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Mechanism of Focal Adhesion Kinase Mechanosensing.
PLoS Computational Biology, 2015 Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile
Jing Zhou +5 more
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FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]
, 2017 Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria +3 more
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ADAMTS9-regulated pericellular matrix dynamics governs focal adhesion-dependent smooth muscle differentiation [PDF]
, 2018 Focal adhesions anchor cells to extracellular matrix (ECM) and direct assembly of a pre-stressed actin cytoskeleton. They act as a cellular sensor and regulator, linking ECM to the nucleus.
Apte, S.S. +8 more
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Distribution of the cell substratum attachment (CSAT) antigen on myogenic and fibroblastic cells in culture. [PDF]
, 1985 Previous studies (Neff et al., 1982, J. Cell. Biol. 95:654-666; Decker et al., 1984. J. Cell. Biol. 99:1388-1404) have described a monoclonal antibody (CSAT Mab) directed against a complex of three integral membrane glycoproteins of 120,000-160,000 mol ...
Bradley, D +4 more
core +1 more source
Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]
, 2017 The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C +3 more
core +1 more source
Cells, 2020 Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca2+ signaling.
Jimena Canales +5 more
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, 2007 Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton.
Achim Besser +14 more
core +1 more source
Cell migration on material-driven fibronectin microenvironments [PDF]
, 2017 Cell migration is a fundamental process involved in a wide range of biological phenomena. However, how the underlying mechanisms that control migration are orchestrated is not fully understood.
Cantini, M. +4 more
core +1 more source
Focal adhesion kinase and cancer.
Histology and histopathology, 2009 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of integrin clustering, known as focal adhesions. The FAK protein has a molecular mass of 125kDa and is encoded by the FAK gene located on human chromosome 8q24.
Golubovskaya1, Vita M. +2 more
openaire +3 more sources
Nanoimaging of focal adhesion dynamics in 3D. [PDF]
PLoS ONE, 2014 Organization and dynamics of focal adhesion proteins have been well characterized in cells grown on two-dimensional (2D) cell culture surfaces. However, much less is known about the dynamic association of these proteins in the 3D microenvironment ...
Chi-Li Chiu +5 more
doaj +1 more source