Results 41 to 50 of about 18,308 (279)

Heterogeneity and Recombination of Foot-and-Mouth Disease Virus during Multi-Strain Coinfection of Cattle

mSphere, 2023
Superinfection of cattle persistently infected with foot-and-mouth disease virus (FMDV), with a heterologous FMDV strain has been shown to generate novel recombinant viruses.
Carolina Stenfeldt, Ian Fish, Haillie C. Meek, Jonathan Arzt   +3 more
doaj   +1 more source

Evaluation of two lyophilized molecular assays to rapidly detect foot-and-mouth disease virus directly from clinical samples in field settings [PDF]

, 2017
Accurate, timely diagnosis is essential for the control, monitoring and eradication of foot‐and‐mouth disease (FMD). Clinical samples from suspect cases are normally tested at reference laboratories.
Armson, B., Chepkwony, E., Cleaveland, S., Fowler, V.L., Howson, E.L.A., Kandusi, S., Kasanga, C.J., King, D.P., Lembo, T., Madi, M., Martin, P., Mioulet, V., Sallu, R., Siddle, A., Wood, J.   +14 more
core   +1 more source

KIF5B-mediated internalization of FMDV promotes virus infection

Virologica Sinica
Foot-and-mouth disease (FMD) is a highly contagious and economically important disease, which is caused by the FMD virus (FMDV). Although the cell receptor for FMDV has been identified, the specific mechanism of FMDV internalization after infection remains unknown.
Wei Zhang, Fan Yang, Yang Yang, Weijun Cao, Wenhua Shao, Jiali Wang, Mengyao Huang, Zhitong Chen, Xiaoyi Zhao, Weiwei Li, Zixiang Zhu, Haixue Zheng   +11 more
openalex   +3 more sources

Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication.

PLoS Pathogens, 2023
Foot-and-mouth disease, a class of animal diseases, is caused by foot-and-mouth disease virus (FMDV). The metabolic changes during FMDV infection remain unclear. Here, PK-15 cells, serum, and tonsils infected with FMDV were analyzed by metabolomics.
Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Weijun Cao, Zhaoning Xue, Xiangtao Liu, Haixue Zheng   +7 more
doaj   +1 more source

Investigating intra-host and intra-herd sequence diversity of foot-and-mouth disease virus [PDF]

, 2016
Due to the poor-fidelity of the enzymes involved in RNA genome replication, foot-and-mouth disease (FMD) virus samples comprise of unique polymorphic populations.
Freimanis, Graham L., Haydon, Daniel T., King, David J., King, Donald P., Orton, Richard, Waters, Ryan A.   +5 more
core   +1 more source

Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1).

PLoS Pathogens, 2022
Previous studies have shown after the resolution of acute infection and viraemia, foot-and-mouth disease virus (FMDV) capsid proteins and/or genome are localised in the light zone of germinal centres of lymphoid tissue in cattle and African buffalo.
Lucy Gordon, Neil Mabbott, Joanna Wells, Liudmila Kulik, Nick Juleff, Bryan Charleston, Eva Perez-Martin   +6 more
doaj   +1 more source

Direct detection and characterization of foot-and-mouth disease virus in East Africa using a field-ready real-time PCR platform [PDF]

, 2017
Effective control and monitoring of foot-and-mouth disease (FMD) relies upon rapid and accurate disease confirmation. Currently, clinical samples are usually tested in reference laboratories using standardized assays recommended by The World Organisation
Armson, B., Chepkwony, E., Cleaveland, S., Fowler, V. L., Gizaw, D., Howson, E.L.A., Kandusi, S., Kasanga, C. J., King, D. P., Lembo, T., Lyons, N. A., Mioulet, V., Ndusilo, N., Nelson, W. M., Rauh, R., Wood, B. A., Yamazaki, W.   +16 more
core   +1 more source

Antiviral Activity Of Adamantane-Pyrazole Derivatives Against Foot And Mouth Disease Virus Infection In Vivo And In Vitro With Molecular Docking Study

Journal of Applied Veterinary Sciences, 2020
Foot-and-mouth disease (FMD) vaccine does not afford early effective protection until adaptive immune protection caused by the vaccination occurs. Therefore, an alternative prophylactic application of antiviral agents for inhibition of the FMD virus is ...
Mohammed M. S. Wassel, Wael M. Gamal El-Din , Ahmed Ragab, Gameel A. M. Elhag Ali, Yousry A. Ammar   +4 more
doaj   +1 more source

Crystal structure of the 3C protease from South African Territories type 2 foot-and-mouth disease virus [PDF]

, 2016
The replication of foot-and-mouth disease virus (FMDV) is dependent on the virus-encoded 3C protease (3Cpro). As in other picornaviruses, 3Cpro performs most of the proteolytic processing of the polyprotein expressed from the single open reading frame in
Curry, S, Leen, EN, Maree, FF, Yang, J
core   +4 more sources

Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus [PDF]

, 2010
Identifying when past exposure to an infectious disease will protect against newly emerging strains is central to understanding the spread and the severity of epidemics, but the prediction of viral cross-protection remains an important unsolved problem ...
A Bastos, A Bastos, A Samuel, A Thomas, A Thomas, AD Bastos, ADS Bastos, AFY Poon, AJ Drummond, B Baxt, B Shapiro, Belinda Blignaut, C Bolwell, D Paton, Daniel T. Haydon, DJ Smith, E Beck, Elizabeth E. Fry, Elizabeth Rieder, F Yates, Francois F. Maree, Hester G. O'Neill, HG van Rensburg, J Crowther, J Crowther, J Felsenstein, J Holland, J Kitson, Jacques Theron, Jan J. Esterhuysen, JC Saiz, Louise Matthews, M Lee, M Rweyemamu, M Rweyemamu, M Rweyemamu, M Suchard, M-S Lee, Mark M. Tanaka, MG Mateu, N Knowles, N Mattion, N Mattion, P Barnett, P Barnett, Pamela Opperman, R Boom, R Garten, RA Fisher, Richard Reeve, S Holm, S Lea, S Parida, Tjaart A. P. de Beer, W Vosloo, W Vosloo, W Vosloo, Wilna Vosloo, Y-C Liao   +58 more
core   +12 more sources