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Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and
openaire   +1 more source

Fenntartható kétnyelvűség [PDF]

, 2016
Borbély, Anna
core   +1 more source

Genomic epidemiology of Colombian resistant <i>Candida auris</i> isolates. [PDF]

Antimicrob Agents Chemother
Alvarado Casas ML, Triana Díaz JA, Montilla-Escudero E, Prada Cardozo DA, Escandón Hernández P.   +4 more
europepmc   +1 more source

Expression of 1,3-β-glucan synthase subunits in <i>Candida glabrata</i> is regulated by the cell cycle and growth conditions and at both transcriptional and post-transcriptional levels. [PDF]

Antimicrob Agents Chemother
Gonzalez-Jimenez I, Keniya MV, Aptekmann AA, Quinteros C, Wilkerson A, Arastehfar A, Daneshnia F, Perlin DS, Shor E.   +8 more
europepmc   +1 more source

A quiet but growing threat: Global perspectives on antifungal resistance and future therapeutic approaches. [PDF]

Indian J Pharmacol
Gurajala S, Challapilla M.
europepmc   +1 more source

<i>Galleria mellonella</i> as a versatile model for investigating <i>Candida glabrata</i> virulence and antifungal resistance. [PDF]

J Med Microbiol
Holt CJD, Wiliams CC, Usher J.
europepmc   +1 more source

Molecular landscape of the fungal plasma membrane and implications for antifungal action. [PDF]

Nat Commun
Jiang J, Keniya MV, Puri A, Zhan X, Cheng J, Wang H, Lin G, Lee YK, Jaber N, Zhao C, Pang C, Hassoun Y, Zheng H, Shor E, Shi Z, Lee SH, Xu M, Perlin DS, Dai W.   +18 more
europepmc   +1 more source

Clinical and Molecular Epidemiological Characteristics of 26 Bloodstream Infection Cases Caused by Candida tropicalis. [PDF]

Mycopathologia
Lin W, Yang Q, Lin Z, Liu S, Zhang L, Jiang Y, Fang J, Peng Y, Guo P.   +8 more
europepmc   +1 more source

Targeting calcineurin: a synergistic strategy with caspofungin to induce farnesol-mediated quorum sensing in Nakaseomyces glabrata-an inoculum-dependent tale. [PDF]

Biochem J
Cen YK, Zhang LL, Zhang ZJ, Zhang YJ, Lu TX, Zhou WY, Xiang C, Xue YP, Zheng YG.   +8 more
europepmc   +1 more source

Phylogenomic analysis and genetic mechanisms of antifungal resistance in clinical isolates of <i>Candida glabrata</i> (<i>Nakaseomyces glabratus</i>) from across Canada, 2013-2020. [PDF]

Microbiol Spectr
De Luca DG, Alexander DC, Dingle TC, Dufresne PJ, Fuller J, German GJ, Haldane D, Hoang LM, Jiao L, Kus JV, Li L, Malejczyk K, Sheitoyan-Pesant C, Stein M, Graham M, Van Domselaar G, Bharat A.   +16 more
europepmc   +1 more source