Results 11 to 20 of about 10,990 (185)

Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance

Microorganisms, 2023
Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few ...
Xiaoping Ma, Wanling Yang, Aining Yang, Dong Chen, Chengdong Wang, Shanshan Ling, Sanjie Cao, Zhicai Zuo, Ya Wang, Zhijun Zhong, Guangneng Peng, Ming He, Yu Gu   +12 more
doaj   +3 more sources

Parallel evolution of fluconazole resistance and tolerance in Candida glabrata

Frontiers in Cellular and Infection Microbiology
IntroductionWith the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. Candida species, particularly C. albicans and non-albicans Candida species such as C.
Lijun Zheng, Yi Xu, Chen Wang, Yubo Dong, Liangsheng Guo   +4 more
doaj   +3 more sources

Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole

Iranian Journal of Allergy, Asthma and Immunology, 2021
Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical ...
Michael Makris, Christos Fokoloros, Anna Syrmali, Zoi Tsakiraki, Vasileia Damaskou, Evangelia Papadavid   +5 more
doaj   +4 more sources

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C.
Yi Xu, Hua Quan, Hua Quan, Yan Wang, Hua Zhong, Jun Sun, Jianjiang Xu, Nuan Jia, Yuanying Jiang   +8 more
doaj   +3 more sources

Understanding fluconazole tolerance in Candida albicans: implications for effective treatment of candidiasis and combating invasive fungal infections

Journal of Global Antimicrobial Resistance, 2023
: Objectives: Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal ...
Yanru Feng, Hui Lu, Malcolm Whiteway, Yuanying Jiang   +3 more
doaj   +3 more sources

Candida bracarensis: Evaluation of virulence factors and its tolerance to Amphotericin B and Fluconazole [PDF]

Mycopathologia, 2015
Candida bracarensis is an uncommon Candida species found during an epidemiological study of candidiasis performed in Braga, Portugal. Initially, it was identified as C. glabrata, but recently detailed analyses pointed out their differences.
A Correia, André Moreira, Cláudia Botelho, CP Kumar, Célia Pais, D Abi-Said, DI Andersson, E Johnson, E Peeters, G Luo, G Ramage, G Ramage, JA Bishop, K Haynes, K Lewis, KH Neppelenbroek, LE Cowen, LJ Douglas, M DuBois, M Negri, MA Al-Fattani, MA Al-Fattani, MA Pfaller, MA Pfaller, Mariana Henriques, MF Price, Paula Sampaio, R Rüchel, S Silva, S Silva, S Silva, S Silva, SR Lockhart, Sónia Silva, TA Warren, VG Kumar, YH Samaranayake, YH Samaranayake, ZA Kanafani   +38 more
core   +5 more sources

Candida albicans  Genotyping and Relationship of Virulence Factors with Fluconazole Tolerance in Infected Pediatric Patients

Infection and Drug Resistance, 2022
Ghada El-Saeed Mashaly,1 Mayada Sabry Zeid2 1Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 2Infectious Diseases and Malnutrition, Pediatrics Department, Faculty of Medicine, Mansoura University,
Mashaly GE, Zeid MS
doaj   +1 more source

Selection of ethanol tolerant strains of Candida albicans by repeated ethanol exposure results in strains with reduced susceptibility to fluconazole.

PLoS ONE, 2023
Candida albicans is a commensal yeast that has important impacts on host metabolism and immune function, and can establish life-threatening infections in immunocompromised individuals. Previously, C.
Andrew W Day, Carol A Kumamoto
doaj   +4 more sources

Candida albicans  Genotyping and Relationship of Virulence Factors with Fluconazole Tolerance in Infected Pediatric Patients. [PDF]

Infect Drug Resist, 2022
Candida albicans of different genotypes is a common cause of fungal infection in pediatric setting. This cross sectional study was designed to investigate ABC genotypes and the relationship between virulence factors and fluconazole tolerance among C. albicans isolates from infected pediatric patients.C.
Mashaly GE, Zeid MS.
europepmc   +4 more sources

The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>. [PDF]

Antimicrob Agents Chemother
ABSTRACT The incidence of non- albicans Candida infections has witnessed a substantial rise in recent decades. Candida glabrata (Nakaseomyces glabratus ), an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-
Zhu Q, Wijnants S, Feil R, Van Genechten W, Vergauwen R, Van Goethem O, Lunn JE, Van Ende M, Van Dijck P.   +8 more
europepmc   +4 more sources