Results 21 to 30 of about 10,990 (185)
Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age. [PDF]
Sci Rep, 2019 AbstractCandida auris is an emerging multi-drug resistant yeast that causes systemic infections. Here we show that C. auris undergoes replicative aging (RA) that results from asymmetric cell division and causes phenotypic differences between mother and daughter cells similar to other pathogenic yeasts. Importantly, older C. auris cells (10 generations)
Bhattacharya S +3 more
europepmc +4 more sources
Fluconazole tolerance in clinical isolates of Cryptococcus neoformans [PDF]
Antimicrobial Agents and Chemotherapy, 1997 Eleven isolates of Cryptococcus neoformans were investigated to determine the biochemical basis of their tolerance to fluconazole. The MICs of fluconazole for three isolates with low-level resistance were 3- to 6-fold higher than those for sensitive isolates, while the MICs for four isolates with high-level resistance were 100- to 200-fold higher than ...
K, Venkateswarlu +4 more
openaire +4 more sources
Microbiology Spectrum, 2021 The high morbidity and mortality of cryptococcal meningitis is due to the limited range of therapeutic options: only three classes of antifungal drugs are available (polyenes [amphotericin B], azoles [fluconazole], and pyrimidine analogues [flucytosine]).
Feng Yang +6 more
doaj +1 more source
Tolerability of long-term fluconazole therapy [PDF]
Journal of Antimicrobial Chemotherapy, 2018 Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated in clinical trials, there are scant data regarding its tolerability with long-term therapy. Treatment guidelines for coccidioidomycosis recommend fluconazole therapy and severe or disseminated infections can require
Matthew R, Davis +3 more
openaire +2 more sources
Nitrogen concentration affects amphotericin B and fluconazole tolerance of pathogenic cryptococci [PDF]
FEMS Yeast Research, 2020 ABSTRACT Environmental stress often causes phenotypic changes among pathogenic cryptococci, such as altered antifungal susceptibility, changes in capsule and melanin formation, as well as altered levels of the membrane sterol and antifungal target, ergosterol.
Caylin Bosch +4 more
openaire +2 more sources
mBio, 2023 Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy
Hui Lu +16 more
doaj +1 more source
PLoS Pathogens, 2023 Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Ka Pui Sharon Yau +7 more
doaj +1 more source
mBio, 2023 Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Feng Yang +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Recurrent vulvovaginal candidiasis (RVVC) is one of the most prevalent fungal infections in humans, especially in developing countries; however, it is underestimated and regarded as an easy-to-treat condition.
Amir Arastehfar +18 more
doaj +1 more source
Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains [PDF]
, 2011 In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation.
Vitali, Alberto +6 more
core +5 more sources