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Signaling through focal adhesion kinase [PDF]
Progress in Biophysics and Molecular Biology, 1999 Integrin receptor binding to extracellular matrix proteins generates intracellular signals via enhanced tyrosine phosphorylation events that are important for cell growth, survival, and migration.
Christof R. Hauck +2 more
core +5 more sources
Haematologica, 2018 Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase
Martina Rudelius +7 more
doaj +2 more sources
Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling [PDF]
Cell Communication and SignalingFocal Adhesion Kinase (FAK) is a key signaling molecule in focal adhesions (FAs) orchestrating the formation, maturation and turnover of the FA complex.
Karen Diaz-Palacios +6 more
doaj +3 more sources
Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling [PDF]
iScienceSummary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in
Laura Schwartz +10 more
doaj +2 more sources
Biology Open, 2016 Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed.
Ana L. Roa-Espitia +7 more
doaj +2 more sources
Focal Adhesion-Independent Cell Migration. [PDF]
Annual Review of Cell and Developmental Biology, 2016 Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migration.
E. Paluch, Irene M. Aspalter, M. Sixt
semanticscholar +5 more sources
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
Nature, 2010 Mechanical forces are central to developmental, physiological and pathological processes. However, limited understanding of force transmission within sub-cellular structures is a major obstacle to unravelling molecular mechanisms.
Carsten Grashoff +2 more
exaly +2 more sources
Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets [PDF]
Biomarker ResearchThe tumour microenvironment is the “hotbed” of tumour cells, providing abundant extracellular support for growth and metastasis. However, the tumour microenvironment is not static and is constantly remodelled by a variety of cellular components ...
Zonghao Liu +6 more
doaj +2 more sources
Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration [PDF]
Scientific Reports, 2015 Directed cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation.
Jui-Chung Wu +6 more
semanticscholar +3 more sources
Journal of Experimental & Clinical Cancer Research, 2018 Background Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology.
Jie Shen +9 more
doaj +2 more sources