Results 91 to 100 of about 7,338 (299)
Why Flavins Are not Competitors of Chlorophyll in the Evolution of Biological Converters of Solar Energy [PDF]
, 2012 Excited flavin molecules can photocatalyze reactions, leading to the accumulation of free energy in the products, and the data accumulated through biochemical experiments and by modeling prebiological processes suggest that flavins were available in the ...
Mikhail Kritsky +3 more
core +1 more source
Angewandte Chemie, EarlyView.Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez +5 more
wiley +2 more sources
Advanced Science, EarlyView.Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou +10 more
wiley +1 more source
Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization
Angewandte Chemie, EarlyView.The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu +6 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2009 Flavin chromophores can mediate redox reactions upon irradiation by blue light. In an attempt to increase their catalytic efficacy, flavin derivatives bearing a guanidinium ion as oxoanion binding site were prepared.
Harald Schmaderer +2 more
doaj +1 more source
Advanced Science, EarlyView.A unique mechanism of catalytic bias regulated by diaphorase‐like subunit in formate dehydrogenase from Rhodobacter aestuarii is revealed. The diaphorase‐like subunit functions act as a biological “voltage rheostat” that controls the slow release of NADH to regulate redox balance, biasing the enzyme's catalytic preference toward CO2 reduction over ...
Kuncheng Zhang +7 more
wiley +1 more source
A Molecular Mechanics Model for Flavins [PDF]
, 2019 International audienceFlavin containing molecules form a group of important cofactors that assist a wide range of enzymatic reactions. Flavins use the redox‐active isoalloxazine system, which is capable of one‐ and two‐electron transfer reactions and can
Aleksandrov, Alexey, Alexey Aleksandrov
core +1 more source
Discriminating Biomolecules with Coherent Control Strategies
CHIMIA, 2011 The activity of the GAP-Biophotonics research group at the University of Geneva in the field of coherent control for discriminating similar biomolecules, such as flavins, proteins and DNA bases, is presented and future developments are discussed.
Ariana Rondi +9 more
doaj +1 more source
Advanced Science, EarlyView.Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee +9 more
wiley +1 more source
EFFECT OF THE INCORPORATION INTO UNILAMINAR VESICLE ON THE PHOTODEGRADATION OF INDOLES SENSITIZED BY FLAVINS [PDF]
, 2013 In this work we study the incorporation into dipalmitoylphosphatidylcholine (DPPC) small unilamellar vesicle (SUV), of three indols: Trp, indol-3 acetamide and N-acetyl tryptophan ethyl ester (NATE), and of three flavins: riboflavin (RF), lumiflavin (LF),
A. M. Edwards +5 more
core +1 more source