Results 21 to 30 of about 1,381,729 (387)

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer

Journal of Experimental & Clinical Cancer Research, 2018
Background Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology.
Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong, Daxing Xie   +9 more
doaj   +2 more sources

Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation [PDF]

eLife
Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell
Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz   +2 more
doaj   +2 more sources

Roles of focal adhesion proteins in skeleton and diseases

Acta Pharmaceutica Sinica B, 2022
The skeletal system, which contains bones, joints, tendons, ligaments and other elements, plays a wide variety of roles in body shaping, support and movement, protection of internal organs, production of blood cells and regulation of calcium and ...
Sheng Chen, Tailin He, Yiming Zhong, Mingjue Chen, Q. Yao, Di Chen, Zengwu Shao, G. Xiao   +7 more
semanticscholar   +1 more source

Force- and cell state–dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry

Science Advances, 2022
Mechanosensing is an integral part of many physiological processes including stem cell differentiation, fibrosis, and cancer progression. Two major mechanosensing systems—focal adhesions and mechanosensitive ion channels—can convert mechanical features ...
Mingxi Yao, A. Tijore, D. Cheng, J. Li, Anushya Hariharan, B. Martinac, G. Tran Van Nhieu, C. Cox, M. Sheetz   +8 more
semanticscholar   +1 more source

PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]

PLoS ONE, 2011
Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu, Xiang Li, Manjula Sunkara, Heather Spearman, Andrew J Morris, Cai Huang   +5 more
doaj   +1 more source

MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis

Cell Adhesion & Migration, 2021
MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at
Begoña Alday-Parejo, Kedar Ghimire, Oriana Coquoz, Gioele W. Albisetti, Luca Tamò, Jelena Zaric, Jimmy Stalin, Curzio Rüegg   +7 more
doaj   +1 more source

Focal adhesions as mechanosensors: the two-spring model [PDF]

, 2004
Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton.
Schwarz, Ulrich S., Erdmann, Thorsten, Bischofs, Ilka B.   +2 more
core   +3 more sources

Cross-Talk of Focal Adhesion-Related Gene Defines Prognosis and the Immune Microenvironment in Gastric Cancer

Frontiers in Cell and Developmental Biology, 2021
Background: Focal adhesion, as the intermediary between tumor cells and extracellular matrix communication, plays a variety of roles in tumor invasion, migration, and drug resistance.
Deli Mao, Deli Mao, Deli Mao, Rui Xu, Rui Xu, Rui Xu, Hengxing Chen, Hengxing Chen, Xiancong Chen, Xiancong Chen, Dongsheng Li, Dongsheng Li, Shenglei Song, Shenglei Song, Yulong He, Yulong He, Zhewei Wei, Changhua Zhang, Changhua Zhang   +18 more
doaj   +1 more source

Remodeling of the focal adhesion complex by hydrogen-peroxide-induced senescence

Scientific Reports, 2023
Cellular senescence is a phenotype characterized by cessation of cell division, which can be caused by exhaustive replication or environmental stress. It is involved in age-related pathophysiological conditions and affects both the cellular cytoskeleton ...
Carolin Grandy, Fabian Port, Meytal Radzinski, Karmveer Singh, Dorothee Erz, Jonas Pfeil, Dana Reichmann, Kay-Eberhard Gottschalk   +7 more
doaj   +1 more source

Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway

Cell Adhesion & Migration, 2022
To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with ...
Su Jin Lee, Ji Eun Kim, Jae Won Jung, Yun Ju Choi, Jeong Eun Gong, Bounleuane Douangdeuane, Onevilay Souliya, Young Whan Choi, Sung Baek Seo, Dae Youn Hwang   +9 more
doaj   +1 more source