Results 41 to 50 of about 7,695 (151)

Establishment of Fruit Bat Cells (Rousettus aegyptiacus) as a Model System for the Investigation of Filoviral Infection [PDF]

, 2010
Marburg virus and several species of Ebola virus are endemic in central Africa and cause sporadic outbreaks in this region with mortality rates of up to 90%. So far, there is no vaccination or therapy available to protect people at risk in these regions.
A Groseth, A Takada, A Timen, B Hartlieb, B Hartlieb, B Manicassamy, CH Calisher, D Nkoghe, DJ Middleton, E Muhlberger, E Muhlberger, EM Leroy, GA Martini, H Feldmann, I Jordan, Ingo Jordan, J Timmins, J Wenigenrath, JC Hierholzer, JE Strong, JF Drexler, JM Licata, Jonas Schmidt-Chanasit, JS Towner, JS Towner, K Halpin, L Kolesnikova, L Kolesnikova, Larissa Kolesnikova, LL Rodriguez, M Hopp, Olga Dolnik, R Swanepoel, R Swanepoel, S Becker, S Enterlein, S Enterlein, S Muller, S Urata, SK Lau, SP Luby, Stephan Becker, Stephan Günther, T Hoenen, TA Bessa, Thomas William Geisbert, TW Geisbert, VE Volchkov, Verena Krähling, Volker Sandig, X Pourrut, Y Becker   +51 more
core   +4 more sources

Infectious Subgenomic Amplicon Strategies for Japanese Encephalitis and West Nile Viruses

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
ABSTRACT Classical methods for constructing infectious cDNA clones of flaviviruses are often hindered by instability and toxicity. The Infectious‐Subgenomic‐Amplicons (ISA) method is an advancement which utilizes overlapping DNA fragments representing viral genomic sequence and in‐cell recombination to bypass bacterial plasmid assembly.
Prince Pal Singh, Nguyen Phuong Khanh Le, Uladzimir Karniychuk   +2 more
wiley   +1 more source

131 Replication and assembly of filoviruses

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014
The family of Filoviridae comprises Marburg and Ebola virus which both cause severe life-threatening diseases characterized by high fever, rash, thrombocytopenia and hemorrhagic diathesis. The pathogenesis of the syndrome is not completely understood; probably the dynamic replication of filoviruses in the infected host leads to an uncoordinated immune ...
Larissa Kolesnikova, Olga Dolnik, Gordian Schudt, Stephan Becker   +3 more
openaire   +3 more sources

Discovery of an Ebolavirus-Like Filovirus in Europe [PDF]

, 2011
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease ...
de la Cruz Martínez, Maria, Dopazo, Hernán, Echevarría, Juan E., González, Félix, Herrera, Jesus Enrique, Hutchison, Stephen K., Juste, Javier, Lipkin, W. Ian, Molero, Francisca, Negredo, Ana, Palacios, Gustavo, Pizarro, Manuel, Quetglas, Juan, Savji, Nazir, Tenorio, Antonio, Vázquez-Morón, Sonia   +15 more
core   +4 more sources

Exploring the druggability of the UEV domain of human TSG101 in search for broad‐spectrum antivirals

Protein Science, Volume 34, Issue 1, January 2025.
Abstract The ubiquitin E2 variant domain of TSG101 (TSG101‐UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101‐UEV/PTAP interactions has emerged as a promising strategy for the development of host‐oriented broad‐spectrum antivirals with low susceptibility to ...
Fernando Montero, Marisa Parra‐López, Alejandro Rodríguez‐Martínez, Javier Murciano‐Calles, Pedro Buzon, Ziying Han, L.‐Y. Lin, Maria C. Ramos, Javier Ruiz‐Sanz, Jose C. Martinez, Marco Radi, Christiane Moog, Sandra Diederich, Ronald N. Harty, Horacio Pérez‐Sánchez, Francisca Vicente, Francisco Castillo, Irene Luque   +17 more
wiley   +1 more source

Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Safietou Sankhe, Maryam Diarra, Mamadou Aliou Barry, Martin Faye, Cheikh Talla, Diogop Camara, Maimouna Mbanne, Pape Mbacke Sembene, Amadou Alpha Sall, Gamou Fall, Oumar Faye, Cheikh Loucoubar, Ousmane Faye, Ines Vigan-Womas, Keersten Michelle Ricks, Jessica Radzio-Basu, Moussa Moise Diagne, Leyi Wang   +17 more
wiley   +1 more source

The survival of filoviruses in liquids, on solid substrates and in a dynamic aerosol [PDF]

Journal of Applied Microbiology, 2010
Filoviruses are associated with high morbidity and lethality rates in humans, are capable of human-to-human transmission, via infected material such as blood, and are believed to have low infectious doses for humans. Filoviruses are able to infect via the respiratory route and are lethal at very low doses in experimental animal models, but there is ...
Lin Eastaugh, Sophie J. Smither, Mark S. Lever, Jackie Steward, T.J. Piercy   +4 more
openaire   +3 more sources

Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses. [PDF]

, 2017
Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune ...
Agrati, Albariño, Amman, Ana I. Kuehne, Andrew S. Herbert, Ariel Sobarzo, Baize, Bausch, Betts, Bornholdt, Bukreyev, Carragher, Centers for Disease Control and Prevention (CDC), Chattopadhyay, Chen V. Abramovitch Dahan, Chung, Chung, Flyak, Flyak, Grant-Klein, Guito, Gupta, Hangartner, Hoffmeister, Holl, Hutchinson, John M. Dye, Julius Julian Lutwama, Kiley, Ksiazek, Leslie Lobel, Maruyama, McElroy, McElroy, McElroy, Miller, Mire, Moses Egesa, Polina Habibulin, Rebekah M. James, Ruibal, Sanchez, Shedlock, Slenczka, Sobarzo, Sobarzo, Sobarzo, Sobarzo, Spencer W. Stonier, Stephen Cose, Towner, Valmas, van Paassen, Villinger, Zheng   +54 more
core   +1 more source

The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study

Ecology and Evolution, Volume 14, Issue 11, November 2024.
Through the evolutionary and bibliometric analyses, this study identified several critical immune genes and signaling pathways related to bat immunity. Currently, research on the immune system of bats primarily focuses on the themes of “efficient antiviral responses” and “inflammation suppression.” ABSTRACT Bats exhibit a greater capacity to tolerate ...
Rui Li, Wenliang Zhao, Apeng Chen, Zhiqiang Wu, Gejing De   +4 more
wiley   +1 more source

Fruit–frugivore dependencies are important in Ebolavirus outbreaks in Sub‐Saharan Africa

Ecography, Volume 2024, Issue 10, October 2024.
Ebolaviruses have the ability to infect a wide variety of species, with many African mammals potentially serving either as primary reservoirs or secondary amplifying hosts. Previous work has shown that frugivorous bats and primates are often associated with spillover and outbreaks.
Mekala Sundaram, Mireya Dorado, Benedicta Akaribo, Antoine Filion, Barbara A. Han, Nicole L. Gottdenker, John P. Schmidt, John M. Drake, Patrick R. Stephens   +8 more
wiley   +1 more source