Results 91 to 100 of about 45,388 (244)
Advanced Science, Volume 12, Issue 45, December 4, 2025.This study establishes an efficient oleaginous heterotrophic microalga, Schizochytrium, through chassis optimization and metabolic engineering, significantly enhancing fatty acid titers and productivities. It also identifies a regulatory mechanism that coordinates biomass and lipid synthesis, providing a rational target for metabolic pathway rewiring ...
Fangzhong Wang +7 more
wiley +1 more source
Scientific Reports, 2019 Cytochrome P450 reductase (CPR) is the key protein that regulates the electron transfer from NADPH to various heme-containing monooxygenases. CPR has two flavin-containing domains: one with flavin adenine dinucleotide (FAD), called FAD domain, and the ...
Mikuru Iijima +4 more
doaj +1 more source
QM/MM Study of L-Lactate Oxidation by Flavocytochrome b2 [PDF]
, 2016 In this work, we have performed molecular dynamics simulations using a hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) scheme to study the mechanism of L-lactate oxidation by flavocytochrome b2 (Fcb2).
de la LANDE, Aurélien +6 more
core +3 more sources
Advanced Energy Materials, Volume 15, Issue 46, December 9, 2025.A sustainable bacteria‐based lithium‐ion battery cathode recycling method is optimized using engineering biology. The resulting biomineralized manganese carbonate species is found to be easily converted into an electrode material, via simple calcination.
Virginia Echavarri‐Bravo +4 more
wiley +1 more source
Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration : vitamin B2 (Riboflavin) in cancer therapy [PDF]
, 2017 Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors. This screening platform was specifically designed to detect compounds that selectively deplete cellular ATP levels, but have little or no toxic side ...
Brand +34 more
core +2 more sources
American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone +13 more
wiley +1 more source
Frontiers in Physiology, 2018 NADPH-cytochrome P450 reductase (CPR) plays an essential role in the cytochrome P450 enzyme system, which aids in the metabolism of endogenous and exogenous compounds including the detoxification of insecticides.
Tian-Xing Jing +11 more
doaj +1 more source
NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]
, 2014 [Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S. +45 more
core +4 more sources
Biomanufacturing Potential of Streamlined Cells
Biotechnology and Bioengineering, Volume 122, Issue 12, Page 3309-3318, December 2025.ABSTRACT A series of Escherichia coli streamlined strains was developed by removing the expression of genes encoding extracellular structures and unessential enzymes. The streamlined strains exhibited improved metabolic performance, including lower overflow metabolism and ATP maintenance coefficient, as well as a higher growth rate, compared to their ...
Alvaro R. Lara +10 more
wiley +1 more source
Mathematical model of the Lux luminescence system in the terrestrial bacterium Photorhabdus luminescens. [PDF]
, 2009 A mathematical model of the Lux luminescence system, governed by the operon luxCDABE in the terrestrial bacterium Photorhabdus luminescens, was constructed using a set of coupled ordinary differential equations.
Stekel, Dov J, Welham, Patricia A
core +1 more source