Urgent pandemic messaging of WHO, World Bank, and G20 is inconsistent with their evidence base
Abstract When international agencies make claims of an “existential threat” to humanity and advocate for urgent action from countries, it should be a safe assumption that they are consistent with their own data. However, a review of the data and evidentiary citations underlying the claims of the World Health Organization (WHO), the World Bank, and the ...
David Bell+3 more
wiley +1 more source
Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]
Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline+9 more
core +1 more source
Can Marburg virus be sexually transmitted?
Abstract Background and Aim Marburg virus (MARV) is a highly virulent virus of animal origin and the cause of a lethal infection (known as Marburg virus disease [MVD]) with a case‐fatality ratio ranging from 24% to 90%. While the potential nonzoonotic routes of virus spread are plausible, the risk is not yet fully determined.
Hassan Karami+2 more
wiley +1 more source
Ecologic and Geographic Distribution of Filovirus Disease [PDF]
We used ecologic niche modeling of outbreaks and sporadic cases of filovirus-associated hemorrhagic fever (HF) to provide a large-scale perspective on the geographic and ecologic distributions of Ebola and Marburg viruses.
A. Townsend Peterson+37 more
core +4 more sources
An Update on the Use of Antibodies Against the Filoviruses [PDF]
Multiple recent, independent studies have confirmed that passively administered antibodies can provide effective postexposure therapy in nonhuman primates after exposure to an otherwise lethal dose of Ebola virus or Marburg virus. In this article, we review composition and performance of the antibody cocktails tested thus far, what is known about ...
openaire +3 more sources
Evolutionary maintenance of filovirus-like genes in bat genomes [PDF]
Background Little is known of the biological significance and evolutionary maintenance of integrated non-retroviral RNA virus genes in eukaryotic host genomes.
Ballinger, Matthew J+3 more
core +3 more sources
Interaction of filovirus proteins with RIG-I signaling pathways [PDF]
Filovirus family consist of highly pathogenic negative-strand RNA viruses that are characterized by their filamentous virion structure. The main focus in previous research has been on ebolaviruses and marburgviruses due to the large epidemics caused by ...
He, Felix
core
Ebola exposure, illness experience, and Ebola antibody prevalence in international responders to the West African Ebola epidemic 2014-2016: A cross-sectional study. [PDF]
BACKGROUND: Healthcare and other front-line workers are at particular risk of infection with Ebola virus (EBOV). Despite the large-scale deployment of international responders, few cases of Ebola virus disease have been diagnosed in this group.
Baguelin, Marc+10 more
core +4 more sources
ADVANCES IN TACKLING FILOVIRUSES
Filoviruses are virulent pathogens that cause deadly haemorrhagic fever in humans and non-human primates. There is currently no approved drug or vaccine to tackle this disease. Two vaccine platforms that use adenovirus vectors have completed phase I studies, while a recombinant vesicular stomatitis virus-based vaccine has successfully complet-ed a ...
Bogdan A. Šolaja, Života Selaković
openaire +3 more sources
Intracellular Events and Cell Fate in Filovirus Infection [PDF]
Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood
Corley, Ronald B.+3 more
core +4 more sources