Results 51 to 60 of about 9,748 (234)

The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The SARS-CoV-2 pandemic of 2020 has highlighted the great need for antiviral therapeutics. In this work, we identify a host factor, the SKI complex, is involved in replication of influenza and coronaviruses.
S. Weston, L. Baracco, C. Keller, K. Matthews, M. McGrath, James Logue, Janie Y. Liang, J. Dyall, M. Holbrook, L. Hensley, P. Jahrling, Wenbo Yu, Alexander D. MacKerell, M. Frieman   +13 more
semanticscholar   +1 more source

Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis [PDF]

, 2015
Background The Ebola virus disease outbreak that started in Western Africa in 2013 was unprecedented because it spread within densely populated urban environments and affected many thousands of people.
Baron, Bertherat, Blackley, Burke, Christie, De Roo, Faye, Formenty, Hall, Julii Brainard, Katherine Pond, Kelly Edmunds, Kunii, Lee Hooper, Mackay, McElroy, Moreau, Mupere, Nyenswah, Nyenswah, Nyenswah, Olabode, Paul R Hunter, Schibler, Victory, Vladyko, World Health Organization   +26 more
core   +1 more source

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity

Frontiers in Immunology, 2021
Multiple agents in the family Filoviridae (filoviruses) are associated with sporadic human outbreaks of highly lethal disease, while others, including several recently identified agents, possess strong zoonotic potential. Although viral glycoprotein (GP)-
Ariel S. Wirchnianski, Ariel S. Wirchnianski, Anna Z. Wec, Elisabeth K. Nyakatura, Andrew S. Herbert, Andrew S. Herbert, Megan M. Slough, Ana I. Kuehne, Eva Mittler, Rohit K. Jangra, Jonathan Teruya, John M. Dye, Jonathan R. Lai, Kartik Chandran   +13 more
doaj   +1 more source

Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. [PDF]

, 2020
Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus ...
Amara, Emmanuel, Amman, Brian R, Bairoh, Fatmata V, Bakarr, Ibrahim A, Bangura, Abdulai A, Bangura, Camilla, Bangura, Doris, Bangura, James, Belaganahalli, Manjunatha, Bird, Brian H, Chow, Andrew, Conteh, Immah, Coomber, Moinya, Dhanota, Jasjeet, Edwin, Lavalie, Foday, Ibrahim, Gbakima, Aiah A, Gibson, Alexandra, Goldstein, Tracey, Graziano, James, Guetiya Wadoum, Raoul Emeric, Jambai, Amara, Johnny, Jonathan, Kamanda, Emmanuel S, Kamara, Sorie M, Kanu, Marilyn, Kanu, Osman, Kargbo, Dickson, Koroma, Alusine H, Lebbie, Aiah, Lungai, Victor, Mazet, Jonna AK, Mereweather-Thompson, Vanessa, Musa, Jonathan, Nichol, Stuart T, Ontiveros, Victoria, Osborne, Augustus, Patel, Ketan, Robert, Willie, Saidu, Emmanuel, Schuh, Amy J, Sealy, Tara K, Singh, Tushar, Taboy, Celine H, Towner, Jonathan S, Tremeau-Bravard, Alexandre, Turay, Joseph, Turay, Mohamed, Wadsworth, Richard, Williams, Samuel Maxwell Tom   +49 more
core  

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. [PDF]

, 2014
Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses.
Davis, Benjamin, Freedman, Bruce D, Han, Ziying, Harty, Ronald N, Lee, Michael S, Liu, Yuliang, Lu, Jianhong, Olson, Mark A, Reitz, Allen B, Ruthel, Gordon, Schnell, Matthias J, Wrobel, Jay E   +11 more
core   +2 more sources

Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages

Viruses, 2019
Macrophages are one of the first and also a major site of filovirus replication and, in addition, are a source of multiple cytokines, presumed to play a critical role in the pathogenesis of the viral infection. Some of these cytokines are known to induce
Tzanko S. Stantchev, Autumn Zack-Taylor, Nicholas Mattson, Klaus Strebel, Christopher C. Broder, Kathleen A. Clouse   +5 more
doaj   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, Volume 39, Issue 3, Page 346-367, April 2026.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Forty-Five Years of Marburg Virus Research

Viruses, 2012
In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens.
Kristina Brauburger, Adam J. Hume, Judith Olejnik, Elke Mühlberger   +3 more
doaj   +1 more source

Cohorts of immature Pteropus bats show interannual variation in Hendra virus serology

Journal of Animal Ecology, Volume 95, Issue 3, Page 521-537, March 2026.
Pteropus bat with offspring, photo taken by Manuel Ruiz‐Aravena. Abstract Understanding the drivers of seasonal disease outbreaks remains a fundamental challenge in disease ecology. Periodic outbreaks can be driven by several seasonally varying factors, including pulses of susceptible individuals through births, changes in host behaviour and social ...
Daniel E. Crowley, Caylee A. Falvo, Chris K. Grant, Benny Borremans, Tamika J. Lunn, Manuel Ruiz‐Aravena, Evelyn Benson, Clifton D. McKee, Daniel J. Becker, Devin N. Jones, Trenton Bushmaker, Y. Tina Yu, Michelle Michie, Adrienne S. Dale, Lianying Yan, Spencer L. Sterling, Christopher C. Broder, Laura B. Goodman, Rasa Petraityte‐Burneikiene, Eric D. Laing, Ina L. Smith, Vincent J. Munster, Agnieszka Rynda‐Apple, Alison J. Peel, Raina Plowright   +24 more
wiley   +1 more source

Seroreactivity against Marburg or related filoviruses in West and Central Africa

Emerging Microbes and Infections, 2020
A serological survey of 2,430 archived serum samples collected between 1997 and 2012 was conducted to retrospectively determine the prevalence of Marburg virus in five African countries.
Imke Steffen, Kai Lu, N. Hoff, Prime M. Mulembakani, Emile Okitolonda Wemakoy, J. Muyembe‐Tamfum, Nicaise Ndembi, C. Brennan, J. Hackett, W. Switzer, S. Saragosti, G. Mbensa, S. Laperche, A. Rimoin, G. Simmons   +14 more
semanticscholar   +1 more source