Results 31 to 40 of about 1,381,729 (387)
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment
Experimental and Molecular Medicine, 2020 Focal adhesion kinase (FAK) is an integrin-associated protein tyrosine kinase that is frequently overexpressed in advanced human cancers. Recent studies have demonstrated that aside from FAK’s catalytic activity in cancer cells, its cellular localization
James M. Murphy +4 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2020 Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation.
Emelia A. Assar, David A. Tumbarello
doaj +1 more source
Focal adhesions in osteoneogenesis [PDF]
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2010 As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material ...
M J P, Biggs, M J, Dalby
openaire +2 more sources
mBio, 2021 Campylobacter jejuni is a major foodborne pathogen that exploits the focal adhesions of intestinal cells to promote invasion and cause severe gastritis.
Courtney M. Klappenbach +4 more
doaj +1 more source
Biomechanical regulation of focal adhesion and invadopodia formation
Journal of Cell Science, 2020 Integrin adhesions are a structurally and functionally diverse family of transmembrane, multi-protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM).
Or-Yam Revach, I. Grosheva, B. Geiger
semanticscholar +1 more source
αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]
, 2013 The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Engler, Adam J. +9 more
core +6 more sources
Cas phosphorylation regulates focal adhesion assembly
eLife, 2023 Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar +4 more
doaj +1 more source
Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions [PDF]
Journal of Biological Chemistry, 2004 Focal adhesion kinase (FAK) activity and Ca(2+) signaling led to a turnover of focal adhesions (FAs) required for cell spreading and migration. We used yellow Cameleon-2 (Ycam), a fluorescent protein-based Ca(2+) sensor fused to FAK or to a FAK-related non-kinase domain, to measure simultaneously local Ca(2+) variations at FA sites and FA dynamics ...
Grégory, Giannone +6 more
openaire +2 more sources
Myosin II-mediated focal adhesion maturation is tension insensitive.
PLoS ONE, 2013 Myosin II motors drive changes in focal adhesion morphology and composition in a "maturation process" that is crucial for regulating adhesion dynamics and signaling guiding cell adhesion, migration and fate.
Jonathan Stricker +3 more
doaj +1 more source
PLoS ONE, 2021 Biomaterial-driven modulation of cell adhesion and migration is a challenging aspect of tissue engineering. Here, we investigated the impact of surface-bound microgel arrays with variable geometry and adjustable cross-linking properties on cell adhesion ...
Janine Riegert +11 more
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