Results 21 to 30 of about 1,259,124 (381)
Remodeling of the focal adhesion complex by hydrogen-peroxide-induced senescence
Scientific Reports, 2023 Cellular senescence is a phenotype characterized by cessation of cell division, which can be caused by exhaustive replication or environmental stress. It is involved in age-related pathophysiological conditions and affects both the cellular cytoskeleton ...
Carolin Grandy +7 more
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Cell Adhesion & Migration, 2022 To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with ...
Su Jin Lee +9 more
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Targeting focal adhesion kinase in cancer cells and the tumor microenvironment
Experimental and Molecular Medicine, 2020 Focal adhesion kinase (FAK) is an integrin-associated protein tyrosine kinase that is frequently overexpressed in advanced human cancers. Recent studies have demonstrated that aside from FAK’s catalytic activity in cancer cells, its cellular localization
James M. Murphy +4 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2020 Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation.
Emelia A. Assar, David A. Tumbarello
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Focal adhesions in osteoneogenesis [PDF]
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2010 As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material ...
M J P, Biggs, M J, Dalby
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Biomechanical regulation of focal adhesion and invadopodia formation
Journal of Cell Science, 2020 Integrin adhesions are a structurally and functionally diverse family of transmembrane, multi-protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM).
Or-Yam Revach, I. Grosheva, B. Geiger
semanticscholar +1 more source
αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]
, 2013 The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Engler, Adam J. +9 more
core +6 more sources
mBio, 2021 Campylobacter jejuni is a major foodborne pathogen that exploits the focal adhesions of intestinal cells to promote invasion and cause severe gastritis.
Courtney M. Klappenbach +4 more
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Cas phosphorylation regulates focal adhesion assembly
eLife, 2023 Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar +4 more
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Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions [PDF]
Journal of Biological Chemistry, 2004 Focal adhesion kinase (FAK) activity and Ca(2+) signaling led to a turnover of focal adhesions (FAs) required for cell spreading and migration. We used yellow Cameleon-2 (Ycam), a fluorescent protein-based Ca(2+) sensor fused to FAK or to a FAK-related non-kinase domain, to measure simultaneously local Ca(2+) variations at FA sites and FA dynamics ...
Grégory, Giannone +6 more
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