Systematic truncations of chromosome 4 and their responses to antifungals in Candida albicans
Journal of Genetic Engineering and Biotechnology, 2021 Background Candida albicans is an opportunistic human fungal pathogen responsible for superficial and systemic life-threatening infections. Treating these infections is challenging as many clinical isolates show increased drug resistance to antifungals ...
Wasim Uddin +3 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
CAQ Corner: Immune‐mediated complications
, 2022 Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley +1 more source
Tolerance to fluconazole in Candida albicans is regulated by temperature and aneuploidy
Access Microbiology, 2021 Candida albicans is a prevalent human fungal pathogen. Azoles are the most widely used antifungal drugs. Drug tolerance in bacteria is well defined and thoroughly studied, but in fungi, the definition of drug tolerance and the mechanism that drive it are not well understood. Here, we found that a large proportion of clinical isolates
FENG YANG, YUANYING JIANG, JUDITH BERMAN
openaire +1 more source
Additivity interactions between fluconazole and citrus essential oils to Aspergillus fumigatus
Journal of Pre-Clinical and Clinical Research, 2021 Introduction Aspergillus fumigatus is the most common pathogen causing allergic bronchopulmonary mycosis. The pathogenic capacity of Aspergillus fumigatus is related to its thermal tolerance and the small size of the ...
Paula Wróblewska-Łuczka +1 more
doaj +1 more source
Antifungal Susceptibility Testing of Five Antifungal Agents against Clinically Isolated Dermatophytes Species from a Tertiary Care Hospital in Northern India [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Dermatophytosis form approximately 15-75% of all the mycological infections. Dermatophytes are closely related keratinolytic fungi with ability to degrade keratin and invade the skin, hair and nails causing dermatophytosis.
Sachin Sharma +4 more
doaj +1 more source
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. [PDF]
, 2018 BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently
Berman, J +13 more
core +6 more sources
Candida auris: a decade of understanding of an enigmatic pathogenic yeast [PDF]
, 2020 Candida auris is an enigmatic yeast that continues to stimulate interest within the mycology community due its rapid and simultaneous emergence of distinct clades.
Brown, Jason +4 more
core +2 more sources
Adherence of Candida albicans to Silicone Induces Immediate Enhanced Tolerance to Fluconazole [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACT Wild-type and efflux pump-deficient cells of Candida albicans adhering to silicone were compared with planktonic cells by flow cytometry for their relative resistance to fluconazole (FCZ). Flow cytometry data on cells carrying a fusion of green fluorescent protein to efflux pump promoters ...
Carolina, Mateus +2 more
openaire +2 more sources
A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. [PDF]
, 2019 Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress.
Brimacombe, Cedric A +8 more
core +3 more sources