Results 161 to 170 of about 698,242 (242)

Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection

iMeta, EarlyView.
This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu, Xiuying Tao, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +5 more
wiley   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source

Low‐Dose Chlorothalonil Induces Testicular Injury Through Disruption of Steroidogenic Signaling in Adult Male Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorothalonil (CHL) is a widely used organochlorine fungicide frequently detected in environmental and food matrices. Although increasing evidence indicates adverse effects in nontarget species, the mechanisms underlying CHL‐induced male reproductive toxicity remain incompletely understood.
Cristiana Livramento Oliveira Pinto, Nicoly Caixêta Gonçalves, Paula Rafaela Queiroz da Silva, Ludmila Rodrigues Pontes, Juliana Reis Machado, Virmondes Rodrigues Jr., Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo   +7 more
wiley   +1 more source

Modular Synthesis of C5 Sulfur‐Functionalized Oxazolidinones via Thiol‐Induced Cascade Reactions of Epoxy Carbamates

Journal of the Chinese Chemical Society, EarlyView.
A modular cascade reaction of epoxy carbamates with diverse thiols provides efficient access to C5 sulfide‐functionalized oxazolidinones. Intermolecular nucleophilic epoxide ring opening followed by intramolecular acyl substitution enables simultaneous sulfur installation and oxazolidinone formation.
Cheng‐Kun Lin, Yu‐Jin Huang, Meng‐Hsia Tsai, Yueh‐Ling Huang, Xsing‐Yi Lee, Hui‐Yin Hsu   +5 more
wiley   +1 more source

Mitochondrial Responses to Conventional and Ultra-high Dose Rate (FLASH) Radiation

PURPOSE: Ultra-high dose rate (\u3e40 Gy/s, FLASH) radiation therapy (RT) provides equivalent tumor control while reducing normal tissue toxicity relative to conventional dose rate (CONV) RT.
Caggiano, Emily G, Liu, Kevin, Gatica-Gutierrez, Henry, Hernandez, Alan Lopez, Waldrop, Trey   +4 more
core   +1 more source

Beyond a dual role: how Purpureocillium lilacinum reprograms citrus metabolism for integrated biocontrol and growth promotion

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Plants harbor complex microbial communities that are fundamental to their health and productivity. Among them, endophytic fungi such as Purpureocillium lilacinum establish mutualistic associations, offering dual benefits as plant growth promoters and biocontrol agents.
Sana Bouzembila, Kamel Charaabi, Haytham Hamden, Salma Fadhel, Nesrine Tanfouri, Meriem Msaad Guerfali   +5 more
wiley   +1 more source

Solvent‐Tuned DLP 3D‐Printed PNVCL Hydrogels With Enhanced Thermoresponse

Macromolecular Rapid Communications, EarlyView.
DLP 3D printing of PNVCL hydrogels remains challenging due to a trade‐off between printability and thermoresponsive performance. Here, DEG‐tuned P(NVCL‐DVA) organohydrogels were successfully 3D‐printed and subsequently solvent‐exchanged with water. The optimized hydrogels exhibited interconnected porous structures, high water uptake and rapid thermo ...
Charlotte Dai, Frédéric Demoly, Vincent Lapinte, Sébastien Blanquer   +3 more
wiley   +1 more source

Decoding the Gut‐Brain Axis: Multi‐Omics Reveals a Causal Chain Linking Human Genome, Gut Microbiota, Blood Metabolites, and Alertness in the Brain

Med Research, EarlyView.
This multi‐omics study identified genetic loci, gut microbiota, blood metabolites, and gray matter volumes of orbitofrontal cortex and cerebellum that were potentially relevant to alerting in healthy Chinese adults. Subsequent two‐step one‐sample Mendelian randomization further revealed a serial mediation pathway: Bacteroides intestinalis influences ...
Hongru Li, Chuansheng Chen, Ofir Turel, Yu Pu, Hong Chen, Tingyong Feng, Jiang Qiu, Xu Lei, Qinghua He   +8 more
wiley   +1 more source

Non‐Rigid Motion‐Compensated MR Multitasking for Free‐Breathing Low‐Dose Dynamic Contrast‐Enhanced MRI in the Abdomen

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To improve free‐breathing low‐dose quantitative dynamic contrast‐enhanced (DCE) MRI for imaging pancreatic ductal adenocarcinoma. Methods We introduced non‐rigid (NR) motion compensation (MoCo) into MR Multitasking using a novel “in‐subspace” formulation that directly applies motion fields to spatial feature maps (eigenimages ...
Lingceng Ma, Chaowei Wu, Lixia Wang, Hsu‐Lei Lee, Junzhou Chen, Zheyuan Hu, Yibin Xie, Stephen J. Pandol, Srinivas Gaddam, Debiao Li, Anthony G. Christodoulou   +10 more
wiley   +1 more source

Integration von Physik, Chemie und Biologie zur mechanistischen Aufklärung und klinischen Umsetzung der FLASH-Strahlentherapie mit ultrahoher Dosisrate

A novel radiation therapy (RT) modality, FLASH-RT, reduces normal tissue toxicity while maintaining tumor control by using ultra-high dose rates (UHDRs).
Baikalov, Alexander Robert
core