Results 81 to 90 of about 10,990 (185)

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

Transcriptome assembly and profiling of Candida auris reveals novel insights into biofilm-mediated resistance [PDF]

, 2018
Candida auris has emerged as a significant global nosocomial pathogen. This is primarily due to its antifungal resistance profile but also its capacity to form adherent biofilm communities on a range of clinically important substrates.
Ben-Ami, Berkow, Berkow, Bizerra, Bongomin, Borman, Borman, Calvo, Chatterjee, Chowdhary, Defosse, Denning, Dominguez, Fisher, Fonseca, Fox, Fu, Grahl, Haas, Hager, Hashemi, Hunter, Jeffery-Smith, Kean, Kean, Kean, Kean, Kempf, Kordalewska, Kordalewska, Larkin, Liu, Liu, Lockhart, Lohse, Martínez, Mukherjee, Naglik, Naglik, Nailis, Nobile, Perfect, Pierce, Rajendran, Rajendran, Rajendran, Ramage, Ramage, Ramage, Rodrigues, Ruiz-Gaitán, Schelenz, Sherry, Sherry, Silva, Soldini, Taff, Taff, Tumbarello, Tunney, Winter, Zarnowski, Zhao, Zhao   +63 more
core   +4 more sources

The effectiveness of voriconazole in therapy of Candida glabratas biofilms oral infections and its influence on the matrix composition and gene expression [PDF]

, 2017
Candida glabrata is one of most prevalente yeast in fungal infections, especially in immunocompromised patients. Its azole resistance results in a low therapeutic response, particularly when associated with biofilms.
Azeredo, Joana, Gonçalves, Bruna, Henriques, Mariana, Rodrigues, Célia F., Rodrigues, M. Elisa, Silva, Sónia Carina   +5 more
core   +1 more source

Polygonum cognatum Extract: Multitarget Anti‐inflammatory, Antidiabetic, and Epigenetic Modulation Properties

ChemistryOpen, Volume 15, Issue 2, February 2026.
Polygonum cognatum extracts exhibit strong antioxidant, anti‐inflammatory, antidiabetic, and antimicrobial activities. This study demonstrates, for the first time, histone deacetylase inhibitory activity, revealing epigenetic modulation potential.
Serhat Karaman, Yakup Budak, Elif Aktürk Bozdemir   +2 more
wiley   +1 more source

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China

Brazilian Journal of Infectious Diseases
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp.
Meng Li, Yong Liao, Min Chen, Weihua Pan, Lixing Weng   +4 more
doaj   +1 more source

Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]

, 2009
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho, Hamed I. Ali, Hukihisa Fujita, Morio Yamada   +3 more
core   +1 more source

Cost‐Effectiveness of Once Weekly Rezafungin for the Treatment of Invasive Candidiasis in the United Kingdom

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Invasive candidiasis (IC), life‐threatening fungal infections with high economic burden, are often treated first‐line with daily intravenous echinocandins. A new once weekly echinocandin, rezafungin, demonstrated statistically non‐inferior efficacy and numerically shorter intensive care unit (ICU) stay compared to caspofungin in ...
Noemi Muszbek, Alisha Angdembe, Carolina Garcia‐Vidal, Inga Bielicka, Keith R. Abrams, Keith Tolley, Markus Ruhnke, Maximilian Lebmeier, Neil Hawkins, Nick Manamley, Sara Dickerson   +10 more
wiley   +1 more source

Serious Bacterial Infections Acquired During Treatment of Patients Given a Diagnosis of Chronic Lyme Disease - United States. [PDF]

, 2017
The term "chronic Lyme disease" is used by some health care providers as a diagnosis for various constitutional, musculoskeletal, and neuropsychiatric symptoms (1,2).
Blackburn, Brian G, Golden, Marjorie, Green, Gary M, Greenhow, Tara, Hosain, Syed, Lomen-Hoerth, Catherine, Marzec, Natalie S, Mead, Paul S, Nelson, Christina, Waldron, Paul Ravi   +9 more
core   +1 more source

Combining the Salt‐Tolerant Plants Limonium algarvense Erben and Polygonum maritimum L. Promotes Synergistic Bioactivities for Enhanced Cosmetic Applications

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The demand for natural and sustainable ingredients in dermo‐cosmetic formulations has promoted the use of coastal salt‐tolerant plants as novel bioresources. This study evaluated aqueous extracts of Limonium algarvense and Polygonum maritimum, two salt‐tolerant coastal plants and their mixtures (3:1, 1:1, 1:3, w/w) for antioxidant, metal ...
Héctor D. Romero‐Cantú, Riccardo Trentin, Eliana Fernandes, İnci Kurt‐Celep, Gökhan Zengin, Paola Angelini, Giancarlo Angeles Flores, Luísa Custódio, Maria João Rodrigues   +8 more
wiley   +1 more source

Pharmacokinetic and Maximum Tolerated Dose Study of Micafungin in Combination with Fluconazole versus Fluconazole Alone for Prophylaxis of Fungal Infections in Adult Patients Undergoing a Bone Marrow or Peripheral Stem Cell Transplant [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACT In this dose escalation study, 74 adult cancer patients undergoing bone marrow or peripheral blood stem cell transplantation received fluconazole (400 mg/day) and either normal saline (control) (12 subjects) or micafungin (12.5 to 200 mg/day) (62 subjects) for up to 4 weeks.
Hiemenz, J., Cagnoni, P., Simpson, D., Devine, S., Chao, N., Keirns, J., Lau, W., Facklam, D., Buell, D.   +8 more
openaire   +3 more sources