Results 91 to 100 of about 698,242 (242)

Ex vivo brain MRI to assess conventional and FLASH brain irradiation effects

Background and purpose: The FLASH effect expands the therapeutic ratio of tumor control to normal tissue toxicity observed after delivery of ultra-high (>100 Gy/s FLASH-RT) vs. conventional dose rate radiation (CONV-RT).
Simon, Aaron, Mosso, Jessie, Petit, Benoit, Simon, A., Stark, C., Lanz, Bernard, Jansen, J., Drayson, O., Lanz, B., Limoli, Charles L., Franco-Perez, J., Vozenin, M.C., Ballesteros-Zebadua, P., Franco-Perez, Javier, Ballesteros-Zebadua, Paola, Kimbler, A., Grilj, V., Vozenin, Marie Catherine, Grilj, Veljko, Drayson, Olivia, Stark, Craig, Jansen, Jeannette, Mosso, J., Kimbler, Adam, Petit, B., Limoli, C.L., Vozenin, Marie-Catherine   +26 more
core   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Is singlet oxygen involved in FLASH-RT? [PDF]

J Appl Clin Med Phys, 2023
Alanazi A, Jay-Gerin JP, Blázquez-Castro A.   +2 more
europepmc   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation. [PDF]

Radiother Oncol, 2023
Limoli CL, Kramár EA, Almeida A, Petit B, Grilj V, Baulch JE, Ballesteros-Zebadua P, Loo BW, Wood MA, Vozenin MC.   +9 more
europepmc   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Mechanisms of the FLASH effect: current insights and advances

Frontiers in Cell and Developmental Biology
Radiotherapy is a fundamental tool in cancer treatment, utilized in over 60% of cancer patients during their treatment course. While conventional radiotherapy is effective, it has limitations, including prolonged treatment durations, which extend patient
Giulia Rosini, Esther Ciarrocchi, Esther Ciarrocchi, Esther Ciarrocchi, Beatrice D’Orsi, Beatrice D’Orsi, Beatrice D’Orsi   +6 more
doaj   +1 more source

Fred D. White, Writing Flash: How to Craft and Publish Flash Fiction for a Booming Market [review] [PDF]

Review of Fred D. White's Writing Flash: How to Craft & Publish Flash Fiction for a Booming Market (Fresno: Quill Driver, 2018 ...
Chantler, Ashley
core  

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Reversible, Chemically Gated FRET via Ligand‐Activated Acceptors

Advanced Science, EarlyView.
Fluorogen binding turns the compact FAST tag into a tunable FRET acceptor, with ligand chemistry programming spectral overlap and excited‐state lifetimes. Fluorescence‐lifetime imaging reads out energy transfer through the shortened donor lifetime, while simply adding or washing out the dye switches FRET on and off, reversibly mapping the supramodular ...
Nivedita Singh, Smruti Ranjan Nayak, Sanjay Kumar Mohanty, Aishwarya Hanumantharaju, Amala Shaju, Mini Jose, Aravind Penmatsa, Deepak Nair   +7 more
wiley   +1 more source