Results 11 to 20 of about 1,381,729 (387)
Signaling through focal adhesion kinase [PDF]
Progress in Biophysics and Molecular Biology, 1999 Integrin receptor binding to extracellular matrix proteins generates intracellular signals via enhanced tyrosine phosphorylation events that are important for cell growth, survival, and migration.
Christof R. Hauck +2 more
core +5 more sources
Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling [PDF]
Cell Communication and SignalingFocal Adhesion Kinase (FAK) is a key signaling molecule in focal adhesions (FAs) orchestrating the formation, maturation and turnover of the FA complex.
Karen Diaz-Palacios +6 more
doaj +3 more sources
Haematologica, 2018 Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase
Martina Rudelius +7 more
doaj +2 more sources
Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling [PDF]
iScienceSummary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in
Laura Schwartz +10 more
doaj +2 more sources
Biology Open, 2016 Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed.
Ana L. Roa-Espitia +7 more
doaj +2 more sources
Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets [PDF]
Biomarker ResearchThe tumour microenvironment is the “hotbed” of tumour cells, providing abundant extracellular support for growth and metastasis. However, the tumour microenvironment is not static and is constantly remodelled by a variety of cellular components ...
Zonghao Liu +6 more
doaj +2 more sources
Focal Adhesion–Independent Cell Migration [PDF]
Annual Review of Cell and Developmental Biology, 2016 Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migration.
Ewa K. Paluch +2 more
openaire +5 more sources
Frictiotaxis underlies focal adhesion-independent durotaxis [PDF]
Nature CommunicationsCells move directionally along gradients of substrate stiffness — a process called durotaxis. In the situations studied so far, durotaxis relies on cell-substrate focal adhesions to sense stiffness and transmit forces that drive directed motion. However,
Adam Shellard +9 more
doaj +2 more sources
Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration [PDF]
Scientific Reports, 2015 AbstractDirected cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2 and examined whether these ...
Jui-Chung Wu +6 more
openaire +3 more sources
Transcriptional activation of MACF1 by NR2F1 drives WNT-mediated focal adhesion and metastasis in lung adenocarcinoma [PDF]
European Journal of Medical ResearchObjective To investigate the regulatory role of MACF1 and its upstream transcriptional control in focal adhesion remodeling and tumor progression in lung adenocarcinoma (LUAD).
Yi Zhou +4 more
doaj +2 more sources