Results 61 to 70 of about 10,990 (185)

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo

mBio, 2022
Antifungal drug resistance and tolerance pose a serious threat to global public health. In the human fungal pathogen, Candida auris, resistance to triazole, polyene, and echinocandin antifungals is rising, resulting in multidrug resistant isolates. Here,
Laura S. Burrack, Robert T. Todd, Natthapon Soisangwan, Nathan P. Wiederhold, Anna Selmecki   +4 more
doaj   +1 more source

Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis. [PDF]

, 2014
Calcineurin signaling plays diverse roles in fungi in regulating stress responses, morphogenesis and pathogenesis. Although calcineurin signaling is conserved among fungi, recent studies indicate important divergences in calcineurin-dependent cellular ...
Juvvadi, P.R., Lamoth, F., Steinbach, W.J.   +2 more
core   +1 more source

Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]

Current Medical Mycology
Background and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege, Şükrü Öksüz, Emel Akbaş, Emel Çalişkan, Mehmet Sungur   +4 more
doaj   +1 more source

Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality. [PDF]

, 2020
Metabolic adaptation is linked to the ability of the opportunistic pathogen Candida albicans to colonize and cause infection in diverse host tissues. One way that C.
Filler, Scott G, Huang, Manning Y, Lagree, Katherine, May, Gemma, McManus, C Joel, Mitchell, Aaron P, Solis, Norma V, Woolford, Carol A   +7 more
core   +3 more sources

Enhanced Tolerance to Antifungals as a General Feature of Rho⁻ Mutants in Yeast Species: Implications to Positive Selection of Respiratory Deficiency

Microorganisms
Although the mitochondrial genome is an attribute of all eukaryotes, some yeast species (called petite-positive) can replicate without mitochondrial DNA (mtDNA).
Zachary Johnson, Farhan Nadim, Mikhajlo K. Zubko   +2 more
doaj   +1 more source

Study of tolerance ability in phosphate solubilising microorganisms isolated from tea plantations soil of lower Darjeeling hills

Bulletin of the National Research Centre, 2021
Background Tea is an important plantation crop in India and world. Introduction of fertilisers and pesticides for better production polluted tea garden soils.
Sumedha Saha, Sukanya Acharyya, Sahadeb Sarkar, Malay Bhattacharya   +3 more
doaj   +1 more source

Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Antioxidants
Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it.
Wanqian Li, Yanru Feng, Zhe Feng, Li Wang, Malcolm Whiteway, Hui Lu, Yuanying Jiang   +6 more
doaj   +1 more source

Identification and Elimination of Antifungal Tolerance in Candida auris

Biomedicines, 2023
Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Samira Rasouli Koohi, Shamanth A. Shankarnarayan, Clare Maristela Galon, Daniel A. Charlebois   +3 more
doaj   +1 more source

Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability

PLANTS, PEOPLE, PLANET, EarlyView.
Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant, Katie J. Field, J. Brett Sallach, Sara Moeskjær, Alex Williams, Laura J. Carter   +5 more
wiley   +1 more source

Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

eLife, 2023
Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux, Samira Massahi, Van Bettauer, Austin Mottola, Anna Dukovny, Sanny Singh Khurdia, Anna Carolina Borges Pereira Costa, Raha Parvizi Omran, Shawn Simpson, Jinglin Lucy Xie, Malcolm Whiteway, Judith Berman, Michael T Hallett   +12 more
doaj   +1 more source