The effect of midazolam and its reversal flumazenil on sedative and cardiopulmonary variables in sheep [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 The aim of this study was to investigate the effects of flumazenil antagonism after midazolam administration on sedative and cardiopulmonary variables in ewes. Six Awassi ewes were studied at least 14 days apart.
Ünal YAVUZ, Kerem YENER, Adem ŞAHAN
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Identification of Additional Cases of Severe Neonatal GABA-Transaminase Deficiency. [PDF]
JIMD RepABSTRACT GABA‐transaminase (GABA‐T) deficiency is a rare disorder of GABA metabolism characterized by neonatal encephalopathy, epilepsy, hypotonia and intellectual disability. It is caused by biallelic pathogenic variants in the ABAT gene. We report a case of a newborn female born to a G10P5 mother, with abnormal fetal movements and polyhydramnios in ...
Alammary D +8 more
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The use of flumazenil for benzodiazepine associated respiratory depression in postanesthesia recovery: risks and outcomes [PDF]
Revista Brasileira de Anestesiologia, 2018 Background and objectives The primary aim was to determine risk factors for flumazenil administration during postanesthesia recovery. A secondary aim was to describe outcomes among patients who received flumazenil.
Troy G. Seelhammer +7 more
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Safety and Efficacy of Remimazolam for General Anesthesia in Elderly Patients Undergoing Transurethral Surgery. [PDF]
Health Sci RepABSTRACT Background and Aims Remimazolam, a novel benzodiazepine, acts on the GABA receptor and is widely used for procedural sedation. To date, there are relatively few articles comparing remimazolam to propofol for general anesthesia in elderly urology patients.
Cheng Z, Li J, Zhang Y, Dai G.
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Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundBenzodiazepines have a hypnotic/sedative effect through the inhibitory action of γ-aminobutyric acid type A receptor. Flumazenil antagonizes these effects via competitive inhibition, so it has been used to reverse the effect of benzodiazepines.
Yi Jeong Kim +5 more
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Pharmaceuticals, 2023 Studies of the neurobiological causes of anxiety disorders have suggested that the γ-aminobutyric acid (GABA) system increases synaptic concentrations and enhances the affinity of GABAA (type A) receptors for benzodiazepine ligands.
Wei-Hsi Chen +8 more
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Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose [PDF]
Vojnosanitetski Pregled, 2016 Backgound/Aim. Flumazenil is benzodiazepine receptor antagonist. It has been studied for a various indications, including reversal of sedation after surgery or diagnostic procedures, awakening of comatose patients in benzodiazepine overdose, or ...
Đorđević Snežana +4 more
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A NEW APPROACH IN TREATMENT ACUTE IVERMECTIN TOXICITY IN MALE BALB-C MICE
The Iraqi Journal of Agricultural science, 2021 This study was conducted to investigate the potential therapeutic of flumazenil and neostigmine in single and combination in Balb-C mice subjected to ivermectin acute oral toxicity.
F. M. K . Al-Rekabi +2 more
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Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABAA Receptors
Brain Sciences, 2020 Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian +4 more
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