Results 1 to 10 of about 10,990 (185)

Low Glucose Mediated Fluconazole Tolerance in Cryptococcus neoformans [PDF]

Journal of Fungi, 2021
Chronic meningoencephalitis is caused by Cryptococcus neoformans and is treated in many parts of the world with fluconazole (FLC) monotherapy, which is associated with treatment failure and poor outcome. In the host, C.
Somanon Bhattacharya, Natalia Kronbauer Oliveira, Anne G. Savitt, Vanessa K. A. Silva, Rachel B. Krausert, Berhane Ghebrehiwet, Bettina C. Fries   +6 more
doaj   +5 more sources

Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans [PDF]

Frontiers in Microbiology, 2020
Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Eric Delarze, Ludivine Brandt, Emilie Trachsel, Marion Patxot, Claire Pralong, Fabio Maranzano, Murielle Chauvel, Mélanie Legrand, Sadri Znaidi, Marie-Elisabeth Bougnoux, Marie-Elisabeth Bougnoux, Marie-Elisabeth Bougnoux, Christophe d’Enfert, Dominique Sanglard   +13 more
doaj   +7 more sources

Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata [PDF]

Frontiers in Microbiology
IntroductionCandida glabrata is a prevalent opportunistic fungal pathogen in humans, and fluconazole (FLC) is one of the most commonly used antifungal agents. However, the molecular mechanisms underlying FLC tolerance in C.
Lijun Zheng, Yubo Dong, Jing Wang, Maoji Zhang, Yi Xu, Linfeng Ma, Liangsheng Guo   +6 more
doaj   +4 more sources

With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in Cryptococcus neoformans [PDF]

mBio
Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells ...
Kyungyoon Yoo, Somanon Bhattacharya, Natalia Kronbauer Oliveira, Nivea Pereira de Sa, Gabriel Soares Matos, Maurizio Del Poeta, Bettina C. Fries   +6 more
doaj   +4 more sources

Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in Saccharomyces cerevisiae and Candida albicans [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionAntifungal resistance and tolerance are distinct responses exhibited by fungi when exposed to drugs. While considerable research has focused on azole tolerance in the human pathogen Candida albicans, studies in other fungal species remain ...
Lijun Zheng, Yubo Dong, Jing Wang, Yonghui Jia, Weifang Wang, Yi Xu, Yi Xu, Liangsheng Guo   +7 more
doaj   +4 more sources

Comprehensive profiling of lysine lactylation in Candida albicans and exploratory analysis of fluconazole tolerance associations [PDF]

Microbiology Spectrum
Candida albicans is the primary pathogen of invasive candidiasis in most regions worldwide, but the therapy options for C. albicans infections are limited, and drug tolerance further exacerbates the treatment challenges.
Yuying Huang, Nana Song, Danrui Jing, Weida Liu, Dongmei Li, Xiaowei Zhou, Xiaofang Li   +6 more
doaj   +3 more sources

Fluconazole tolerance and virulence adaptations of Candida albicans isolated from head and neck cancer patients [PDF]

Journal of Oral Microbiology
Background Candida albicans is the predominant opportunistic pathogen causing oral candidiasis in immunocompromised head and neck cancer (HNC) patients.
Phimchat Suwannaphong, Patcharin Thammasit, Artid Amsri, Waranyu Ueangphairot, Pooriwat Muangwong, Kittikun Kittidachanan, Imjai Chitapanarux, Jiraporn Kantapan, Nathupakorn Dechsupa, Sirida Youngchim   +9 more
doaj   +4 more sources

Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance. [PDF]

PLoS ONE
Development of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species. The uniquely expanded C.
James O'Connor-Moneley, Jessica Fletcher, Cody Bean, Josie Parker, Steven L Kelly, Gary P Moran, Derek J Sullivan   +6 more
doaj   +7 more sources

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. [PDF]

PLoS Pathogens, 2010
Candida albicans, the major fungal pathogen of humans, causes life-threatening infections in immunocompromised individuals. Due to limited available therapy options, this can frequently lead to therapy failure and emergence of drug resistance. To improve
Elias Epp, Ghyslaine Vanier, Doreen Harcus, Anna Y Lee, Gregor Jansen, Michael Hallett, Don C Sheppard, David Y Thomas, Carol A Munro, Alaka Mullick, Malcolm Whiteway   +10 more
doaj   +6 more sources

Induction of Antifungal Tolerance Reveals Genetic and Phenotypic Changes in Candida glabrata [PDF]

Journal of Fungi
Candida glabrata is an opportunistic, pathogenic fungus that is increasingly isolated from hospitalized patients. The incidence of drug tolerance, heteroresistance, and resistance is on the rise due to an overuse of antifungal drugs.
Christy Chedraoui, Nour Fattouh, Setrida El Hachem, Maria Younes, Roy A. Khalaf   +4 more
doaj   +2 more sources