Results 11 to 20 of about 1,259,124 (381)
Frictiotaxis underlies focal adhesion-independent durotaxis [PDF]
Nature CommunicationsCells move directionally along gradients of substrate stiffness — a process called durotaxis. In the situations studied so far, durotaxis relies on cell-substrate focal adhesions to sense stiffness and transmit forces that drive directed motion. However,
Adam Shellard +9 more
doaj +2 more sources
Transcriptional activation of MACF1 by NR2F1 drives WNT-mediated focal adhesion and metastasis in lung adenocarcinoma [PDF]
European Journal of Medical ResearchObjective To investigate the regulatory role of MACF1 and its upstream transcriptional control in focal adhesion remodeling and tumor progression in lung adenocarcinoma (LUAD).
Yi Zhou +4 more
doaj +2 more sources
Mechanism of Focal Adhesion Kinase Mechanosensing.
PLoS Computational Biology, 2015 Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile
Jing Zhou +5 more
doaj +2 more sources
Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation [PDF]
eLifeLiquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell
Abhishek Kumar +2 more
doaj +2 more sources
Science Advances, 2022 Mechanosensing is an integral part of many physiological processes including stem cell differentiation, fibrosis, and cancer progression. Two major mechanosensing systems—focal adhesions and mechanosensitive ion channels—can convert mechanical features ...
Mingxi Yao +8 more
semanticscholar +1 more source
The mechanism of force transmission at bacterial focal adhesion complexes
Nature, 2016 Leon Espinosa +2 more
exaly +2 more sources
PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]
PLoS ONE, 2011 Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu +5 more
doaj +1 more source
Cell Adhesion & Migration, 2021 MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at
Begoña Alday-Parejo +7 more
doaj +1 more source
Focal adhesions as mechanosensors: the two-spring model [PDF]
, 2004 Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton.
Schwarz, Ulrich S. +2 more
core +3 more sources
Frontiers in Cell and Developmental Biology, 2021 Background: Focal adhesion, as the intermediary between tumor cells and extracellular matrix communication, plays a variety of roles in tumor invasion, migration, and drug resistance.
Deli Mao +18 more
doaj +1 more source