Results 101 to 110 of about 698,242 (242)

Coordinated Electronic‐Transport Regulation and Multiscale Phonon Scattering in Sb–La Co‐Doped GeTe

Advanced Science, EarlyView.
Synergistic Sb–La co‐doping simultaneously regulates hole concentration and creates strain‐field fluctuations and multiscale structural disorder in GeTe. Electrical transport is preserved, while electronic and lattice thermal conductivities are strongly suppressed.
Ting Lu, Huangshui Ma, Mingquan Li, Min Hong   +3 more
wiley   +1 more source

Dose rate and dose robustness for proton transmission FLASH-RT treatment in lung cancer. [PDF]

Front Oncol, 2022
Wei S, Lin H, Huang S, Shi C, Xiong W, Zhai H, Hu L, Yu G, Press RH, Hasan S, Chhabra AM, Choi JI, Simone CB, Kang M.   +13 more
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Toward online dose reconstruction in phantom using deep learning-based X-ray-induced acoustic imaging for X-ray FLASH radiotherapy

Nuclear Engineering and Technology
FLASH radiotherapy (FLASH-RT) is an emerging radiation therapy technique that delivers ultra-high radiation doses within an extremely short time frame, ensuring effective tumor control while significantly reducing damage to normal tissues.
Xulin Hu, Junling Wang, Dai Wu, Liuyuan Zhou, Yi Zhang, Jianwen Huo   +5 more
doaj   +1 more source

Individual pulse monitoring and dose control system for pre-clinical implementation of FLASH-RT. [PDF]

Phys Med Biol, 2022
Ashraf MR, Rahman M, Cao X, Duval K, Williams BB, Jack Hoopes P, Gladstone DJ, Pogue BW, Zhang R, Bruza P.   +9 more
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Factors Influencing the Biological Effects of FLASH Irradiation

Antioxidants
Among the methods for increasing the specificity of tumor radiotherapy, FLASH radiotherapy (FLASH-RT) stands out, having recently entered clinical trials.
Sergey Igorevich Glukhov, Elena Ananievna Kuznetsova, Sergey Vsevolodovich Akulinichev   +2 more
doaj   +1 more source

The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT. [PDF]

Int J Radiat Biol, 2022
Moon EJ, Petersson K, Olcina MM.
europepmc   +1 more source

Innovative Approach Reveals How Receptors Control G Protein State Equilibria

Advanced Science, EarlyView.
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean‐Philippe Pin   +12 more
wiley   +1 more source

FLASH radiotherapy effects: From physicochemical foundations to preclinical models -- a review

Journal of Radiation Research and Applied Sciences
The ultimate goal pursued in the field of oncology therapy is to maximize the control of lesions while reducing normal tissue damage. FLASH radiotherapy (FLASH-RT) is a new radiotherapy technology mainly characterized by ultra-high dose rate irradiation (
YuLong He, Ting Ren
doaj   +1 more source