Results 31 to 40 of about 41,055 (201)

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

BMC Infectious Diseases, 2018
Background Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. Methods Twenty-two C.
Longyang Jin, Zhuorui Cao, Qi Wang, Yichen Wang, Xiaojuan Wang, Hongbin Chen, Hui Wang   +6 more
doaj   +1 more source

SWL-1 Reverses Fluconazole Resistance in Candida albicans by Regulating the Glycolytic Pathway

Frontiers in Microbiology, 2020
Candida albicans is a ubiquitous clinical fungal pathogen. Prolonged use of the first-line antifungal agent fluconazole (FLC) has intensified fungal resistance and limited its effectiveness for the treatment of fungal infections.
Xiao-Ning Li, Xiao-Ning Li, Lu-Mei Zhang, Lu-Mei Zhang, Yuan-Yuan Wang, Yi Zhang, Yi Zhang, Ze-Hua Jin, Ze-Hua Jin, Jun Li, Jun Li, Rui-Rui Wang, Rui-Rui Wang, Wei-Lie Xiao   +13 more
doaj   +1 more source

Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study [PDF]

, 2013
Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany ...
Ballus, Jose, Bingold, Tobias Michael, Kaskel, Peter, Krobot, Karl J., Kumar, Ritesh N., Mavros, Panagiotis, Nocea, Gonzalo, Wissing, Heimo   +7 more
core   +1 more source

In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis

Brazilian Journal of Infectious Diseases, 2012
In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility ...
Liliane Alves Scheid, Débora Alves Nunes Mario, Thaís Felli Kubiça, Janio Morais Santurio, Sydney Hartz Alves   +4 more
doaj   +1 more source

Adhesive Properties and Sensitivity to Antifungal Drugs of Candida Albicans, Which Are Released From Patients of Gastroenterological Profile with Candidiasis of the Mucosa of the Upper Part of the Digestive Tract [PDF]

, 2016
Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during ...
Kushnirenko, I. (Inessa)
core   +2 more sources

Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity [PDF]

, 2014
Background: Candida albicans infections have become increasingly recognised as being biofilm related. Recent studies have shown that there is a relationship between biofilm formation and poor clinical outcomes in patients infected with biofilm ...
Borghi, Elisa, Falleni, Monica, Jones, Brian, Lappin, David F., Nile, Christopher, Perdoni, Federica, Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Smith, Karen, Tosi, Delfina, Williams, Craig   +11 more
core   +13 more sources

Whole Genome Sequencing Shows Genetic Diversity, as Well as Clonal Complex and Gene Polymorphisms Associated with Fluconazole Non-Susceptible Isolates of Candida tropicalis

Journal of Fungi, 2022
Resistance to azoles in Candida tropicalis is increasing and may be mediated by genetic characteristics. Using whole genome sequencing (WGS), we examined the genetic diversity of 82 bloodstream C.
Caitlin Keighley, Mailie Gall, Sebastiaan J. van Hal, Catriona L. Halliday, Louis Yi Ann Chai, Kean Lee Chew, Chayanika Biswas, Monica A. Slavin, Wieland Meyer, Vitali Sintchenko, Sharon C. A. Chen   +10 more
doaj   +1 more source

Emergence of fluconazole-resistant candida infections in diabetic foot ulcers: Implications for public health

Indian Journal of Community Medicine, 2019
Background: It is well documented in the literature that fungal infections are common in diabetic foot ulcers (DFUs). This has led to an overuse of antifungal agents, namely fluconazole, with a consequent risk of emergence of resistance to this drug ...
Chankramath S Arun, Priyanka Raju, Vivek Lakshmanan, Anil Kumar, Arun Bal, Harish Kumar   +5 more
doaj   +1 more source

Bloodstream yeast infections: a 15-month survey [PDF]

, 2009
A 15-month survey of 412 bloodstream yeast isolates from 54 Belgian hospitals was undertaken. Candida albicans was the most common species (47.3%) followed by C. glabrata (25.7%), C. parapsilosis (8.0%), C. tropicalis (6.8%) and Saccharomyces cerevisiae (
Detandt, M, Nolard, N, Swinne, D, Van Rooij, Pascale   +3 more
core   +1 more source

Synergistic Activity of Chloroquine with Fluconazole against Fluconazole-Resistant Isolates of Candida Species [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT The in vitro activity of chloroquine and the interactions of chloroquine combined with fluconazole against 37 Candida isolates were tested using the broth microdilution, disk diffusion, and Etest susceptibility tests.
Yali, Li, Zhe, Wan, Wei, Liu, Ruoyu, Li
openaire   +2 more sources