Results 101 to 110 of about 45,388 (244)

Integrated In Silico – In Vitro Study Investigating Dipeptides as Chorismate Synthase Modulators: Spotlight on Its Mechanism of Action

Global Challenges, Volume 9, Issue 12, December 2025.
This study integrates computational and experimental approaches to explore how short dipeptides modulate the activity of chorismate synthase. Unexpectedly, the GluAsp dipeptide enhanced enzyme activity by promoting a transient surface channel near the active site, possibly revealing a new structural feature relevant for microbial metabolism and ...
Lorenzo Pedroni, Katharina Fuchs, Gianni Galaverna, Peter Macheroux, Luca Dellafiora   +4 more
wiley   +1 more source

Atropisomeric Flavoenzyme Models with a Modified Pyrimidine Ring (BIOORGANIC CHEMISTRY-Bioorganic Reaction Theory) [PDF]

, 1997
Optically active 5-deazaflavin derivatives (3-aryl-10-(4-tert-butylphenyl)pyrimido[4,5-b]quinoline- 2,4(3H,10H)-dione) with an axial chirality at the pyrimidine ring have been synthesized, and the physical properties of these compounds have been ...
Kawai, Yasushi, Kunitomo, Jun, Ohno, Atsuyoshi   +2 more
core  

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR) [PDF]

, 2014
Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt
Alan Scott, Andrew D. Lawrence, Banerjee, Blanche, Cheng, Cheung, Christopher M. Johnson, Dalhus, Daragan, Debussche, Delaglio, Delaglio, Emsley, Evans, Fogh, Fonseca, Johnson, Kim, Lawrence, Leslie, Lexa, Mark J. Howard, Martin J. Warren, Mera, Michael A. Geeves, Michelle L. Rowe, Monera, Murshudov, Pace, Parsons, Piotto, Rashid, Richard W. Pickersgill, Samantha L. Taylor, Sampson, States, Stephen E. J. Rigby, Stich, Stich, Vagin, van den Heuvel, Vranken, Warren, Webb, Wishart, Wittung-Stafshede   +45 more
core   +3 more sources

The RFK catalytic cycle of the pathogen Streptococcus pneumoniae shows species-specific features in prokaryotic FMN synthesis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Emergence of multidrug-resistant bacteria forces us to explore new therapeutic strategies, and proteins involved in key metabolic pathways are promising anti-bacterial targets.
María Sebastián, Adrián Velázquez-Campoy, Milagros Medina   +2 more
doaj   +1 more source

Structural and functional investigation of flavin binding center of the NqrC subunit of sodium-translocating NADH:quinone oxidoreductase from Vibrio harveyi.

PLoS ONE, 2015
Na+-translocating NADH:quinone oxidoreductase (NQR) is a redox-driven sodium pump operating in the respiratory chain of various bacteria, including pathogenic species.
Valentin Borshchevskiy, Ekaterina Round, Yulia Bertsova, Vitaly Polovinkin, Ivan Gushchin, Andrii Ishchenko, Kirill Kovalev, Alexey Mishin, Galina Kachalova, Alexander Popov, Alexander Bogachev, Valentin Gordeliy   +11 more
doaj   +1 more source

Identification and characterization of a fluorescent flagellar protein from the brown alga Scytosiphon lomentaria (Scytosiphonales, Phaeophyceae): A flavoprotein homologous to Old Yellow Enzyme [PDF]

, 2005
The posterior flagellum of the zoospore of the brown alga Scytosiphon lomentaria exhibits bright green autofluorescence. To identify the fluorescent flagellar substance(s), we isolated flagella from zoospores and partially purified a flavoprotein by ...
FUJITA Satoshi, ISEKI Mineo, KAWAI Hiroshi, MAKINO Yumiko, MOTOMURA Taizo, MURAKAMI Akio, WATANABE Masakatsu, YOSHIKAWA Shinya, 正勝 渡辺   +8 more
core   +2 more sources

Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase

Frontiers in Pharmacology, 2017
All cytochromes P450s in the endoplasmic reticulum rely on P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause metabolic disorders of steroid hormone biosynthesis and affect certain drug metabolizing P450 activities.
Sameer S. Udhane, Sameer S. Udhane, Shaheena Parween, Shaheena Parween, Norio Kagawa, Amit V. Pandey, Amit V. Pandey   +6 more
doaj   +1 more source

Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor? [PDF]

, 2013
Oral or gastrointestinal mucositis is a frequent phenomenon in cancer patients receiving chemotherapy or radiotherapy. In addition, several clinical investigations have demonstrated in recent years that riboflavin laurate has the potential to protect the
Barrington, Blanck, Bodiga, Broeders, Caillot, Dexuan Yang, Fu, Giacomini, Hassan, Kratz, Miller, Nakano, Nilgün, Northrop-Clewes, Petteys, Plevova, Powers, Qishou Xu, Said, Serrano, Shanshan Wang, Shoujun Yuan, Sinigaglia-Coimbra, Sugano, Teng, Vasilaki, Wang, Wojcieszynska, Wu, Yinghong An, Youdim, Zielinska-Dawidziak, Zixue Xuan, Zur   +33 more
core   +1 more source

Structure, dynamics, and function of the monooxygenase P450 BM-3: insights from computer simulations studies [PDF]

, 2015
The monooxygenase P450 BM-3 is a NADPH-dependent fatty acid hydroxylase enzyme isolated from soil bacterium Bacillus megaterium. As a pivotal member of cytochrome P450 superfamily, it has been intensely studied for the comprehension of structure-dynamics-
Danilo Roccatano, MacKerell A, Munro A W, Narhi L O, Narhi L O, Roccatano D ed Zvelindovsky A V, van Gunsteren W F   +6 more
core   +1 more source

Direct Synthesis of Hydrogen Peroxide from Hydrogen and Oxygen by Using a Water-Soluble Iridium Complex and Flavin Mononucleotide

Angewandte Chemie, 2013
H2 , O2 to H2 O2 : The direct synthesis of hydrogen peroxide from hydrogen and oxygen in water has been made possible by using an iridium(III) complex, [Ir(III) (Cp*)(4-(1H-pyrazol-1-yl-κN(2) )benzoic acid-κC(3) )(H2 O)]2 SO4 , and flavin mononucleotide.
Satoshi Shibata, T. Suenobu, S. Fukuzumi
semanticscholar   +1 more source