families of viruses that constitute the order are: Rhabdoviridae, Filoviridae, Paramyxoviridae, Bornaviridae and Nyamiviridae.
Pattnaik, Asit K., Whitt, Michael A.
openaire +5 more sources
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]
, 2015 Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Agnarsson +78 more
core +2 more sources
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Presence and persistence of Ebola or Marburg virus in patients and survivors: A rapid systematic review [PDF]
, 2016 Background: The 2013-15 Ebola outbreak was unprecedented due to sustainedtransmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance ...
Brainard, Julii +4 more
core +3 more sources
Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]
, 2008 The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher +105 more
core +2 more sources
The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]
, 2016 Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S +4 more
core +2 more sources
Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis [PDF]
, 2015 Background The Ebola virus disease outbreak that started in Western Africa in 2013 was unprecedented because it spread within densely populated urban environments and affected many thousands of people.
Baron +26 more
core +1 more source
Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV) [PDF]
, 2017 The International Committee on Taxonomy of Viruses (ICTV) is charged with the task of developing, refining, and maintaining a universal virus taxonomy.
Dempsey, Donald M. +5 more
core +3 more sources
Global shifts in mammalian population trends reveal key predictors of virus spillover risk. [PDF]
, 2020 Emerging infectious diseases in humans are frequently caused by pathogens originating from animal hosts, and zoonotic disease outbreaks present a major challenge to global health.
Doyle, Megan M +6 more
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